Tihana Tršan dipl.ing.bioteh.

Medicinski fakultet Katedra za histologiju i embriologiju

prostorija : Zavod za histologiju i embriologiju
mobitel :
e-pošta : tihana.trsan@medri.uniri.hr

Obrazovanje

- diplomirani inženjer biotehnologije Studij Biotehnologije, smjer: Biokemijsko-mikrobiološki Prehrambeno-biotehnološki fakultet, Sveučilište u Zagrebu
- doktor znanosti Poslijediplomski sveučilišni (doktorski) studij: Biotehnologija i bioprocesno inženjerstvo Prehrambeno-biotehnološki fakultet, Sveučilište u Zagrebu

Radno iskustvo

- Poslijedoktorand Zavod za histologiju i embriologiju / Centar za proteomiku, Medicinski fakultet Sveučilišta u Rijeci
- Znanstveni novak - asistent Zavod za histologiju i embriologiju / Centar za proteomiku, Medicinski fakultet Sveučilišta u Rijeci
- Procesni inženjer - istraživač Pliva Hrvatska d.o.o., Istraživanje i razvoj

Nagrade i priznanja

FEMS Young Scientist Meeting Grant
Nagrada za poster prezentaciju, Hrvatsko imunološko društvo
Nagrada za poster prezentaciju, Hrvatsko imunološko društvo
Croatian Ministry of Science, Education and Sport Scholarship for talented students
EFIS short-term fellowship
IHW 2014 Scholarship / travel bursary
Nagrada za najbolju znanstvenu publikaciju u 2013, Hrvatsko imunološko društvo
Nagrada za najboljeg znanstvenog novaka / asistenta iz Biomedicinskih i biotehničkih znanosti u akademskoj godini 2013/2014, Zaklada Sveučilišta u Rijeci

Članstva

- Hrvatsko imunološko društvo

Nastavna djelatnost

Kolegiji

- Molekularna biologija
Preddiplomski stručni studij ‘’Medicinsko-laboratorijska dijagnostika''
Medicinski fakultet Rijeka
Suradnik
Norma sati:
- Molekularna biologija
Preddiplomski stručni studij ‘’Medicinsko-laboratorijska dijagnostika''''
Fakultet zdravstvenih studija, Rijeka
Suradnik
Norma sati:
- Osnove histologije
Preddiplomski stručni studij ‘’Medicinsko-laboratorijska dijagnostika''
Medicinski fakultet Rijeka
Suradnik
Norma sati:
- Osnove histologije
Preddiplomski stručni studij ‘’Medicinsko-laboratorijska dijagnostika''
Fakultet zdravstvenih studija, Rijeka
Suradnik
Norma sati:
- Anatomija i histologija
Preddiplomski stručni studij ''Fizioterapija''
Medicinski fakultet Rijeka
Suradnik
Norma sati:
- Anatomija i histologija
Preddiplomski stručni studij ''Fizioterapija''
Fakultet zdravstvenih studija, Rijeka
Suradnik
Norma sati:
- Histologija i embriologija
Integrirani preddiplomski i diplomski sveučilišni studij ''Medicina''
Medicinski fakultet Rijeka
Suradnik
Norma sati:
- Histologija i embriologija
Integrirani preddiplomski i diplomski sveučilišni studij ‘’Dentalna medicina’’
Medicinski fakultet Rijeka
Suradnik
Norma sati:
- Anatomija i histologija
Preddiplomski sveučilišni studij ''Sanitarno inženjerstvo''
Medicinski fakultet Rijeka
Suradnik
Norma sati:
- Biologija herpesvirusa
Poslijediplomski sveučilišni (doktorski) studij ‘’Biomedicina’’
Medicinski fakultet Rijeka
Suradnik
Norma sati:
- Imunost na viruse
Poslijediplomski sveučilišni (doktorski) studij ‘’Biomedicina’’
Medicinski fakultet Rijeka
Suradnik
Norma sati:
- Imunologija
Preddiplomski sveučilišni studij ‘’Biotehnologija i istraživanje lijekova’’
Odjel za biotehnologiju Sveučilišta u Rijeci
Suradnik
Norma sati:

Osobni razvoj

22.9.2016. - 23.9.2016. 8th EuroMAbNet meeting


Norma sati: workshop
- Research position within Marie Curie Research Training Network MRTN-CT-2005-019248 ''NK defense and therapy''


Norma sati: 4 mjeseca
- Research position within "Viral Strategies of Immune Evasion" (VISTRIE), Helmholtz Association: Helmholtz Virtual Institutes


Norma sati: 3 tjedna
- Laboratory Animal Science Course, FELASA cat. C equivalent


Norma sati:
- Guest researcher on the subject: ''The role of NKG2D ligand RAE-1? expressed by CMV vector in promoting of the memory CD8 T cell response''


Norma sati: 2 mjeseca
- Collaboration on the project ''Becoming entrepreneurial: Knowledge transfer from the University of Rijeka Faculty of Medicine to the biotechnology business sector''


Norma sati: 1 tjedan
- Visit in frame of the project ''Becoming entrepreneurial: Knowledge transfer from the University of Rijeka Faculty of Medicine to the biotechnology business sector''


Norma sati: 1 tjedan
- Collaboration on the project ''Methods for high-throughput glycoproteomic analysis (HTP-GlycoMet)''


Norma sati: 6 mjeseci
- Guest researcher


Norma sati: 2 mjeseca
- Horizonte 2007


Norma sati: workshop
- Downstream Bioprocess Development (DEV 2)


Norma sati: workshop
- IBCs 5th International Single-Use Applications for Biopharmaceutical Manufacturing


Norma sati: workshop
- Croatian society of biotechnology, Bioprocess Engineering Course


Norma sati: workshop
- Marie Curie Research Training Network, Business Course I and II


Norma sati: workshop
- 1st CAPRI2010 Advanced Laboratory Workshop, Fc protein expression of type I and type II proteins


Norma sati: workshop
- "Entrepreneurship in Life Sciences" workshop


Norma sati: workshop
- "Becoming entrepreneurial: Knowledge transfer from the University Rijeka Faculty of Medicine to the biotechnology business sector", Training-workshop on commercial strategies MEDRI meets industry; IPA SIIF project


Norma sati: workshop
- "Becoming entrepreneurial: Knowledge transfer from the University of Rijeka Faculty of Medicine to the biotechnology business sector", Training-workshop on effective translation of vaccine R&D, IPA SIIF project


Norma sati: workshop
- "Becoming entrepreneurial: Knowledge transfer from the University of Rijeka Faculty of Medicine to the biotechnology business sector", Training on Preclinical testing opportunities, IPA SIIF project


Norma sati: workshop

Znanstvena i umjetnička djelatnost

Znanstveni radovi

1. Wagner, Felicia M; Brizic, Ilija; Prager, Adrian; Trsan, Tihana; Arapovic, Maja; Lemmermann, Niels AW; Podlech, Jürgen; Reddehase, Matthias J; Lemnitzer, Frederic; Bosse, Jens Bernhard;
The Viral Chemokine MCK-2 of Murine Cytomegalovirus Promotes Infection as Part of a gH/gL/MCK-2 Complex
PLoS pathogens 9 e1003493 - 2013.

2. Tršan, Tihana; Busche, Andreas; Abram, Maja; Wensveen, Felix M; Lemmermann, Niels A; Arapović, Maja; Babić, Marina; Tomić, Adriana; Golemac, Mijo; Brinkmann, Melanie M;
Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1?
Proceedings of the National Academy of Sciences 110 16550-16555 - 2013.

3. Lisnic, Vanda Juranic; Cac, Marina Babic; Lisnic, Berislav; Trsan, Tihana; Mefferd, Adam; Mukhopadhyay, Chitrangada Das; Cook, Charles H; Jonjic, Stipan; Trgovcich, Joanne;
Dual Analysis of the Murine Cytomegalovirus and Host Cell Transcriptomes Reveal New Aspects of the Virus-Host Cell Interface
PLoS pathogens 9 e1003611 - 2013.

4. Trsan, Tihana; Vukovic, Kristina; Filipovic, Petra; Lesac Brizic, Ana; Lemmermann Niels A.W.; Schober, Kilian; Busch, Dirk H.; Britt, William J.; Messerle Martin; Krmpotic Astrid; Jonjic Stipan
Cytomegalovirus vector expressing RAE-1? induces enhanced anti-tumor capacity of murine CD8+ T cells.
European Journal of Immunology doi: 10.1002/eji.201746964

5. Miletic, Antonija; Lenartic, Maja; Popovic, Branka; Brizic, Ilija; Trsan, Tihana; Miklic, Karmela; Mandelboim, Ofer; Krmpotic, Astrid; Jonjic, Stipan
NCR1-deficiency diminishes the generation of protective murine cytomegalovirus antibodies by limiting follicular helper T-cell maturation
European Journal of Immunology doi: 10.1002/eji.201646763

6. Jonjic Stipan; Trsan Tihana
Resistance to mousepox virus: CD94 on a special mission
Immunity 34 458-60

Kongresna priopćenja

1.
Tršan, T., Busche, A., Abram, M., Wensveen, F., Lemmermann, N.A., Arapović, M., Babić, M., Tomić, A., Golemac, M., Brinkmann, M.M., Jäger,W., Oxenius, A., Polić, B., Krmpotić, A., Messerle, M., Jonjić, S.
RAE-1? ligand expression by MCMV vector promotes induction and maintenance of protective immune memory poster NK 2013 14th Meeting of the Society for Natural Immunity Heidelberg, Germany
2.
Tršan, T., Abram, M., Lemmermann, N.A., Del Val, M., Krmpotić, A., Messerle, M., Jonjić, S.
CMV expressing NKG2D ligand RAE-1? employed as a highly immunogenic CD8 T cell vaccine-vector usmeno izlaganje 2014 Annual Meeting of the Croatian Immunological Society Krk, Croatia
3.
Tršan, T., Vuković, K., Filipović, P., Messerle, M., Krmpotić, A., Jonjić, S.
Cytomegalovirus vector expressing RAE-1? ligand serves a highly efficient anti-tumor CD8 T cell vaccine poster Annual Meeting of the Croatian Immunological Society Ogulin, Croatia
4.
Tršan, T., Busche, A., Abram, M., Wensveen, F., Lemmermann, N.A., Arapović, M., Babić, M., Tomić, A., Golemac, M., Brinkmann, M.M., Jäger,W., Oxenius, A., Polić, B., Krmpotić, A., Messerle, M., Jonjić, S.
RAE-1? ligand expression by MCMV vector promotes induction and maintenance of protective immune memory poster 2nd Meeting of Middle European Societies for Immunology and Allergology Opatija
5.
Slavuljica, I., Busche, A., Trsan T., Babic Cac, M., Mitrovic, M., Cekinovic, D., Juranic Lisnic, V., Krmpotic, A., Messerle, M., Jonjic, S.
Vaccine properties of a mouse CMV expressing ligand for the NKG2D receptor usmeno izlaganje 13th International BetaHerpesvirus Workshop. Nuremberg, Germany
6.
Tršan, T., Abram, M., Lemmermann, N.A., Del Val, M., Krmpotić, A., Messerle, M., Jonjić, S.
NKG2D ligand RAE-1? expressed by CMV vector promotes antigen presentation to CD8 T cells usmeno izlaganje IHW 2014 The 39th annual International Herpesvirus Workshop Kobe, Japan
7.
Tršan, T., Vuković, K., Lemmermann, N.A., Schober, K., Busch, D.H., Messerle, M., Krmpotić, A., Jonjić, S.
KLRG1+ CD8 T cells induced by cytomegalovirus vector expressing NKG2D ligand RAE-1? provide robust protection against tumor challenge usmeno izlaganje 16th International CMV / betaherpesvirus workshop Noordwijkerhout, Netherlands
8.
Tršan, T., Busche, A., Abram, M., Babić Čač, M., Golemac, M., Tomić, A., Krmpotić, A., Messerle, M., Jonjić, S.
RAE-1? expressed by recombinant herpesvirus dramatically improves its vector capacity and promotes specific immune response poster The 13th meeting of the Society for Natural Immunity NK2012. San Franscisco
9.
Tršan, T., Busche, A., Abram, M., Babić Čač, M., Tomić, A., Brinkmann, M., Krmpotić, A., Messerle, M., Jonjić, S.
Expression of NKG2D ligand by cytomegalovirus enhances its vaccine vector capacity poster Croatian Immunological Society Annual Meeting Marija Bistrica, Croatia
10.
Tršan, T., Abram, M., Lemmermann, N.A., Del Val, M., Krmpotić, A., Messerle, M., Jonjić, S.
CMV expressing NKG2D ligand RAE-1? employed as a highly immunogenic CD8 T cell vaccine-vector usmeno izlaganje 1st Croatian Virus Workshop CroViWo Rijeka, Croatia

Znanstveni projekti

1. -
''Molecular mechanisms of cytomegalovirus evasion from immune control (062-0621261-1263)'' ; Istraživač; Ministry of Science, Education and Sports of the Republic of Croatia; ;
2. -
''NK defense and therapy''; Activity assistant; Marie Curie Research Training Network MRTN-CT-2005-019248; ;
3. -
"Viral evasion of NK cells"; Activity assistant,; National Institutes of Health (NIH), SAD; ;
4. -
"Viral Strategies of Immune Evasion" (VISTRIE); Activity assistant; Helmholtz Association: Helmholtz Virtual Institutes; ;
5. -
''Becoming entrepreneurial: Knowledge transfer from the University of Rijeka Faculty of Medicine to the biotechnology business sector'' (IPA2007/HR/16IPO/001-040517); Activity assistant; Instrument for Pre-Accession Assistance (IPA), component III C, Science and Innovation I; ;
6. -
''Strengthening adaptive immunity via innate immunity: enhancing the CD8 T cell response by using the NKG2D ligand expressed in a herpesvirus vector (StAdvInn) (322693) ; Researcher; FP7 - European Research Council (ERC) Advanced Grant; ;
7. -
PACINNO Platform for trans-Academic Cooperation in Innovation ; Activity assistant; IPA Adriatic CBC 2007-2013; ;
8. -
Centre of Excellence for Research in Viral Immunology and the Development of New Vaccines - CERVirVac; Researcher; ; ;

Recenzije

1. 2011. Resistance to Mousepox Virus: CD94 on a Special Mission

Stručna djelatnost

Stručna aktivnost

1.
29.1.2015. -
sudjelovanje u organizaciji ''PACINNO Demo Day''
Step Ri: Znanstveno tehnologijski park Sveučilišta u Rijeci   suradnik
2.
11.9.2010. - 15.9.2010.
sudjelovanje u organizaciji ''12th Meeting of the Society for Natural Immunity & NK 2010''
Society for Natural Immunity   suradnik
3.
-
sudjelovanje u organizaciji međunarodnog skupa "10 years of Center for Proteomics"
Medicinski fakultet, Sveučilište u Rijeci   suradnik
4.
-
sudjelovanje u organizaciji ''2nd IPA SIIF project workshop: "Becoming entrepreneurial: Knowledge transfer from the University of Rijeka Faculty of Medicine to the biotechnology business sector", Training-workshop on effective translation of vaccine R&D''
Medicinski fakultet, Svečilište u Rijeci   suradnik