06.09.2009. - 31.05.2013.

Doctor of philosophy

Doctoral program in Physiology

Wayne State Univeristy School of Medicine

30.08.2005. - 12.06.2009.

Bachelor of Science

Biochemistry

University of Detroit Mercy

08.02.2020. -

Docent

Sudjelujem u nastavi na kolegiju Neurofiziologije za studente medicine. Voditelj sam istraživačke grupe koje se bavi proučavanjem neuronskih mehanizama koji kontroliraju spinalne reflekse nakon ozljede kralježničke moždine.

Medicinski fakultet Sveučilišta u Rijeci

01.06.2013. - 10.03.2017.

Postdoktorand

Tijekom mojeg rada na Wayne State University u Detroitu vodim i nadgledam djelovanje znanstveno istraživačke grupe koja se bavi istraživanjem autonomne disrefleksije i uloge simpatičnih živaca u toj patologiji. U grupu se uklapaju studenti medicine, tehničari i nekoliko profesora suradnika. U sklopu programa, organizirala sam kolaboraciju sa Prof. Scott Smith na University of Texas at Southwestern i Prof. Cheng Ly na University of Virginia Commonwealth za osnivanje pred-kliničkog animalnog modela za kvantitativnu procjenu regionalne živčane aktivnosti u štakorima sa ozljedom kralježničke moždine. Kolaboracija je rezultirala sažetcima prezentiranim na internacionalnim konferencijama, institucijskom financijskom potporom i, za sada, jednim znanstvenim radom objavljenim u kvalitetnom magazinu. U kolaboraciji sa Prof. Christian A. Reynolds, otkrivam endogene ligande TRPV1 kanala koji utječu na osjetljivost živčanih stanica umiješanih u autonomnu disrefleksiju. Drugi znanstveni radovi su u pripremi. Drugi glavni fokus mojeg rada je kolaboracija sa kliničkim kolegama na projektu pod nazivom: “Pilot Study of Mecamylamine for Automatic Dysreflexia Prophylaxis”. Kolaboracija je rezultirala financijskom potporom i za sada, jednim znanstvenim radom. Moja uloga u projektu je u organiziranju i nadziranju osoblja  što se tiče procijene varijabilnosti srčanih otkucaja u pacijentima sa ozljedom kralježničke moždine. Cilj studije je procijeniti efikasnost lijeka, „mecamylamine“, za prevenciju autonomne disrefleksije. U te svrhe napisali smo inovativan matematički code koji će se koristiti za analizu prikupljenih kliničkih podataka. Kolaboracija je u razvoju i najmanje dva dodatna znanstvena rada su u planu/pripremi.

Wayne State University School of Medicine

13.07.2018.

Barth Syndrome Foundation for abstract entitled “Nicotinamide replacement improves mitochondrial function in preclinical models of Barth Syndrome.” at Barth Syndrome Foundation 9th International Conference, Clear Water, FA, 2018

21.05.2017.

American Thoracic Society Abstract Scholarship for abstract entitled “Chronic C2 Spinal Cord Hemisection Induces Sleep Disordered Breathing” at the 2017 American Thoracic Society Meeting, Washington DC

09.12.2015.

International Symposium for Neural Regeneration Travel Award for work entitled “Differential neural control of the efferent sympathetic nerve activity during autonomic dysreflexia in a rat model of spinal cord injury” at the 2015 International Symposium for Neural Regeneration, Pacific Grove, CA

07.12.2013.

International Symposium for Neural Regeneration Travel Award for work entitled “Theophylline or DPCPX Conjugated Nanodevices Induce Functional Recovery of the Paralyzed Hemidiaphragm Following C2 Hemisection” at the 2013 International Symposium for Neural Regeneration, Pacific Grove, CA

21.06.2012.

Wayne State University Graduate School Exhibition Poster Award for poster presentation entitled “Modulation of cardiopulmonary chemoreflex control of regional sympathetic activity by A2a adenosine receptors located in the nucleus of the solitary tract” at the 2012 Wayne State University Graduate School Exhibition, Detroit, MI

12.02.2020. -

Neurofiziologija

Medicina

Sveuciliste u Rijeci

Suradnik

22.09.2015. - 22.09.2019.

Physiology

Medicina

Wayne State University

Suradnik

15.01.2015. - 15.01.2019.

Advanced Respiratory Physiology

Medicina

Wayne State University

Suradnik

2019.

Development of a decerebrate model for investigating mechanisms mediating viscero-sympathetic reflexes in the spinalized rat

Reynolds, Christian A; O’Leary, Donal S; Ly, Cheng; Smith, Scott A; Minic, Zeljka;

American Journal of Physiology-Heart and Circulatory Physiology - 316 H1332-H1340

2018.

Response to Phillips et al.(doi: 10.1089/neu. 2017.5082): An Autonomic Neuroprosthesis: Non-Invasive Electrical Spinal Cord Stimulation Restores Autonomic Cardiovascular Function in Individuals with Spinal Cord Injury

Minic, Zeljka; Nieshoff, Edward C;

Journal of neurotrauma - 35 874-875

2018.

Response to Phillips et al.:" An Autonomic Neuroprosthesis: Non-Invasive Electrical Spinal Cord Stimulation Restores Autonomic Cardiovascular Function in Individuals with Spinal Cord Injury"

Minic, Zeljka; Nieshoff, Edward C;

JOURNAL OF NEUROTRAUMA - 35 874-875

2018.

Colocalization of A2a but not A1 adenosine receptors with GABA-ergic neurons in cardiopulmonary chemoreflex network in the caudal nucleus of the solitary tract

Minic, Zeljka; O'Leary, Donal S; Goshgarian, Harry G; Scislo, Tadeusz J;

Physiological reports - 6 e13913

2017.

Nanoconjugate-bound adenosine A1 receptor antagonist enhances recovery of breathing following acute cervical spinal cord injury

Minic, Zeljka; Wilson, Sharowyn; Liu, Fangchao; Sankari, Abdulghani; Mao, Guangzhao; Goshgarian, Harry;

Experimental neurology - 292 56-62

2016.

Transporter protein and drug-conjugated gold nanoparticles capable of bypassing the blood-brain barrier

Zhang, Yanhua; Walker, Janelle Buttry; Minic, Zeljka; Liu, Fangchao; Goshgarian, Harry; Mao, Guangzhao;

Scientific reports - 6 25794

2016.

Transporter protein-coupled DPCPX nanoconjugates induce diaphragmatic recovery after SCI by blocking adenosine A1 receptors

Minic, Zeljka; Zhang, Yanhua; Mao, Guangzhao; Goshgarian, Harry G;

Journal of Neuroscience - 36 3441-3452

2015.

NTS adenosine A2a receptors inhibit the cardiopulmonary chemoreflex control of regional sympathetic outputs via a GABAergic mechanism

Minic, Zeljka; O'Leary, Donal S; Scislo, Tadeusz J;

American Journal of Physiology-Heart and Circulatory Physiology - 309 H185-H197

2014.

Nucleus tractus solitarii A2a adenosine receptors inhibit cardiopulmonary chemoreflex control of sympathetic outputs

Minic, Zeljka; O'Leary, Donal S; Scislo, Tadeusz J;

Autonomic Neuroscience - 180 32-42

2014.

Severe hemorrhage attenuates cardiopulmonary chemoreflex control of regional sympathetic outputs via NTS adenosine receptors

Minic, Zeljka; Li, Cailian; O'Leary, Donal S; Scislo, Tadeusz J;

American Journal of Physiology-Heart and Circulatory Physiology - 307 H904-H909

2012.

Activation of NTS A1 adenosine receptors inhibits regional sympathetic responses evoked by activation of cardiopulmonary chemoreflex

Ichinose, Tomoko K; Minic, Zeljka; Li, Cailian; O'Leary, Donal S; Scislo, Tadeusz J;

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology - 303 R539-R550

11.01.2019.

Regulation of Viscerosensory-Sympathetic Reflexes following Spinal Cord Injury: The Role of Diet-Derived Lipid Mediators

Reynolds CA, Maddipati KR, Minic Z.

Michigan, USA

17.05.2017.

Chronic cervical SCI in rat model is associated with Sleep Disordered Breathing.

Minic Z, Shanidze M, Goshgarian HG, Sankari A

District of Columbia, USA

12.06.2013.

Theophylline -or DPCPX-conjugated nanodevices induce functional recovery of the paralyzed hemidiaphragm following C2 hemisection.

Minic Z, Buttry JL, Zhang Y, Mao, Goshgarian HG.

California, USA

13.07.2012.

Stimulation of NTS adenosine receptors inhibits cardiopulmonary chemoreflex control of adrenal (ASNA) lumbar (LSNA) and renal (RSNA) sympathetic nerve activity via activation of GABA-ergic neurons.

Minic Z, O'Leary DS, and Scislo TJ.

Michigan, USA

2017

A29 UPDATES IN CONTROL OF BREATHING: Chronic C2 Spinal Cord Hemisection Induces Sleep Disordered Breathing

Minic, Zeljka; Shanidze, Medea; Goshgarian, Harry; Sankari, Abdulghani;

2016

Acute Cervical Spinal Cord Injury Exhibits Sleep Disordered Breathing In A Rat Model

Minic, Zeljka; Shanidze, Madea; Wahlstrom, Daniel R; Goshgarian, Harry; Sankari, Abdulghani;

2016

C19 FROM GENES TO MOTOR NEURONS: ADVANCES IN CONTROL OF BREATHING: Acute Cervical Spinal Cord Injury Exhibits Sleep Disordered Breathing In A Rat Model

Minic, Z; Shanidze, M; Wahlstrom, DR; Goshgarian, H; Sankari, A;

2013

Severe hemorrhage attenuates cardiopulmonary chemoreflex (CCR) control of renal and adrenal sympathetic nerves via adenosine operating in the nucleus of the solitary tract (NTS)

Minic, Zeljka; Li, Cailian; O’Leary, Donal S; Scislo, Tadeusz J;

2013

Mechanisms mediating modulation of cardiopulmonary chemoreflex control of regional sympathetic activity by adenosine A1 and A2a receptors located in the NTS

Minic, Zeljka;

2012

A2a adenosine receptors modulate cardiopulmonary chemoreflex control of regional sympathetic outputs via activation of GABAergic neurons within the caudal portion of the nucleus of the solitary tract (cNTS): functional and anatomical evidence

Minic, Zeljka; Llewellyn-Smith, Ida J; O'Leary, Donal S; Scislo, Tadeusz J;

2011

Activation of NTS A2a adenosine receptors impairs cardiopulmonary chemoreflex (CCR) responses of renal (RSNA), adrenal (ASNA), and lumbar (LSNA) sympathetic nerve activity via activation of GABA-ergic neurons

Minic, Zeljka; O’Leary, Donal S; Scislo, Tadeusz J;

2010

Activation of NTS A2a Adenosine Receptors Impairs Cardiopulmonary Chemoreflex Control of Renal (RSNA), Adrenal (ASNA) and Lumbar (LSNA) Sympathetic Nerve Activity

Minic, Zeljka; O’Leary, Donal S; Scislo, Tadeusz J;

2010

Activation of NTS A (2a) Adenosine Receptors Impairs Cardiopulmonary Chemoreflex Control of Renal (RSNA), Adrenal (ASNA) and Lumbar (LSNA) Sympathetic Nerve Activity

Minic, Zeljka; O'Leary, Donal S; Scislo, Tadeusz J;

2010

Mechanisms Mediating Heart Rate (HR) Responses Evoked by Activation of NTS A1 Adenosine Receptors

McClure, Joseph Martin; Minic, Zeljka; Li, Cailian; O’Leary, Donal S; Scislo, Tadeusz J;

2020.

International Journal of Molecular Sciences IJMS-853754 Cells Cells-773827

2019.

Journal of Integrative Neurophysiology JIN201901153 AJP-Heart and Circulatory Physiology H-00525-2019R1 Journal of Neurotrauma NEU-2018-6358 Journal of Cardiovascular Pharmacology and Therapeutics JCPT-2018-Dec-0300 Experimental Physiology EP-RP-2018-087534

2018.

Experimental Physiology EP-RP-2018-087013 Experimental Physiology EP-RP-2018-086951

2017.

Experimental Physiology, EP-RP-2017-086686 Scientific reports, SREP-17-11925

2015.

Journal of Advanced Research, JARE-D-15-00014

17.09.2016. -

Clan povjerenstva za dobrobit zivotinja

WSU Institutional Animal Care and Use Committee (IACUC) member

04.12.2019. - 04.12.2020.

Mecamylamine for the prophylactic management of autonomic dysreflexia and associated vascular pathology following spinal cord injury

Voditelj

Cardiovascular Research Institute, Wayne State University $25.000,00

2019. - 31.12.2020.

Pilot Study of Mecamylamine for Autonomic Dysreflexia Prophylaxis

Suradnik

Dell Harder Foundation $50.000,00

26.03.2017. - 31.12.2019.

Development of a decerebrate model for investigating mechanisms mediating viscero-sympathetic reflexes in the spinalized rat

Voditelj

Cardiovascular Research Institute and Office of Vice Presidents for Research $4.000,00