Doc. dr. sc. Daniela Kalafatović

Odjel za biotehnologiju Zavod za molekularnu i sistemsku biomedicinu

telefon : 584-588
prostorija : O-810



MEĐUNARODNA VIDLJIVOST:
CITATIH-INDEXI10-INDEX
Google Scholar
ORCID ID
Publons

Obrazovanje

- Doktorat znanosti WestChem, Pure and Applied Chemistry University of Strathclyde
- Mag. Farm. Sveučilišni studij Farmacije, smjer farmaceutska kemija i tehnologija Sveučilište u Trstu

Radno iskustvo

1.8.2019. - Docent Sveučilište u Rijeci, Odjel za Biotehnologiju
9.3.2016. - 31.3.2018. Poslijedoktorand (eng. Post-doctoral fellow, Marie-Curie COFUND) Glavni projekt: "Combinatorial peptide libraries for metastatic breast cancer therapy". Znanstvena istraživanja u multidisciplinarnom području medicinske kemije (Chemistry and molecular pharmacology program) i onkologije (Oncology program), suradnja sa Hospital Clinic Barcelona u području antimikrobnih peptida za tretman rezistentnih bakterija, mentorstvo studentu (Laura López Ruiz) zavrsne godine preddiplomskog studija u području medicinske kemije peptida za terapiju rijetke bolesti Friedreich ataxie, u suradnji sa Universidad Autonoma de Madrid, sudjelovanje u programu popularizacije znanosti (Crazy about Biomedicine program, 2017), sudjelovanje u radionicama o poduzetništvu i sastancima IRB Barcelona Innovation tima s ciljem pronalaska poslovnih ideja i kreacije poslovnih planova za potencijalne start-up kompanije. Institute for Research in Biomedicine (IRB), Barcelona, Španjolska
1.2.2015. - 1.2.2016. Znanstveni suradnik (eng. Research Associate) Glavni projekt: "Self-assembled nanomaterials for selective cancer targeting". Znanstvena istraživanja u interdisciplinarnom području supramolekularne kemije i nanotehnologije peptida (peptide self-assembly), postavljanje laboratorija i sudjelovanje u opsežnim treninzima novih članova grupe, uključujući doktorande i post-doktorande. Vođenje postrojenja za sintezu peptida (eng. Peptide synthesis facility). Suradnja pri organizaciji jednodnevnih simpozija i konferencija, za izdvojiti je dobiveno sponzorstvo tvrtke CEM za događaj "Soft Nano" održan u ASRC-u. Nanoscience initiative, Advanced Science Research Centre (ASRC) at The Graduate Center of the City University of New York, SAD
10.1.2011. - 30.6.2014. Znanstveni novak (eng. PhD student) Glavni projekt: "Enzyme responsive nanomaterials for cancer applications". Znanstvena istraživanja u interdisciplinarnom području supramolekularne kemije i nanotehnologije peptida (peptide self-assembly). Ko-mentorstvo gostujuće studentice (Rachel Kane) u okviru programa popularizacije znanosti «Nuffield Research Placements»; sudjelovanje u organizaciji međunarodnih skupova, prezentiranje na međunarodnim konferencijama. WestCHEM, Department of Pure & Applied Chemistry, University of Strathclyde, Glasgow

Nagrade i priznanja

Domino Macro Group Young Researcher 2013 za drugo najbolje usmeno izlaganje na međunarodnoj znanstvenoj konferenciji Macro Group Young Researchers Meeting (2013., Nottingham, UK)
NAGRADA za najbolji poster na međunarodnoj znanstvenoj konferenciji Nanoscience NY Conference 2015 (2015., New York, SAD); https://nanoscienceny.com/nanoscience/index.htm

Nastavna djelatnost

Kolegiji

- Instrumetalne metode kemijske analize
Diplomski sveučilišni studij "Medicinska kemija"
Sveučilište u Rijeci, Odjel za Biotehnologiju
Nositelj kolegija
Norma sati:

Znanstvena i umjetnička djelatnost

Znanstveni radovi

1. Daniela Kalafatovic, Ernest Giralt
Cell-penetrating peptides: Design strategies beyond primary structure and amphipathicity
Molecules 22 1929 - 2017. https://www.mdpi.com/1420-3049/22/11/1929

Q2

2. Daniela Kalafatovic, Max Nobis, Jiye Son, Kurt I Anderson, Rein V Ulijn
MMP-9 triggered self-assembly of doxorubicin nanofiber depots halts tumor growth
Biomaterials 98 192-202 - 2016. https://www.sciencedirect.com/science/article/pii/S0142961216301582

Q1
Exc

3. Pim WJM Frederix, Gary G Scott, Yousef M Abul-Haija, Daniela Kalafatovic, Charalampos G Pappas, Nadeem Javid, Neil T Hunt, Rein V Ulijn, Tell Tuttle
Exploring the sequence space for (tri-) peptide self-assembly to design and discover new hydrogels
Nature chemistry 7 30 - 2015. https://www.nature.com/articles/nchem.2122

Q1
Exc

4. Daniela Kalafatovic, Goran Mauša, Toni Todorovski, Ernest Giralt
Algorithm-supported, mass and sequence diversity-oriented random peptide library design
Journal of cheminformatics 11 25 https://jcheminf.biomedcentral.com/articles/10.1186/s13321-019-0347-6

Q2

5. Jiye Son, Daniela Kalafatovic, Mohit Kumar, Barney Yoo, Mike A Cornejo, María Contel, Rein V Ulijn
Customizing Morphology, Size, and Response Kinetics of Matrix Metalloproteinase-Responsive Nanostructures by Systematic Peptide Design
ACS nano 13 1555-1562 https://pubs.acs.org/doi/abs/10.1021/acsnano.8b07401

Q1
Exc

6. Sylwia Gawrzak, Lorenzo Rinaldi, Sara Gregorio, Enrique J Arenas, Fernando Salvador, Jelena Urosevic, Cristina Figueras-Puig, Federico Rojo, Ivan del Barco Barrantes, Juan Miguel Cejalvo, Marta Palafox, Marc Guiu, Antonio Berenguer-Llergo, Aikaterini Symeonidi, Anna Bellmunt, Daniela Kalafatovic, Anna Arnal-Estape, Esther Fernandez, Barbara Müllauer, Rianne Groeneveld, Konstantin Slobodnyuk, Camille Stephan-Otto Attolini, Cristina Saura, Joaquin Arribas, Javier Cortes, Ana Rovira, Montse Munoz, Ana Lluch, Violeta Serra, Joan Albanell, Aleix Prat, Angel R Nebreda, Salvador Aznar Benitah, Roger R Gomis
MSK1 regulates luminal cell differentiation and metastatic dormancy in ER+ breast cancer
Nature Cell Biology 20 211 https://www.nature.com/articles/s41556-017-0021-z

Q1
Exc

7. B. R. Saunders and R. V. Ulijn D. Kalafatovic, M. Nobis, N. Javid, P. W. J. M. Frederix, K. I. Anderson
MMP-9 triggered micelle-to-fibre transitions for slow release of doxorubicin
Biomaterials Science 3 246-249 https://pubs.rsc.org/en/content/articlelanding/2015/BM/C4BM00297K#!divAbstract

Q1

8. Charalampos G Pappas, Pim WJM Frederix, Tapiwa Mutasa, Scott Fleming, Yousef M Abul-Haija, Sharon M Kelly, Anthony Gachagan, Daniela Kalafatovic, Jacob Trevino, Rein V Ulijn, Shuo Bai
Alignment of nanostructured tripeptide gels by directional ultrasonication
Chemical communications 51 8465-8468 https://pubs.rsc.org/en/content/articlelanding/2015/CC/C5CC02049B#!divAbstract

Q1

Kongresna priopćenja

1.
J. Moreno Morales, D. Kalafatovic, C. Ballesté, E. Giralt, J. Vila Estape.
Antimicrobial activity evaluation of newly designed antimicrobial peptides against multidrug-resistant bacteria Poster European Congress of Clinical Microbiology and Infectious Diseases Madrid, Španjolska - 23.4.2018. https://www.escmid.org/escmid_publications/escmid_elibrary/?q=kalafatovic&id=2173&L=0&x=0&y=0&tx_solr%5Bsort%5D=relevance%2Basc&tx_solr%5Bfilter%5D%5B0%5D=main_filter_eccmid%253Atrue&tx_solr%5Bfilter%5D%5B1%5D=pub_date%253A201801010000-201812312359&tx_sol
2.
Kalafatovic, Daniela; Llorente, Alicia; Teixido, Meritxell; Gomis, Roger; Giralt, Ernest
OBOC combinatorial peptide libraries for identification of targetable membrane proteins as bone metastasis mediators in breast cancer Poster 12th Australian Peptide Symposium Peppers Noosa Resort, Queensland, Australija - 16.10.2017. http://peptides-2017.p.asnevents.com.au/days/2017-10-16/abstract/46123
3.
D. Kalafatovic, M. Nobis, K. I. Anderson and R. V. Ulijn
MMP-9 responsive peptides for tumor associated formation of doxorubicin releasing nanofibres Poster Soft Nano NY Advanced Science Research Center, City University, New York, NY, SAD - 18.6.2015. http://www.nanoscienceny.com/softnano/posterabs.htm
4.
D. Kalafatovic, M. Nobis, Kurt I. Anderson and R. V. Ulijn
MMP-9 responsive peptides for tumor associated formation of doxorubicin releasing nanofibres Predavanje BioDesign MegaMeeting Center for Integrative Proteomics Research, Rutgers University, New Jersey, SAD - 17.4.2015.
5.
D. Kalafatovic, M. Nobis, K. I. Anderson and R. V. Ulijn
MMP-9 responsive peptides for tumor associated formation of doxorubicin releasing nanofibres Poster Nanoscience NY Advanced Science Research Center, City University, New York, NY, SAD - 19.2.2015.
6.
Kalafatovic, D.; Nobis, M; Anderson, K. I.; Ulijn, R.V.
MMP-9 triggered reconfiguration of supramolecular peptide amphiphiles for controlled release Predavanje Peptide Materials for Nanotechnology and Biomedicine (PepMat 2013) Sorrento, Italija - 30.10.2013. http://www.yesmeet.com/congressi/peptidematerials2013/www.peptidematerials2013.org/en/index.php.html
7.
Kane, R.; Leckie, J.; Kalafatovic, D.; Garety, L.; Ulijn, R.V.
Enzymatic release of a model drug from peptide micelles Poster Nuffield Bursary Scheme for Schools & Colleges Scotland, Royal College of Physician Edinburgh, UK - 6.9.2013.
8.
Kalafatovic, D.; Ulijn, R. V.
MMP-9 triggered reconfiguration of supramolecular peptide systems Predavanje Macro Group Young Researchers Meeting Nottingham, UK - 25.6.2013.
9.
Kalafatovic, D.; Ulijn, R.V
Enzyme responsive microgels Poster University of Strathclyde Research Day 2012 Glasgow, UK - 7.6.2012.
10.
Kalafatovic, D.; Saunders, B.R.; Ulijn, R. V.
Enzyme responsive microgels Poster Macro Group UK International Conference on Polymer Synthesis and UKPCF International Conference on Polymer Colloids Warwick, UK
11.
Kalafatovic, D.; Saunders, B.R.; Ulijn, R. V.
Enzyme responsive microgels Poster RSC Polymeric and Self-Assembled Hydrogels London, UK
12.
Kalafatovic, D; Nobis, M; Anderson, K. I.; Ulijn, R. V.
MMP-9 responsive peptides for tumor associated formation of doxorubicin releasing nanofibres Poster American Peptide Symposium Orlando, Florida, USA
13.
Kalafatovic, D.; Nobis, M.; Anderson, K. I.; Ulijn, R. V.
MMP-9 responsive peptides for tumor associated formation of doxorubicin releasing nanofibres Poster RSC Challenges in Nanoscience University of California San Diego (San Diego, USA)
14.
Kalafatovic, D; Nobis, M; and Ulijn, R. V.
MMP-9 triggered reconfiguration of supramolecular peptide amphiphiles Poster Macrocyclic and Supramolecular Chemistry Meeting Glasgow, UK
15.
Mauša, Goran; Kalafatovic, Daniela; Giralt, Ernest; Galinac Grbac, Tihana
Decision Support System for Combinatorial Peptide Libraries Poster ENABLE Symposium 2017 Barcelona, Španjolska https://enablenetwork.eu/wp-content/uploads/2017/11/ENABLE-BCN2017-Abstract-Book.pdf
16.
Kalafatovic, D.; Ulijn, R. V
Enzyme responsive materials for controlled release Poster Directed Assembly of Functional Nanomaterials: Design, control and manufacture Glasgow, UK
17.
D. Kalafatovic, A. Llorente, M. Teixido, E. Giralt and R. Gomis
OBOC combinatorial peptide libraries for identification of targetable membrane proteins as bone metastasis mediators in breast cancer Poster Barcelona BioMed Conference: Mechanisms of Metastasis Barcelona, Španjolska

Znanstveni projekti

1. 18.3.2020. -
Računalni model strujanja, poplavljivanja i širenja onečišćenja u rijekama i obalnim morskim područjima; Član tima ; Europski fond za regionalni razvoj (EFRR); ; https://strukturnifondovi.hr/natjecaji/shema-za-jacanje-primijenjenih-istrazivanja-za-mjere-prilagodbe-klimatskih-promjena/
2. 1.2.2020. - 31.1.2025.
Dizajn katalitički aktivnih peptida i peptidnih nanostruktura; Voditelj ; HRZZ; 1,999,600.00;
3. 8.3.2016. - 31.3.2018.
Marie-Curie COFUND (IRB Barcelona); Post-doc (suradnik); EU commission; ;