01.09.2006. - 17.11.2011.

PhD

Biomedicine

Faculty of Medicine, University of RIjeka

01.10.2001. - 12.07.2006.

B.Sc.

Molecular Biology

Faculty of Science, University of Zagreb

01.03.2022. -

Docent

Nastavna aktivnost: Zavod za histologiju i embriologiju; Znanstvena aktivnost: Neuroimunologija i biologija stanica imunološkog sustava; Regulacija CD4+ T staničnog odgovora u bolestima središnjeg živčanog sustava; Uloga perifernih signala u fiziologiji mozga

Medicinski fakultet, Sveučilište u RIjeci

01.04.2012. - 28.02.2022.

Postdoktorand / Voditelj znanstvenog tima

Uloga receptora NKG2D u regulaciji CD4+ limfocita T u kroničnim upalnim bolestima

German Rheumatism Research Centre, Berlin, Germany

17.11.2011. - 01.04.2012.

Postdoktorand

Imunosubverzivni mehanizmi mišjeg citomegalovirusa

Faculty of Medicine, University of Rijeka

01.09.2006. - 17.11.2011.

Doktorand / Asistent

Nastavna aktivnost na Zavodu za histologiju i embriologiju; Znanstvena aktivnost: Uloga proteina m04 mišjeg citomegalovirusa u izbjegavanju imunološkog odgovora posredovanog prirodno ubilačkim stanicama

Faculty of Medicine, University of Rijeka

2023.

2023 EFIS Eastern Star Award

2018.

Immunity Journal Outstanding Poster Award at the ICIS 2018, Boston, USA

2013.

EU FP7 Marie Curie Intraeuropean Fellowship for Career Development

2013.

Alexander von Humboldt Postdoctoral Fellowship

2012

Annual National Science Award for the best young scientist in Croatia

2011

Annual Award of the University of Rijeka for the best young scientist in biomedical and biotechnical research

2011

Annual Award of the University of Rijeka Science Foundation for the best scientist in basic biomedical research

2011

Annual Award of the Croatian Immunological Society for the best scientific publication in 2010/2011

2023.

Vaccination provides superior in vivo recall capacity of SARS-CoV-2-specific memory CD8 T cells

Inga Kavazović, Christoforos Dimitropoulos, Dora Gašparini , Mari Rončević Filipović, Igor Barković, Jan Koster, Niels A Lemmermann, Marina Babić, Đurđica Cekinović Grbeša, Felix M Wensveen

Cell Rep - 42 112395

Q1

2020.

NK cell receptor NKG2D enforces proinflammatory features and pathogenicity of Th1 and Th17 cells.

Babic M, Dimitropoulos C, Hammer Q, Stehle C, Heinrich F, Sarsenbayeva A, Eisele A, Durek P, Mashreghi MF, Lisnic B, Van Snick J, Löhning M, Fillatreau S, Withers DR, Gagliani N, Huber S, Flavell RA, Polic B, Romagnani C.

Journal of Experimental Medicine - 217

Q1

2019.

Mouse Cytomegalovirus m153 Protein Stabilizes Expression of the Inhibitory NKR-P1B Ligand Clr-b.

Aguilar OA, Sampaio IS, Rahim MMA, Samaniego JD, Tilahun ME, Krishnamoorthy M, Popović B, Babić M, Krmpotić A, Treanor B, Margulies DH, Allan DSJ, Makrigiannis AP, Jonjić S, Carlyle JR.

J Virol - 94

Q1

2019.

The complex of MCMV proteins and MHC class I evades NK cell control and drives the evolution of virus-specific activating Ly49 receptors.

Železnjak J, Lisnić VJ, Popović B, Lisnić B, Babić M, Halenius A, L'Hernault A, Roviš TL, Hengel H, Erhard F, Redwood AJ, Vidal SM, Dölken L, Krmpotić A, Jonjić S.

Journal of Experimental Medicine - 216 1809-1827

Q1

2018.

Boosting Type 2 Immunity: When OX40L Comes from ILC2s.

Babic M, Romagnani C.

Immunity - 48 1067-1069

Q1

2018.

The Role of Natural Killer Group 2, Member D in Chronic Inflammation and Autoimmunity.

Babic M, Romagnani C.

Front Immunol. - 9 1219

Q1

2018.

Peptide-specific recognition of human cytomegalovirus strains controls adaptive natural killer cells.

Hammer Q, Rückert T, Borst EM, Dunst J, Haubner A, Durek P, Heinrich F, Gasparoni G, Babic M, Tomic A, Pietra G, Nienen M, Blau IW, Hofmann J, Na IK, Prinz I, Koenecke C, Hemmati P, Babel N, Arnold R, Walter J, Thurley K, Mashreghi MF, Messerle M, Romagnani C.

Nature Immunology - 19 453-463

Q1

2016.

Inflammatory monocytes and NK cells play a crucial role in DNAM-1-dependent control of cytomegalovirus infection

Lenac Rovis T, Kucan Brlic P, Kaynan N, Juranic Lisnic V, Brizic I, Jordan S, Tomic A, Kvestak D, Babic M, Tsukerman P, Colonna M, Koszinowski U, Messerle M, Mandelboim O, Krmpotic A, Jonjic S.

Journal of Experimental Medicine - 213 1835-50

Q1

2015.

An endocytic YXXΦ (YRRF) cargo sorting motif in the cytoplasmic tail of murine cytomegalovirus AP2 'adapter adapter' protein m04/gp34 antagonizes virus evasion of natural killer cells.

Fink A, Blaum F, Babic Cac M, Ebert S, Lemmermann NA, Reddehase MJ.

Med Microbiol Immunol. - 204 383-94

Q1

2014.

Human ROR?t(+)CD34(+) Cells Are Lineage-Specified Progenitors of Group 3 ROR?t(+) Innate Lymphoid Cells.

Montaldo E, Teixeira-Alves LG, Glatzer T, Durek P, Stervbo U, Hamann W, Babic M, Paclik D, Stölzel K, Gröne J, Lozza L, Juelke K, Matzmohr N, Loiacono F, Petronelli F, Huntington ND, Moretta L, Mingari MC, Romagnani C.

Immunity - 41(6) 988-1000

Q1

2014.

NK/DC crosstalk in immunosurveillance: a broken relationship caused by WASP-deficiency.

Romagnani C, Babic M

Eur J Immunol - 44(4) 958-61

Q1

2013.

Dual Analysis of the Murine Cytomegalovirus and Host Cell Transcriptomes Reveal New Aspects of the Virus-Host Cell Interface

Juranic Lisnic, V; Babic Cac, M; Lisnic, B; Trsan, T; Mefferd, A; Mukhopadhyay, C Das; Cook, CH; Jonjic, S; Trgovcich, J;

PLOS Pathogen

2013.

Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1?

Tršan, Tihana; Busche, Andreas; Abram, Maja; Wensveen, Felix M; Lemmermann, Niels A; Arapović, Maja; Babić, Marina; Tomić, Adriana; Golemac, Mijo; Brinkmann, Melanie M;

Proceedings of the National Academy of Sciences - 110 16550-16555

2013.

ROR?t? innate lymphoid cells acquire a proinflammatory program upon engagement of the activating receptor NKp44

Glatzer, T; Killig, M; Meisig, J; Ommert, I; Luetke-Eversloh, M; Babic, M; Paclik, D; Blüthgen, N; Seidl, R; Seifarth, C;

Immunity - 38 1223-35

2013.

Comprehensive Analysis of Varicella-Zoster Virus Proteins Using a New Monoclonal Antibody Collection

Roviš, Tihana Lenac; Bailer, Susanne M; Pothineni, Venkata R; Ouwendijk, Werner JD; Šimić, Hrvoje; Babić, Marina; Miklić, Karmela; Malić, Suzana; Verweij, Marieke C; Baiker, Armin;

Journal of virology - 87 6943-6954

2013.

The human cytomegalovirus UL51 protein is essential for viral genome cleavage-packaging and interacts with the terminase subunits pUL56 and pUL89

Borst, Eva Maria; Kleine-Albers, Jennifer; Gabaev, Ildar; Babić, Marina; Wagner, Karen; Binz, Anne; Degenhardt, Inga; Kalesse, Markus; Jonjić, Stipan; Bauerfeind, Rudolf;

Journal of virology - 87 1720-1732

2012.

Degradation of cellular mir-27 by a novel, highly abundant viral transcript is important for efficient virus replication in vivo

Marcinowski, Lisa; Tanguy, Mélanie; Krmpotic, Astrid; Rädle, Bernd; Lisnić, Vanda J; Tuddenham, Lee; Chane-Woon-Ming, Béatrice; Ruzsics, Zsolt; Erhard, Florian; Benkartek, Corinna;

PLoS pathogens - 8 e1002510

2011.

Distinct MHC class I–dependent NK cell–activating receptors control cytomegalovirus infection in different mouse strains

Pyzik, Michał; Charbonneau, Benoit; Gendron-Pontbriand, Eve-Marie; Babić, Marina; Krmpotić, Astrid; Jonjić, Stipan; Vidal, Silvia M;

The Journal of experimental medicine - 208 1105-1117

2011.

All is fair in virus–host interactions: NK cells and cytomegalovirus

Babić, Marina; Krmpotić, Astrid; Jonjić, Stipan;

Trends in molecular medicine - 17 677-685

2010.

Recombinant mouse cytomegalovirus expressing a ligand for the NKG2D receptor is attenuated and has improved vaccine properties

Slavuljica, Irena; Busche, Andreas; Babić, Marina; Mitrović, Maja; Gašparović, Iva; Cekinović, Đurđica; Car, Elitza Markova; Pugel, Ester Pernjak; Ciković, Ana; Lisnić, Vanda Juranić;

The Journal of clinical investigation - 120 4532

2010.

5-HT< sub> 2A</sub> receptor gene polymorphisms in Croatian subjects with autistic disorder

Hranilovic, Dubravka; Blazevic, Sofia; Babic, Marina; Smurinic, Maja; Bujas-Petkovic, Zorana; Jernej, Branimir;

Psychiatry research - 178 556-558

2010.

Cytomegalovirus immunoevasin reveals the physiological role of “missing self” recognition in natural killer cell dependent virus control in vivo

Babić, Marina; Pyzik, Michal; Zafirova, Biljana; Mitrović, Maja; Butorac, Višnja; Lanier, Lewis L; Krmpotić, Astrid; Vidal, Silvia M; Jonjić, Stipan;

The Journal of experimental medicine - 207 2663-2673

2009.

Ly49P recognition of cytomegalovirus-infected cells expressing H2-Dk and CMV-encoded m04 correlates with the NK cell antiviral response

Kielczewska, Agnieszka; Pyzik, Michal; Sun, Tianhe; Krmpotic, Astrid; Lodoen, Melissa B; Munks, Michael W; Babic, Marina; Hill, Ann B; Koszinowski, Ulrich H; Jonjic, Stipan;

The Journal of experimental medicine - 206 515-523

2008.

Hyperserotonemia in autism: the potential role of 5HT-related gene variants

Hranilović, Dubravka; Novak, Ruđer; Babić, Marina; Novokmet, Mislav; Bujas-Petković, Zorana; Jernej, Branimir;

Collegium antropologicum - 32 75-80

2008.

Immune evasion of natural killer cells by viruses

Jonjić, Stipan; Babić, Marina; Polić, Bojan; Krmpotić, Astrid;

Current opinion in immunology - 20 30-38

18.09.2021.

NK Cell Receptors and Pathogenicity of T cells in Arthritis

Marina Babic Cac

Nürnberg, Njemačka

24.09.2021.

The proinflammatory role of NKG2D during experimental autoimmune encephalomyelitis

Marina Babic Cac

usmeno izlaganje

Godišnji skup Hrvatskog imunološkog društva Arbanija, otok Čiovo, Hrvatska

01.10.2020.

NK cell receptor NKG2D enforces pro-inflammatory features and pathogenicity of Th1 and Th17 cells.

Marina Babic Cac

usmeno izlaganje

Godišnji skup Hrvatskog imunološkog društva virtualno

27.10.2018.

NKG2D modulates the proinflammatory features of Th1 and Th17 cells and contributes to their pathogenicity in vivo

Marina Babic Cac

posterno priopćenje

Annual Meeting of International Cytokine and Interferon Society Boston, USA

19.10.2018.

NKG2D modulates the proinflammatory features of Th1 and Th17 cells and contributes to their pathogenicity in vivo

Marina Babic Cac

usmeno izlaganje

Godišnji skup Hrvatskog imunološkog društva Zadar, Hrvatska

06.09.2015.

The activating receptor NKG2D regulates IL-10 expression in Th1 cells

Marina Babic Cac

usmeno izlaganje

European Congress of Immunology Beč, Austrija

17.01.2014.

The expression of NKG2D impacts the induction of IL-10 in Th1 cells

Marina Babic Cac

usmeno izlaganje

Keystone Symposia on Emerging Cytokine Networks Vancouver, Canada

26.09.2012.

Highly abundant MCMV transcript with coding and non-coding functions is necessary for recognition of m04/MHC I complex by activating Ly49 receptors

Marina Babic Cac

usmeno izlaganje

2012 NK Cell Symposium Heidelberg, Njemačka

18.04.2011.

NK cell recognition of the ‘missing-self’ in the control of a viral pathogen in vivo

Marina Babic Cac

usmeno izlaganje

NK Cell Symposium Mainz, Njemačka

11.09.2010.

THE MOUSE CYTOMEGALOVIRUS PROTEIN PREVENTS NK CELL ACTIVATION VIA „MISSING SELF“ MECHANISM

Marina Babic

usmeno izlaganje

12th Meeting of the Society for Natural Immunity Cavtat, Hrvatska

06.2021.

2021 NK Cell Symposium, godišnji sastanak Njemačkog društva za imunologiju, radna grupa NK stanice

virtual/Berlin, Njemačka ko-organizator

2012. -

Long Night of Science

Event za popularizaciju znanosti

Berlin, Germany

2024. - 2025.

Uloga receptora NKG2D u formiranju imunosnog odgovora posredovanog intestinalnim urođenim limfoidnim stanicama

voditelj

UniRI 6.730,50

2023. - 2027.

Senzor staničnog stresa NKG2D-uloga u neuroinflamatornom poremećaju

voditelj

HrZZ 199.037,96 EUR

2022. - 2023.

NKG2D-mediated regulation of CD4+ T lymphocyte function in chronic inflammatory and autoimmune diseases

voditelj

UniRI 2400 EUR

2021. - 2022.

Danger-sensing receptor NKG2D shapes the pool of intestinal innate lymphoid cells

voditelj

DFG 20 000 EUR

2021.

Peptide-based vaccination targeting innate responses against viral infection and cancer

suradnik

BIH Spark Validation Fund 75.000 EUR

2018. - 2021.

Modulation of T helper cell functions by stress-sensing receptor NKG2D

voditelj

DFG 241.950 EUR

2018. - 2019.

Peptide-based vaccination targeting innate responses against viral infection and cancer

suradnik

BIH Spark Validation Fund 50.000 EUR

2013. - 2016.

The role of NKG2D in CD4+ T cell function and autoimmunity

voditelj

EU - FP7 168.794,40 EUR

2007. - 2011.

Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru

suradnik

MZOŠ 102.740 EUR

2007. - 2010.

Transcriptomic Approach to Viral Disease Research

suradnik

MZOŠ 106.415 EUR