2009. - 2016.

Doktor znanosti

Poslijediplomski sveučilišni studij Biomedicina

Medicinski fakultet Sveučilišta u Rijeci

01.10.2002. - 30.01.2008.

Diplomirani sanitarni inženjer

Studij za diplomirane sanitarne inženjere

Medicinski fakultet, Sveučilište u Rijeci

01.07.2022. -

Docent

Medicinski fakultet u Rijeci

01.12.2016. - 30.06.2022.

Poslijedoktorand

Katedra za medicinsku kemiju, biokemiju i kliničku kemiju, Medicinski fakultet

01.12.2008. - 30.11.2016

Znanstveni novak - asistent

Katedra za medicinsku kemiju, biokemiju i kliničku kemiju, Medicinski fakultet

2023. -

Biokemija

Sveučilišni prijediplomski studij Medicinsko-laboratorijska dijagnostika

Medicinski fakultet u Rijeci

voditelj

2022. -

Biochemistry

Dental Medicine

Fakultet dentalne medicine Rijeka

suradnik

2022. -

BIochemistry II

University integrated undergraduate and graduate study programme of Medicine

Medicinski fakultet u Rijeci

Suradnik

2017. -

Biokemija

Dentalna medicina

Fakultet dentalne medicine Rijeka

suradnik

2012. - 2013.

Medicinska kemija i biokemija I

Integrirani preddiplomski i diplomski sveučilišni studij Medicina

Medicinski fakultet

suradnik

2011. -

Biokemija II

Integrirani preddiplomski i diplomski sveučilišni studij Medicina

Medicinski fakultet

suradnik

2010. -

Priručnik za seminare i vježbe iz biokemije za studente preddiplomskog studija sanitarnog inženjerstva

Financiranje: Medicnski fakultet Sveučilišta u Rijeci, Zavod za kemiju i biokemiju

2024.

Exosome-Derived microRNAs: Bridging the Gap Between Obesity and Type 2 Diabetes in Diagnosis and Treatment

Vukelić, Iva; Šuša, Branislav; Klobučar, Sanja; Buljević, Sunčica; Liberati Pršo, Ana-Marija; Belančić, Andrej; Rahelić, Dario; Detel, Dijana

Diabetology - 5 706-724

https://www.mdpi.com/2673-4540/5/7/52

Q2

2024.

The interplay of mitophagy, autophagy, and apoptosis in cisplatin-induced kidney injury: involvement of ERK signaling pathway /

Suman, Iva; Šimić, Lidija; Čanadi Jurešić, Gordana; Buljević, Sunčica; Klepac, Damir; Domitrović, Robert

Cell death discovery - 10 11

https://www.nature.com/articles/s41420-024-01872-0

Q1

2023.

Therapeutic Potential of BMP7 in the Treatment of Osteoporosis Caused by the Interaction between Inflammation and Corticosteroids in Inflammatory Bowel Disease

Smoljan, Ivana; Detel, Dijana; Buljevic, Suncica; Erjavec, Igor; Maric, Ivana

Biomedicines - 11 2161

https://www.mdpi.com/2227-9059/11/8/2161

Q1

2022.

CD26 Deficiency Controls Macrophage Polarization Markers and Signal Transducers during Colitis Development and Resolution

Vukelic, Iva ; Buljevic, Suncica ; Batičić, Lara ; Barisic, Karmela ; Franovic, Barbara ; Detel, Dijana

International journal of molecular sciences - 23 5506

https://www.mdpi.com/1422-0067/23/10/5506

Q1

21.09.2018.

Chlorogenic acid ameliorates experimental colitis in mice by suppressing signaling pathways involved in inflammatory response and apoptosis

Vukelić, Iva; Detel, Dijana; Pučar Batičić, Lara; Potočnjak, Iva; Buljević, Sunčica; Domitrović, Robert

Food and chemical toxicology - 121 140-150

https://www.sciencedirect.com/science/article/pii/S0278691518306185

Q1 WOS

02.07.2018.

The effect of CD26-deficiency on dipeptidyl peptidase 8 and 9 expression profiles in a mouse model of Crohn's disease

Buljevic, Suncica; Detel, Dijana; Pernjak Pugel, Ester; Varljen, Jadranka

Journal of cellular biochemistry - 119 6743-6755

https://onlinelibrary.wiley.com/doi/abs/10.1002/jcb.26867

Q2 WOS

26.02.2017.

Wound Healing Process, Diabetes and Implications of Dipeptidyl Peptidase IV (DPP IV/CD26).

Batičić Pučar, Lara; Kovač, Anja; Detel, Dijana; Buljević, Sunčica; Pernjak Pugel, Ester; Varljen, Jadranka

Journal of tissue science & engineering - 8

https://www.omicsonline.org/open-access/wound-healing-process-diabetes-and-implications-of-dipeptidyl-peptidase-iv-dpp-ivcd26-2157-7552-1000213-97300.html?view=mobile

2013.

Levels of dipeptidyl peptidase IV/CD26 substrates neuropeptide Y and vasoactive intestinal peptide in rheumatoid arthritis patients

Buljević, Sunčica; Detel, Dijana; Batičić Pučar, Lara; Mihelić, Radovan; Mađarević, Tomislav; Šestan, Branko; Varljen, Jadranka

Rheumatology International - 33 2867-2874

https://link.springer.com/article/10.1007%2Fs00296-013-2823-z

Q3

2012.

Is Dipeptidyl Peptidase IV (DPP IV) Associated with Inflammation Present in Human Spondyloarthritides and Rheumatoid Arthritis?

Detel, Dijana; Kehler, Tatjana; Buljević, Sunčica; Pavačić, Irena; Batičić Pučar, Lara; Varljen, Neven; Varljen, Jadranka

Croatica Chemica Acta - 85 231-238

http://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=125926

Q3

2012.

Relevance of DPP IV/CD26 among the Gut-brain Axis during Experimental Colitis

Batičić Pučar, Lara; Detel, Dijana; Buljević, Sunčica; Pernjak Pugel, Ester; Kučić, Natalia; Varljen, Jadranka

Croatica chemica acta - 85 201-208

http://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=125913

Q3

2012.

Decreased soluble dipeptidyl peptidase IV activity as a potential serum biomarker for COPD

Somborac Bačura, Anita; Buljević, Sunčica; Rumora, Lada; Čulić, Ognjen; Detel, Dijana; Pancirov, Dolores; Popović-Grle, Sanja; Varljen, Jadranka; Čepelak, Ivana; Žanić Grubišić, Tihana

Clinical biochemistry - 45 1245-1250

http://www.sciencedirect.com/science/article/pii/S0009912012002081?via%3Dihub

Q2

2012.

Development and resolution of colitis in mice with target deletion of dipeptidyl peptidase IV

Detel, Dijana; Pernjak Pugel, Ester; Batičić Pucar, Lara; Buljević, Sunčica; Varljen, Jadranka

Experimental physiology (0958-0670) 97 (2012), 4; - 97 486-496

http://onlinelibrary.wiley.com/doi/10.1113/expphysiol.2011.061143/abstract

Q2

27.06.2011.

Neuroimmunomodulative Properties of Dipeptidyl Peptidase IV/CD26 in a TNBS-induced Model of Colitis in Mice

Batičić, Lara; Detel, Dijana; Kučić, Natalia; Buljević, Sunčica; Pernjak Pugel, Ester; Varljen, Jadranka

Journal of cellular biochemistry - 112 3322-3333

http://onlinelibrary.wiley.com/doi/10.1002/jcb.23261/abstract

Q1 WOS

2011.

Role of Dipeptidyl Peptidase IV/CD26 in Inflammatory Bowel Disease

Detel, Dijana; Batičić Pučar, Lara; Pernjak Pugel, Ester; Kučić, Natalia; Buljević, Sunčica; Mijandrušić Sinčić, Brankica; Peršić, Mladen; Varljen, Jadranka

InTech

28.09.2022. - 01.10.2022.

DIFFERENT DYNAMICS OF DIABETIC WOUND HEALING IN CONDITIONS OF DIPEPTIDYL-PEPTIDASE IV (DPP IV/CD26) DEFICIENCY IN MICE

Batičić, Lara ; Detel, Dijana ; Buljević, Sunčica ; Bedoić, Edvard ; Kršek, Antea ; Varljen, Jadranka

Poster

HDBMB2022 - From Science to Knowledge Brela, Hrvatska

08.09.2022. - 01.10.2022.

CD26 deficiency modulates macrophage polarization via targeting of STAT proteins in a mouse model of ulcerative colitis

Buljević, Sunčica ; Vukelić, Iva ; Batičić, Lara ; Barišić, Karmela ; Franović, Barbara ; Detel, Dijana

Poster

HDBMB2022 - From Science to Knowledge Brela

26.09.2019.

In vivo expression profiles of dipeptidyl peptidases 8 and 9 in a mouse model of Crohn's disease

Suncica Buljevic, Ester Pernjak Pugel, Jadranka Varljen, Lara Baticic, Karmela Barisic i Dijana Detel

Poster

HDBMB2019 Crossroads in Life Sciences Lovran

24.10.2014. - 27.10.2014.

Immunomodulatory properties of dipeptidyl peptidase IV (DPP IV/CD26) in an experimental model of ulcerative colitis

Detel, Dijana ; Batičić Pučar, Lara ; Pernjak Pugel, Ester ; Buljević, Sunčica ; Varljen, Jadranka

Poster

The Interplay of Biomolecules - HDBMB2014 Zadar

06.07.2013. - 11.07.2013.

Deficiency of DPP IV/CD26 Impacts Vasoactive Intestinal Peptide Levels among the Gut-brain Axis in Acute Inflammation

Batičić Pučar, Lara ; Detel, Dijana ; Buljević, Sunčica ; Kučić, Natalia ; Jadranka Varljen

Poster

Federation of European Biochemical Societies Congress 2013 “Mechanisms in Biology” Sankt Petersburg

13.06.2012. - 16.06.2012.

Dipeptidyl peptidase IV affects neruopeptide Y levels in inflammatory events

Buljević, Sunčica; Batičić Pučar, Lara; Detel, Dijana; Mihelić Radovan; Kučić, Natalia; Varljen, Jadranka

Usmena prezentacija

FEBS3+Meeting "From molecules to life and back" Opatija

Postoji li povezanost aktivnosti dipeptidil-peptidaze IV i upale prisutne u reumatoidnom artritisu i spondiloartropatijama?( Is dipeptidyl peptidase IV activity associated with inflammation present in human rheumatoid arthritis and spondyloarthropaties? )

Detel, Dijana; Kehler, Tatjana; Buljević, Sunčica; Pavačić, Irena; Batičić, Lara; Varljen, Neven; Varljen, Jadranka

Thermal and barrier characterisation of polyethylene film as food packaging material

Valić, Srećko; Ostojić, Sunčica; Kurek, Mia; Klepac, Damir; Galić, Kata

Fatty Acid Composition of Diplodus Vulgaris, L. from the Kvarner Bay

Ostojić, Sunčica; Batičić, Lara; Varljen, Neven; Kapović, Miljenko; Varljen, Jadranka

Activation of NK and NKT Cells during Experimental Colitis in CD26 Deficient Mice

Detel, Dijana; Kučić, Natalia; Batičić, Lara; Ostojić, Sunčica; Varljen, Jadranka

Is dipeptidyl peptidase IV activity associated with inflammation present in human rheumatoid arthritis and spondyloarthropaties?

Detel, Dijana; Kehler, Tatjana; Ostojić, Sunčica; Pavačić, Irena; Batičić, Lara; Varljen, Neven; Varljen, Jadranka

Could vasoactive intestinal peptide be a VIP substrate of dipeptidyl peptidase IV (DPP IV/CD26) involved in experimental murine colitis?

Batičić, Lara; Detel, Dijana; Ostojić, Sunčica; Kučić, Natalia; Varljen, Jadranka

Proinflammatory role of dipeptidyl peptidase IV in patients with chronic obstructive pulmonary disease

Somborac, Anita; Pancirov, Dolores; Ostojić, Sunčica; Detel, Dijana; Varljen, Jadranka; Čepelak, Ivana; Žanić Grubišić, Tihana

Impact of DPP IV/CD26 Deficiency on Neuropeptide Y among the Gut-brain Axis in Experimental Colitis

Batičić Pučar, Lara; Detel, Dijana; Buljević, Sunčica; Kučić, Natalia; Varljen, Jadranka

19.-20.09.2019.

Chlorogenic acid ameliorates experimental colitis in mice by suppressing signaling pathways involved in inflammatory response and apoptosis

Iva Vukelić, Dijana Detel, Lara Batičić, Iva Potočnjak, Sunčica Buljević, Robert Domitrović

Usmena prezentacija, poster prezentacija

1st International Doctoral Scientific Conference "Innovative Technologies in Biomedicine" Rijeka, Croatia

13.06.2012. - 16.06.2012.

FEBS 3+ Meeting “From molecules to life and back”

Opatija Član lokalnog organizacijskog odbora

15.09.2010. - 18.09.2010.

10. Kongres Hrvatskog društva za biokemiju i molekularnu biologiju “Tajni život biomolekula"

Opatija Član Organizacijskog odbora

2022. - 2023.

Utjecaj CD26 deficijencije na signalne puteve neuropeptida PYY i SP u eksperimentalnome modelu Crohnove bolesti 

Voditeljica

Medicinski fakultet u Rijeci 20 000 kn

2019. - 2023.

Uloga novootkrivenih proteaza u razvoju i progresiji tumora debelog crijeva

Suradnica

Sveučilište u Rijeci 23.404,91 kn

2019. - 2022.

Interakcija lijekova i fitokemikalija in vitro i in vivo: uloga FOXO signalnog puta

Suradnica

Sveučilište u Rijeci 45.346,78 kn

2017. - 2018.

Interakcija DP8 i 9 proteina i makrofaga u upali i regeneraciji

Voditeljica

Sveučilište u Rijeci 17.000 kn

2013. - 2017.

Uloga proteina obitelji DPP IV u kroničnim bolestima

Suradnca

Sveučilište u Rijeci;

2012. - 2013.

Mycoplasma involvement in autoimmune processes of rheumatoid arthritis and evaluation of new possible diagnostic markers

Suradnik

Ministarstvo znanosti, obrazovanja i sporta, Hrvatsko-slovenski bilateralni projekt

2007. - 2013.

Uloga molekule dipeptidil-peptidaze IV (CD26/DPP IV) u kroničnim bolestima

Suradnica

Ministarstvo znanosti, obrazovanja i sporta Republike Hrvatske 90.000 kn

2006. - 2013.

Uloga dipeptidil-peptidaze IV (CD26/DPP IV) u kroničnim bolestima

Znanstveni novak

Ministarstvo znanosti, obrazovanja i sporta