11.11.2014. - 13.02.2020.

Doktorica znanosti

Poslijediplomski doktorski studj Biomedicina

Sveučilište u Rijeci, Medicinski fakultet

01.10.2011. - 05.07.2013.

Magistra sanitarnog inženjerstva, mag. sanit. ing.

Diplomski sveučilišni studij Sanitarno inženjerstvo

Sveučilište u Rijeci, Medicinski fakultet

01.10.2008. - 16.09.2011.

Sveučilišna prvostupnica (baccalaurea) sanitarnog inženjerstva, univ. bacc. sanit. ing.

Preddiplomski sveučilišni studij Sanitarno inženjerstvo

Sveučilište u Rijeci, Medicinski fakultet

15.11.2021. -

Viši asistent, Zavod za medicinsku kemiju, biokemiju i klinicku kemiju

Održavanje nastave i znanstveni rad

Medicinski fakultet Sveučilišta u Rijeci

01.10.2014. - 15.11.2021.

Asistent, Zavod za medicinsku kemiju, biokemiju i kliničku kemiju

Održavanje nastave i znanstveni rad

Medicinski fakultet Sveučilišta u Rijeci

03.09.2014. - 30.09.2014.

Stručno osposobljavanje bez zasnivanja radnog odnosa

Stručno osposobljavanje u Zdravstveno – ekološkom odjelu, fizikalno-kemijske analize voda

Nastavni ZAVOD ZA JAVNO ZDRAVSTVO PRIMORSKO-GORANSKE ŽUPANIJE

20.11.2013. - 03.04.2014.

Sanitarni tehničar

Izvršitelj poslova dezinsekcije, dezinfekcije i deratizacije

DEZINSEKCIJA PUNTAMIKA j.d.o.o.

9.6.2022. - 14.6.2022.

FEBS bursary for The Biochemistry Global Summit, Lisabon, Portugal

02.09.2018.

FEBS Junior Fellowship for FEBS3 Balaton 2018 Conference

14.07.2016.

Grant for Young Scientists Program and 16th IUBMB Conference, Vancouver, BC, Canada

16.09.2015.

Grant for FEBS3+ Meeting »Molecules of Life«, Portorož, Slovenia

2015. -

Croatian Society of Biochemistry and Molecular Biology

2023.

Sinomenine mitigates cisplatin-induced kidney injury by targeting multiple signaling pathways

I Potočnjak, L Šimić, L Batičić, H Križan, R Domitrović,

Food and Chemical Toxicology - 171

Q1

2022.

Oleanolic acid induces HCT116 colon cancer cell death through the p38/FOXO3a/Sirt6 pathway

I Potočnjak, L Šimić, I Vukelić, L Batičić, R Domitrović

Chemico-Biological Interactions - 363

Q1

2020.

Luteolin ameliorates experimental colitis in mice through ERK-mediated suppression of inflammation, apoptosis and autophagy

Vukelić, Iva; Detel, Dijana; Batičić, Lara; Potočnjak, Iva; Domitrović, Robert;

Food and Chemical Toxicology - 111680

Q1

2020.

Aucubin administered by either oral or parenteral route protects against cisplatin-induced acute kidney injury in mice

Potočnjak, Iva; Marinić, Jelena; Batičić, Lara; Šimić, Lidija; Broznić, Dalibor; Domitrović, Robert;

Food and Chemical Toxicology - 111472

Q1

2020.

Antitumor activity of luteolin in human colon cancer SW620 cells is mediated by the ERK/FOXO3a signaling pathway

Potočnjak, Iva; Šimić, Lidija; Gobin, Ivana; Vukelić, Iva; Domitrović, Robert;

Toxicology in Vitro - 104852

Q1

2019.

Oleanolic acid attenuates cisplatin-induced nephrotoxicity in mice and chemosensitizes human cervical cancer cells to cisplatin cytotoxicity

Potočnjak, Iva; Šimić, Lidija; Vukelić, Iva; Domitrović, Robert;

Food and Chemical Toxicology - 132 110676

Q1

2018.

Chlorogenic acid ameliorates experimental colitis in mice by suppressing signaling pathways involved in inflammatory response and apoptosis

Vukelić, Iva; Detel, Dijana; Pučar, Lara Batičić; Potočnjak, Iva; Buljević, Sunčica; Domitrović, Robert;

Food and chemical toxicology - 121 140-150

Q1

2018.

Carvacrol induces cytotoxicity in human cervical cancer cells but causes cisplatin resistance: involvement of MEK-ERK activation

Potočnjak, Iva ; Gobin, Ivana ; Domitrović, Robert

Phytotherapy research - 32 1090-1097

Q1

2017.

Stevia and stevioside protect against cisplatin nephrotoxicity through inhibition of ERK1/2, STAT3, and NF-?B activation

Potočnjak, Iva ; Broznić, Dalibor ; Kindl, Marija ; Kropek, Matija ; Vladimir-Knežević, Sanda ; Domitrović, Robert

Food and chemical toxicology - 107 215-225

Q1 WOS WOS

2016.

Carvacrol attenuates acute kidney injury induced by cisplatin through suppression of ERK and PI3K/Akt activation

Potočnjak, Iva ; Domitrović, Robert

Food and chemical toxicology - 98 251-261

Q1 WOS WOS

2016.

Oral administration of oleuropein attenuates cisplatin-induced acute renal injury in mice through inhibition of ERK signaling

Potočnjak, Iva ; Škoda, Marko ; Pernjak-Pugel, Ester ; Pavletić Peršić, Martina ; Domitrović, Robert

Molecular nutrition & food research - 60 530-541

Q1 WOS WOS

2016.

A comprehensive overview of hepatoprotective natural compounds: mechanism of action and clinical perspectives

Domitrović, Robert ; Potočnjak, Iva

Archives of toxicology - 90 39-79

Q1 WOS WOS

2014.

Terminalia bellerica aerial parts ethyl acetate extract exhibits antioxidant, anti-inflammatory and antifibrotic activity in carbon tetrachloride- intoxicated mice

Rashed, Khaled ; Potočnjak, Iva ; Giacometti, Jasminka ; Škoda, Marko ; Domitrović, Robert

Journal of functional foods - 8 319-330

Q1 WOS WOS

2014.

Nephroprotective activities of rosmarinic acid against cisplatin-induced kidney injury in mice

Domitrović, Robert ; Potočnjak, Iva ; Crnčević- Orlić, Željka ; Škoda, Marko

Food and chemical toxicology - 66 321-328

Q1 WOS WOS

3.10.2015.

Liver steatosis and metabolic syndrome: mechanisms of therapeutic effects of phytochemicals

Domitrović R, Potočnjak I.

7th Congress of endocrinology, Lovran, Croatia, October 1-4, 2015.

3.10.2021. - 6.10.2021.

Aucubin administered by either oral or parenteral route protects against cisplatin-induced acute kidney injury in mice

Potočnjak I., Marinić J, Batičić L, Šimić L, Broznić D, Domitrović R.

Poster prezentacija

6th Croatian Congress of Toxicology CROTOX 2021 Rabac, Hrvatska

https://hrcak.srce.hr/broj/20925

24.9.2021.

Oleanolic acid induces mitophagy and chemosenzitises human colon carcinoma cells

Potočnjak I, Šimić L, Vukelić I, Domitrović R.

Poster prezentacija

X Conference of the Serbian Biochemical Society Kragujevac, Srbija

https://www.bds.org.rs/download/X_Konferencija_zbornik.pdf

3.7.2021. - 8.7.2021.

Aucubin administered by either oral or parenteral route protects against cisplatin-induced acute kidney injury in mice

Potočnjak I., Marinić J, Batičić L, Šimić L, Broznić D, Domitrović R.

Poster prezentacija

45th FEBS Congress Ljubljana, Slovenia

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8251645/pdf/FEB4-11-103.pdf

25.9.2019. - 28.9.2019.

Oleanolic acid attenuates cisplatin-induced nephrotoxicity in mice through regulation of multiple signalling pathways

Potočnjak I, Šimić L, Vukelić I, Domitrović R

Poster prezentacija

HDBMB2019 - CROSSROADS IN LIFE SCIENCES, 2019. Lovran, Hrvatska

https://www.bib.irb.hr/1054718

19.9.2019. - 20.9.2019.

Oleanolic acid attenuates cisplatin-induced nephrotoxicity in mice and chemosensitizes human cancer cells to cisplatin cytotoxicity

Potočnjak I, Šimić L, Vukelić I, Domitrović

Predavanje i poster prezentacija

AARC DOCTORAL CONFERENCE Innovative Technologies in Biomedicine Rijeka, Hrvatskja

https://www.bib.irb.hr/1163186

05.09.2018.

Delphinidin aggravates cisplatin-induced nephrotoxicity by augmenting renal oxidative stress, inflammation, and apoptosis

Potočnjak, Iva ; Vukelić, Iva ; Marinić, Jelena ; Škoda, Marko ; Domitrović, Robert

Poster

FEBS3+ conference ‘From molecules to living systems’2018 Siófok, Hungary

Preuzeto sa:https://bib.irb.hr/prikazi-rad?&rad=953740

22.04.2017.

Carvacrol protects human cervical cancer cells against cisplatin- induced cytotoxicity through multiple ERK-dependent mechanisms

Potočnjak, Iva ; Gobin, Ivana ; Domitrović, Robert

Poster

25th Croatian Meeting of Chemists and Chemical Engineers with international participation, 3rd symposium “Vladimir Prelog” Poreč, Hrvatska

Preuzeto sa:https://bib.irb.hr/prikazi-rad?&rad=889672

21.07.2016.

Carvacrol attenuates acute kidney injury induced by cisplatin through suppression of MAPK and PI3K/Akt pathways

Potočnjak, Iva ; Domitrović, Robert ; Gobin, Ivana

Poster

16th International Conference of Biochemistry and Molecular Biology Vancouver, Kanada

Preuzeto sa:https://bib.irb.hr/prikazi-rad?&rad=832434

21.07.2016.

Carvacrol attenuates acute kidney injury induced by cisplatin through suppression of MAPK and PI3K/Akt pathways

Potočnjak, Iva ; Domitrović, Robert ; Gobin, Ivana

Predavanje

Young Scientists Program as a satellite meeting of 16th IUBMB Conference Vancouver, Kanada

Preuzeto sa:https://bib.irb.hr/prikazi-rad?&rad=889673

19.09.2015.

Oleuropein ameliorates cisplatin-induced oxidative damage, inflammation and apoptosis in mice kidneys by modulating CYP2E1, NF-?B and ERK1/2 expression

Domitrović, Robert ; Potočnjak, Iva ; Škoda, Marko ; Pavletić Peršić, Martina

Poster

FEBS3+ Meeting (2015) ; Meeting of the Slovenian Biochemical Society (11 ; 2015) Portorož, Slovenija

Preuzeto sa:https://bib.irb.hr/prikazi-rad?&rad=824756

2021. - 2022.

Biomolecules, MDPI, Special Issue "Cisplatin in Diseases: Molecular Mechanisms of Action"

https://www.mdpi.com/journal/biomolecules/special_issues/Cisplatin_Dis

20.4.2021. - 19.04.2022.

Modulacija MEK-ERK MAPK signalnog puta u CP-induciranoj mitofagiji u bubrezima

Voditelj

Sveučilište u Rijeci 45.317,36 HRK

https://pdb.irb.hr/project/7067

2019. - 2022.

Interakcija lijekova i fitokemikalija in vitro i in vivo: uloga FOXO signalnog puta

Suradnik

Sveučilište u Rijeci 135.549,00 HRK

https://pdb.irb.hr/project/6636

2019. - 2020.

Uloga novootkrivenih proteaza u razvoju i progresiji tumora debelog crijeva

Suradnik

Sveučilište u Rijeci 66.479,99 HRK

https://pdb.irb.hr/project/irb:006520

2019. -

Razvoj kompozitnih polimernih nanovlakana za kontrolirano otpuštanje lijekova

Suradnik

bilateralna suradnja s Kinom

2014. - 2018.

Međudjelovanje fitokemikalije i lijekova in vivo: modulacija nefrotoksičnosti cisplatina

Suradnik

Sveučilište u Rijeci 205.735,08 HRK

https://pdb.irb.hr/project/irb:007799