UNIRI | Milan Mesić

2013

Conformational properties and chiral separation of dibenzo [b, f] thieno [3, 4-d]-fused oxepines and thiepines

Landek, Goran; Ozimec Landek, Ivana; Pešić, Dijana; Mesić, Milan; Šunjić, Vitomir;

Monatshefte für Chemie-Chemical Monthly - 144

2023

Different chemical proteomic approaches to identify the targets of lapatinib

Kovačević, Tatjana; Nujić, Krunoslav; Cindrić, Mario; Dragojević, Snježana; Vinter, Adrijana; Hozić, Amela; Mesić, Milan;

Journal of enzyme inhibition and medicinal chemistry - 38

2011

Primjena znanstvenih rezultata u proizvodnji Kemija u tvrtki Galapagos istraživački centar doo

Gabelica Marković, Vesna; Mesić, Milan; Alihodžić, Sulejman; Kovačević, Krunoslav;

Kemija u industriji: Časopis kemičara i kemijskih inženjera Hrvatske - 60

2011

Synthesis and anti‐inflammatory activity of 8H‐1‐thia‐8‐aza‐dibenzo [e, h] azulenes

Ozimec Landek, Ivana; Pešić, Dijana; Merćep, Mladen; Stanić, Barbara; Mesić, Milan;

Journal of heterocyclic chemistry - 48

2011

Applying Research Results to Production Chemistry in the Galapagos Research Center Ltd., Zagreb

Gabelica Marković, V; Mesić, M; Alihodžić, S; Kovačević, K;

Kemija u industriji: Časopis kemičara i kemijskih inženjera Hrvatske - 60

2013

2D versus 3D cell culture platforms for screening antitumoral activity of novel chemical entities

Trzun, Marija; Paravić Radičević, Andrea; Frka Borić, Kosjenka; Jelić, Dubravko; Vujasinović, Ines; Mesić, Milan; Eraković Haber, Vesna; Brajša, Karmen;

Functional Analysis and screening technologies

2013

Synthesis and anti-inflammatory activity of novel furochromenes

Elenkov, Ivaylo Jivkov; Hrvačić, Boška; Marković, Stribor; Mesić, Milan; Čempuh Klonkay, Andreja; Lerman, Lidija; Filipović Sučić, Anita; Vujasinović, Ines; Bošnjak, Berislav; Brajša, Karmen;

Croatica chemica acta - 86

2013

Differences in anticancer drug sensitivities in 3D and 2D cancer cell culture systems: model on ADAM10 novel anticancer drug target and biomarker

Trzun, Marija; Paravić Radičević, Andrea; Frka Borić, Kosjenka; Jelić, Dubravko; Vujasinović, Ines; Mesić, Milan; Eraković Haber, Vesna; Brajša, Karmen;

Functional Analysis and screening technologies

2018

Methods for arylethylation of amines and heteroarenes

Bracher, Franz;

SynOpen - 2

2011

Determination of aqueous stability and degradation products of series of coumarin dimers

Dragojević, Snježana; Šunjić, Vitomir; Bencetić-Mihaljević, Vlatka; Ralić, Jovica; Mesić, Milan; Elenkov, Ivaylo Jivkov; Sučić, Anita Filipović; Klonkay, Andreja Čempuh; Lerman, Lidija; Ilijaš, Marina;

Journal of pharmaceutical and biomedical analysis - 54

2019

Benzoxaboroles—novel autotaxin inhibitors

Kraljić, Kristina; Jelić, Dubravko; Žiher, Dinko; Cvrtila, Adam; Dragojević, Snježana; Sinković, Verona; Mesić, Milan;

Molecules - 24

2013

Macrolactonolides: a novel class of anti-inflammatory compounds

Tomašković, Linda; Komac, Marijana; Stegić, Oresta Makaruha; Munić, Vesna; Ralić, Jovica; Stanić, Barbara; Banjanac, Mihailo; Marković, Stribor; Hrvačić, Boška; Paljetak, Hana Čipčić;

Bioorganic & medicinal chemistry - 21

2012

Dibenzo [b, f] oxepin‐10 (11H)‐one and Dibenzo [b, f] thiepin‐10 (11H)‐one as Useful Synthons in the Synthesis of Various Dibenzo [e, h] azulenes

Pešić, Dijana; Landek, Ivana Ozimec; Rupčić, Renata; Modrić, Marina; Džapo, Iva; Trojko, Rudolf; Merćep, Mladen; Mesić, Milan;

Journal of heterocyclic chemistry - 49

2010

Novel tetracyclic imidazole derivatives: Synthesis, dynamic NMR study, and anti‐inflammatory evaluation

Rupčić, Renata; Modrić, Marina; Hutinec, Antun; Čikoš, Ana; Stanić, Barbara; Mesić, Milan; Pešić, Dijana; Merćep, Mladen;

Journal of heterocyclic chemistry - 47

2011

A conjugate of pyridine-4-aldoxime and atropine as a potential antidote against organophosphorus compounds poisoning.

Lovrić, Jasna; Berend, Suzana; Vrdoljak, Ana Lucić; Radić, Božica; Katalinić, Maja; Kovarik, Zrinka; Želježić, Davor; Kopjar, Nevenka; Rast, Slavko; Mesić, Milan;

Acta Biochimica Polonica - 58

2018

An alternative synthesis of the non-small cell lung carcinoma drug afatinib

Kovacevic, Tatjana; Mesic, Milan; Avdagic, Amir; Zegarac, Miroslav;

Tetrahedron letters - 59

2010

Novel spirotetracyclic zwitterionic dual H1/5-HT2A receptor antagonists for the treatment of sleep disorders

Gianotti, Massimo; Botta, Maurizio; Brough, Stephen; Carletti, Renzo; Castiglioni, Emiliano; Corti, Corrado; Dal-Cin, Michele; Delle Fratte, Sonia; Korajac, Denana; Lovric, Marija;

Journal of medicinal chemistry - 53

2012

Antimalarial activity of 9a-N substituted 15-membered azalides with improved in vitro and in vivo activity over azithromycin

Perić, Mihaela; Fajdetić, Andrea; Rupčić, Renata; Alihodžić, Sulejman; Žiher, Dinko; Bukvić Krajačić, Mirjana; Smith, Kirsten S; Ivezić-Schönfeld, Zrinka; Padovan, Jasna; Landek, Goran;

Journal of medicinal chemistry - 55

2025

Spotting the unforeseen in the preparation of N-(azetidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine derivatives

Brekalo, Iva; Istuk, Zorica Marusic; Mesic, Milan; Cicak, Marijo; Elenkov, Ivaylo J.; Cuzzolin, Alberto; Rancati, Fabio; Accetta, Alessandro;

Tetrahedron Letters - 155

2023

Chemical proteomics approach for detection of potential off-targets associated with the EGFRi erlotinib

Kovačević, Tatjana; Nujić, Krunoslav; Mesić, Milan;

Book of Abstracts

2023

Chemical proteomics approach for detection of potential off-targets associated with the EGFRi erlotinib

Kovačević, Tatjana; Nujić, Krunoslav; Mesić, Milan;

Book of Abstracts

2013

Conformational properties and chiral separation of dibenzo [b, f] thieno [3, 4-d]-fused oxepines and thiepines

Landek, Goran; Ozimec Landek, Ivana; Pešić, Dijana; Mesić, Milan; Šunjić, Vitomir;

Monatshefte für Chemie-Chemical Monthly - 144

Autorski indeks

Gabelica Marković, V; Mesić, M; AlihodŢić, S;

2023

Different chemical proteomic approaches to identify the targets of lapatinib

Kovačević, Tatjana; Nujić, Krunoslav; Cindrić, Mario; Dragojević, Snježana; Vinter, Adrijana; Hozić, Amela; Mesić, Milan;

Journal of Enzyme Inhibition and Medicinal Chemistry - 38

1994

Rearrangement of bicyclo [3.2. 0] heptyl precursors to the 7-norbornyl cation in the cryogenic SbF5 matrix

Mesić, Milan; Sunko, Dionis E; Vančik, Hrvoj;

Journal of the Chemical Society, Perkin Transactions 2

2011

Primjena znanstvenih rezultata u proizvodnji Kemija u tvrtki Galapagos istraživački centar doo

Gabelica Marković, V; Mesić, M; Alihodžić, S; Kovačević, K;

Kemija u industriji: Časopis kemičara i kemijskih inženjera Hrvatske - 60

Modifikacije 1-tiadibenzo [e, h] azulena u položaju 8: sinteza i protuupalno djelovanje

Ozimec Landek, Ivana; Mesić, Milan; Pešić, Dijana; Stanić, Barbara; Hrvačić, Boška; Merćep, Mladen;

2010

LANDEK IO* 1, PEŠIĆ D. 1, TROJKO R. 1, 2, BOGDANOVIĆ MD 1, 3

MERĆEP, M; MESIĆ, M;

HETEROCYCLES - 81

1998

C–H Hyperconjugation in α-chlorocarbocations

Mesić, Milan; Novak, Igor; Sunko, Dionis E; Vančik, Hrvoj;

Journal of the Chemical Society, Perkin Transactions 2

1998

Lyotropic Liquid Crystalline Phases from Symmetric Double-Tailed Surfactants: Sodium 1′-(6)-Undecylbenzenesulfonate, 1′-(7)-Tridecylbenzenesulfonate, and 1′-(8)-Pentadecylbenzenesulfonate in Water

Jalšenjak, Nenad; Mesić, Milan; Mihalić, Zlatko; Pavešić, Nasta; Pracaić, Suzana; Težak, Đurđica; Platz, Gerhard; Peukert, Susane; Ulbricht, Werner; Danino, Dganit;

Journal of colloid and interface science - 208

2006

Applicability of an ultrasonic nebulization system for the airways delivery of beclomethasone dipropionate in a murine model of asthma

Hrvačić, Boška; Bošnjak, Berislav; Tudja, Marijan; Mesić, Milan; Merćep, Mladen;

Pharmaceutical research - 23

1991

Reactivations of acetylcholinesterase inhibited by organophosphorus compounds. Imidazole derivatives. II

Mesić, M; Deljac, A; Deljac, V; Binenfeld, Z; Kilibarda, V; Maksimović, M; Kovačević, V;

Acta Pharm. Jugosl - 41

Opis wynalazku

Rupčić, M Modrić; Hutinec, A; Čikoš, A; Stanić, B; Mesić, M; Pešić, D; Merćep, M; Heterocycl, J;

2008

Measurement of malondialdehyde (MDA) level in rat plasma after simvastatin treatment using two different analytical methods

Lovrić, Jasna; Mesić, Milan; Macan, Marija; Koprivanac, Marijan; Kelava, Marta; Bradamante, Vlasta;

Periodicum biologorum - 110

2011

Synthesis and anti‐inflammatory activity of 8H‐1‐thia‐8‐aza‐dibenzo [e, h] azulenes

Ozimec Landek, Ivana; Pešić, Dijana; Merćep, Mladen; Stanić, Barbara; Mesić, Milan;

Journal of Heterocyclic Chemistry - 48

2011

Applying Research Results to Production Chemistry in the Galapagos Research Center Ltd., Zagreb

Gabelica Marković, V; Mesić, M; Alihodžić, S; Kovačević, K;

Kemija u industriji: Časopis kemičara i kemijskih inženjera Hrvatske - 60

1994

Reactivators of acetylcholinesterase inhibited by organophosphorus compounds. Imidazole derivatives

Mesić, M; Rončević, R; Radić, B; Fajdetić, A; Binenfeld, Z;

Acta Pharm - 44

2007

Synthesis of 2‐formyl‐1‐aza‐dibenzo [e, h] azulenes

Pešić, Dijana; Landek, Ivana Ozimec; Čikoš, Ana; Metelko, Biserka; Gabelica, Vesna; Stanić, Barbara; Merćep, Mladen; Mesić, Milan;

Journal of Heterocyclic Chemistry - 44

2D versus 3D cell culture platforms for screening antitumoral activity of novel chemical entities

Trzun, M; Paravić Radičević, A; Frka Borić, K; Jelić, D; Vujasinović, I; Mesić, M; Eraković Haber, V; Brajša, K;

2013

Synthesis and anti-inflammatory activity of novel furochromenes

Elenkov, Ivaylo Jivkov; Hrvačić, Boška; Marković, Stribor; Mesić, Milan; Čempuh Klonkay, Andreja; Lerman, Lidija; Filipović Sučić, Anita; Vujasinović, Ines; Bošnjak, Berislav; Brajša, Karmen;

Croatica Chemica Acta - 86

1996

Effects of Structure on the Reactivity of α-Hydroxydialkylnitrosamines in Aqueous Solutions1

Mesić, Milan; Revis, Cynthia; Fishbein, James C;

Journal of the American Chemical Society - 118

Differences in anticancer drug sensitivities in 3D and 2D cancer cell culture systems: model on ADAM10 novel anticancer drug target and biomarker

Trzun, M; Paravić Radičević, A; Frka Borić, K; Jelić, D; Vujasinović, I; Mesić, M; Eraković Haber, V; Brajša, K;

2018

Methods for arylethylation of amines and heteroarenes

Manallack, D; Prankerd, R; Yuriev, E; Oprea, T; Chalmers, D; Dong, H; Latka, R; Driver, T; Wekesa, F; Phadke, N;

SynOpen - 2

2001

Chemoenzymatic synthesis of all four cytoxazone stereoisomers

Hameršak, Zdenko; Ljubović, Edina; Merćep, Mladen; Mesić, Milan; Šunjić, Vitomir;

Synthesis - 2001

1997

Antidotal efficacy of quinuclidinium oximes against soman poisoning

Lucić, A; Radić, B; Peraica, M; Mesić, M; Primožič, I; Binenfeld, Z;

Archives of toxicology - 71

2006

Volatile constituents from flowers, leaves, bark and wood of Prunus mahaleb L.

Mastelić, Josip; Jerković, Igor; Mesić, Milan;

Flavour and fragrance journal - 21

2011

Determination of aqueous stability and degradation products of series of coumarin dimers

Dragojević, Snježana; Šunjić, Vitomir; Bencetić-Mihaljević, Vlatka; Ralić, Jovica; Mesić, Milan; Elenkov, Ivaylo Jivkov; Sučić, Anita Filipović; Klonkay, Andreja Čempuh; Lerman, Lidija; Ilijaš, Marina;

Journal of pharmaceutical and biomedical analysis - 54

1996

Failure to isolate the first N-nitrosiminium cation

Chahoua, Latifa; Mesić, Milan; Fishbein, James C;

The Journal of Organic Chemistry - 61

2019

Benzoxaboroles—Novel autotaxin inhibitors

Kraljić, Kristina; Jelić, Dubravko; Žiher, Dinko; Cvrtila, Adam; Dragojević, Snježana; Sinković, Verona; Mesić, Milan;

Molecules - 24

2013

Macrolactonolides: a novel class of anti-inflammatory compounds

Tomašković, Linda; Komac, Marijana; Stegić, Oresta Makaruha; Munić, Vesna; Ralić, Jovica; Stanić, Barbara; Banjanac, Mihailo; Marković, Stribor; Hrvačić, Boška; Paljetak, Hana Čipčić;

Bioorganic & medicinal chemistry - 21

2012

Dibenzo [b, f] oxepin‐10 (11H)‐one and Dibenzo [b, f] thiepin‐10 (11H)‐one as Useful Synthons in the Synthesis of Various Dibenzo [e, h] azulenes

Pešić, Dijana; Landek, Ivana Ozimec; Rupčić, Renata; Modrić, Marina; Džapo, Iva; Trojko, Rudolf; Merćep, Mladen; Mesić, Milan;

Journal of Heterocyclic Chemistry - 49

1993

Die Struktur des 7‐Norbornyl‐Kations und seine Umlagerung in das 2‐Norbornyl‐Kation

Sieber, Stefan; Schleyer, Paul von Ragné; Vančik, Hrvoj; Mesić, Milan; Sunko, Dionis E;

Angewandte Chemie - 105

2010

Novel tetracyclic imidazole derivatives: Synthesis, dynamic NMR study, and anti‐inflammatory evaluation

Rupčić, Renata; Modrić, Marina; Hutinec, Antun; Čikoš, Ana; Stanić, Barbara; Mesić, Milan; Pešić, Dijana; Merćep, Mladen;

Journal of Heterocyclic Chemistry - 47

2011

A conjugate of pyridine-4-aldoxime and atropine as a potential antidote against organophosphorus compounds poisoning.

Lovrić, Jasna; Berend, Suzana; Vrdoljak, Ana Lucić; Radić, Božica; Katalinić, Maja; Kovarik, Zrinka; Želježić, Davor; Kopjar, Nevenka; Rast, Slavko; Mesić, Milan;

Acta Biochimica Polonica - 58

1993

The Nature of the 7‐Norbornyl Cation and its Rearrangement into the 2‐Norbornyl Cation

Sieber, Stefan; von Ragué Schleyer, Paul; Vančik, Hrvoj; Mesić, Milan; Sunko, Dionis E;

Angewandte Chemie International Edition in English - 32

2000

Mechanisms of decomposition of α-hydroxydialkylnitrosamines in aqueous solution

Milan Mesic’,; Peuralahti, Jari; Blans, Patrick; Fishbein, James C;

Chemical Research in Toxicology - 13

2010

Synthesis of naphtho [2, 3-b]-and naphtho [1, 2-b]-fused thieno [2, 3-d][1] benzoxepins and thieno [2, 3-d][1] benzothiepins

Landek, Ivana Ozimec; Pesic, Dijana; Trojko, Rudolf; Bogdanovic, Maja Devcic; Mercep, Mladen; Mesic, Milan;

Heterocycles - 81

2018

An alternative synthesis of the non-small cell lung carcinoma drug afatinib

Kovacevic, Tatjana; Mesic, Milan; Avdagic, Amir; Zegarac, Miroslav;

Tetrahedron Letters - 59

2006

Synthesis of 1, 8‐Dioxa‐dibenzo [e, h] azulenes.

Pesic, Dijana; Landek, Ivana Ozimec; Mercep, Mladen; Mesic, Milan;

ChemInform - 37

1996

Imidazolium and quinuclidinium oximes as antidotes in soman poisoning

Lucić, Ana; Radić, Božica; Primožič, Ines; Rončevič, Renata; Mesić, Milan;

Toxicology Letters

2010

Novel spirotetracyclic zwitterionic dual H1/5-HT2A receptor antagonists for the treatment of sleep disorders

Gianotti, Massimo; Botta, Maurizio; Brough, Stephen; Carletti, Renzo; Castiglioni, Emiliano; Corti, Corrado; Dal-Cin, Michele; Delle Fratte, Sonia; Korajac, Denana; Lovric, Marija;

Journal of medicinal chemistry - 53

1997

Evidence for the Formation of α-Hydroxydialkylnitrosamines in the pH-Independent Solvolysis of α-(Acyloxy) dialkylnitrosamines

Chahoua, Latifa; Mesic, Milan; Revis, Cynthia L; Vigroux, Alain; Fishbein, James C;

The Journal of Organic Chemistry - 62

2006

Synthesis Of 1, 8‐dioxa‐dibenzo [e, h] azulenese

Pešić, Dijana; Landek, Ivana Ozimec; Merćaep, Mladen; Mesića, Milan;

Journal of Heterocyclic Chemistry - 43

2012

Antimalarial activity of 9a-N substituted 15-membered azalides with improved in vitro and in vivo activity over azithromycin

Perić, Mihaela; Fajdetić, Andrea; Rupčić, Renata; Alihodžić, Sulejman; Žiher, Dinko; Bukvić Krajačić, Mirjana; Smith, Kirsten S; Ivezić-Schönfeld, Zrinka; Padovan, Jasna; Landek, Goran;

Journal of medicinal chemistry - 55

2009

2, 8-Dithia-dibenzo [e, h] azulenes and their 8-oxa analogs. synthesis and anti-inflammatory activity

Landek, Ivana Ozimec; Pešic, Dijana; Novak, Predrag; Stanic, Barbara; Nujic, Krunoslav; Mercep, Mladen; Mesic, Milan;

Heterocycles - 78

2010

Bogdanović, 2 Mladen Merćep, 3 and Milan Mesić

Landek, Ivana Ozimec; Pešić, Dijana; Trojko, Rudolf; Devčić, Maja;

HETEROCYCLES - 81

2010

LANDEK IO* 1, PEŠIĆ D. 1, TROJKO R. 1, 2, BOGDANOVIĆ MD 1, 3

MERĆEP, M; MESIĆ, M;

HETEROCYCLES - 81

Modifikacije 1-tiadibenzo [e, h] azulena u položaju 8: sinteza i protuupalno djelovanje

Ozimec Landek, Ivana; Mesić, Milan; Pešić, Dijana; Stanić, Barbara; Hrvačić, Boška; Merćep, Mladen;

2011

Primjena znanstvenih rezultata u proizvodnji Kemija u tvrtki Galapagos istraživački centar doo

Gabelica Marković, V; Mesić, M; Alihodžić, S; Kovačević, K;

Kemija u industriji: Časopis kemičara i kemijskih inženjera Hrvatske - 60

1994

Rearrangement of bicyclo [3.2. 0] heptyl precursors to the 7-norbornyl cation in the cryogenic SbF5 matrix

Mesić, Milan; Sunko, Dionis E; Vančik, Hrvoj;

Journal of the Chemical Society, Perkin Transactions 2

2023

Different chemical proteomic approaches to identify the targets of lapatinib

Kovačević, Tatjana; Nujić, Krunoslav; Cindrić, Mario; Dragojević, Snježana; Vinter, Adrijana; Hozić, Amela; Mesić, Milan;

Journal of Enzyme Inhibition and Medicinal Chemistry - 38

Autorski indeks

Gabelica Marković, V; Mesić, M; AlihodŢić, S;

2013

Conformational properties and chiral separation of dibenzo [b, f] thieno [3, 4-d]-fused oxepines and thiepines

Landek, Goran; Ozimec Landek, Ivana; Pešić, Dijana; Mesić, Milan; Šunjić, Vitomir;

Monatshefte für Chemie-Chemical Monthly - 144

2023

Chemical proteomics approach for detection of potential off-targets associated with the EGFRi erlotinib

Kovačević, Tatjana; Nujić, Krunoslav; Mesić, Milan;

Book of Abstracts

2013. - 2019.

Kemijska proteomika u istraživanju lijekova - selektivnost lijeka prema biološkoj meti

Tatjana Kovačević Doktorat

Medicinska kemija

Fidelta

Datum obrane: 17.07.2019.

2013. - 2019.

Novi benzoksaborolni inhibitori autotaksina kao potencijalni antitumorski lijekovi

Kristina Kraljić Doktorat

Medicinska kemija

Fidelta

Datum obrane: 13.12.2019.

14.03.2024.

Preparation of heterocyclic derivatives as Janus kinase inhibitors for treatment of respiratory diseases, WO2024052512

Accetta, Alessandro; Cuzzolin, Alberto; Rancati, Fabio; Rizzi, Andrea; Elenkov, Ivaylo Jivkov; Mesic, Milan; Radosevic, Ela

heterocyclic derivative preparation janus kinase inhibitor inflammatory respiratory disease; pyrazolopyrimidine preparation janus kinase inhibitor combination therapy asthma COPD

14.03.2024.

Heterocyclic derivatives as JANUS kinase inhibitors, WO2024052513

Accetta, Alessandro; Cuzzolin, Alberto; Rancati, Fabio; Rizzi, Andrea; Elenkov, Ivaylo Jivkov; Mesic, Milan; Fiorelli, Claudio

JAK tyrosine protein kinases (JAK1, JAK2, JAK3, and TYK2), compounds, asthma, COPD and other respiratory diseases, therapy

22.09.2022.

Preparation of heterocyclic derivatives as janus kinase inhibitors for treatment of respiratory diseases; WO2022194782

Accetta, Alessandro; Rancati, Fabio; Rizzi, Andrea; Ziher, Dinko; Mesic, Milan; Elenkov, Ivaylo

heterocyclic derivative preparation inflammatory respiratory disease; janus kinase inhibitor combination therapy asthma COPD

22.09.2022.

Preparation of heterocyclic derivatives as janus kinase inhibitors for treatment of respiratory diseases; WO2022194781

Accetta, Alessandro; Rancati, Fabio; Rizzi, Andrea; Cuzzolin, Alberto; Mesic, Milan; Ziher, Dinko; Elenkov, Ivaylo; Butkovic, Kristina

heterocyclic derivative preparation inflammatory respiratory disease; janus kinase inhibitor combination therapy asthma COPD

22.09.2022.

Preparation of heterocyclic derivatives as janus kinase inhibitors for treatment of respiratory diseases; WO2022194779

Accetta, Alessandro; Rancati, Fabio; Rizzi, Andrea; Cuzzolin, Alberto; Mesic, Milan; Zadravec, Rahela; Ziher, Dinko; Elenkov, Ivaylo

heterocyclic derivative preparation inflammatory respiratory disease; janus kinase inhibitor combination therapy asthma COPD

25.02.2021.

Preparation of fused pyrimidine compounds as autotaxin inhibitors and their pharmaceutical compositions for the treatment of fibrotic diseases WO2021032323

Temal-Laib, Taoues; Heckmann, Bertrand; Couty, Sylvain; Richard, Sebastien; Annoot, Denis Maurice; Tirera, Amynata; Mesic, Milan; Triballeau, Nicolas

fused pyrimidine preparation autotaxin inhibitor fibrosis; pyridopyrimidine pyrrolopyrimidine pyrimidoazepine preparation ENPP2 inhibitor inflammatory fibrosis pain

24.02.2021.

Preparation of fused pyrimidine compounds as autotaxin inhibitors and their pharmaceutical compositions for the treatment of fibrotic diseases EP3782997

Temal-Laib, Taoues; Heckmann, Bertrand; Couty, Sylvain; Richard, Sebastien; Annoot, Denis Maurice; Tirera, Amynata; Triballeau, Nicolas; Mesic, Milan

fused pyrimidine preparation autotaxin inhibitor fibrosis; pyridopyrimidine pyrrolopyrimidine pyrimidoazepine preparation ENPP2 inhibitor inflammatory fibrosis pain

17.01.2019.

Preparation of pyrrolopyrimidine and pyrrolopyridine derivatives as ASK1 inhibitors; WO2019012284

Amantini, David; Mesic, Milan; Saxty, Gordon; Poljak, Tanja; Vujasinovic, Ines; Ziher, Dinko; Witty, David; Gibson, Karl Richard

pyrrolopyrimidine pyrrolopyridine derivative preparation ASK1 inhibitor pain fibrotic disease

16.09.2017.

Preparation of seco macrolide aminoglycosides for use in the treatment of prophylaxis

Fajdetic, Andrea; Matanovic Skugor, Maja; Elenkov, Ivaylo; Kragol, Goran; Bukvic, Mirjana; Marusic Istuk, Zorica; Kostrun, Sanja; Ziher, Dinko; Rupcic, Renata; Butkovic, Kristina; Duksi, Marko; Ozimec Landek, Ivana; Pesic, Dijana; Hutinec, Antun; Mesic, Milan; Saxty, Gordon; Poljak, Visnja

amino acid preparation erythromycin azithromycin aminoglycoside IL6; cyclization erythromycin azithromycin macrolide preparation inflammation prophylaxis autoimmune; erythromycin azithromycin macrolide ring opening preparation prophylaxis inflammation autoimmune

05.02.2009.

Spiro compounds useful as antagonists of the H1 receptor and their stereoselective preparation, pharmaceutical compositions and use in the treatment of sleep disorders; WO2009016084

Castiglioni, Emiliano; Di Fabio, Romano; Gianotti, Massimo; Mesic, Milan; Pavone, Francesca; Rast, Slavko; Stasi, Luigi Piero

spiro compound asym preparation H1 antagonist treatment sleep disorder

28.08.2007.

Preparation of 1- or 3-thia-benzonaphthoazulenes as inhibitors of tumor necrosis factor production and intermediates for the preparation thereof; US7262309 B2

Mercep, Mladen; Mesic, Milan; Pesic, Dijana; Ozimec, Ivana; Trojko, Rudolf

analgesic thiabenzonaphthoazulene preparation; thiabenzonaphthoazulene preparation inhibitor tumor necrosis factor production; interleukin 1 production inhibitor thiabenzonaphthoazulene preparation

23.08.2007.

Use of cell-specific macrolide-antiinflammatory molecule conjugates for treatment of inflammatory diseases of the gastrointestinal tract WO2007093840 A2

Mercep, Mladen; Mesic, Milan; Tomaskovic, Linda; Markovic, Stribor

macrolide antiinflammatory conjugate gastrointestinal inflammation treatment

26.10.2006.

Bis-(coumarin) compounds with antiinflammatory activity and their preparation, pharmaceutical compositions and use in the treatment of asthma and inflammatory diseases; WO2006111858, A2

Mercep, Mladen; Malnar, Ivica; Hrvacic, Boska; Markovic, Stribor; Filipovic Sucic, Anita; Bosnjak, Berislav; Cempuh Klonkay, Andreja; Rupcic, Renata; Hutinec, Antun; Elenkov, Ivaylo Jivkov; Mesic, Milan

biscoumarin preparation pharmaceutical composition antiinflammatory treatment asthma inflammatory disease; coumarin preparation pharmaceutical composition antiinflammatory treatment asthma inflammatory disease

19.10.2006.

Tetracyclic dibenzo[e,h]azulenes as monoamine reuptake inhibitors, their preparation, pharmaceutical compositions, and use for treatment of CNS diseases and disorders; WO2006109190, A1

Mesic, Milan; Mercep, Mladen; Pesic, Dijana; Rupcic, Renata; Stanic, Barbara

benzo azulene preparation monoamine reuptake inhibitor

08.09.2006.

Preparation of antiinflammatory conjugates of erythromycin macrolides and coumarins; WO2006092739, A1

Mercep, Mladen; Malnar, Ivica; Filipovic Sucic, Anita; Mesic, Milan

human antiinflammatory coumarin erythromycin macrolide amino glycoside preparation prodrug

17.08.2006.

Use of immune cell specific conjugates for treatment of inflammatory diseases of gastrointestinal tract; US20060183696, A1

Mercep, Mladen; Mesic, Milan; Tomaskovic, Linda; Markovic, Stribor

immune cell specific conjugate gastrointestinal tract inflammation treatment; antiinflammatory agent macrolide conjugate gastrointestinal inflammation treatment

20.07.2006.

Preparation of anti-inflammatory erythromycin macrolide conjugates; WO2006075255, A2

Mercep, Mladen; Mesic, Milan; Markovic, Stribor; Pesic, Dijana; Ozimec Landak, Ivana; Komac, Marijana; Makaruha Stegic, Oresta; Selmani, Selvira; Banjanac, Mihailo

TNF IL interleukin prostaglandin synthase inhibitor; erythromycin macrolide preparation antiinflamatory human analgesic arthritis osteoarthritis prodrug

04.05.2006.

Conjugates with anti-inflammatory activity; WO2006046123, A2

Mercep, Mladen; Mesic, Milan; Tomaskovic, Linda; Markovic, Stribor; Poljak, Visnja; Sijan, Gordana; Selmani, Selvira

macrolide steroid conjugate preparation antiinflammatory agent; steroid conjugate macrolide preparation antiinflammatory agent; NSAID conjugate macrolide preparation antiinflammatory agent; immune disorder treatment macrolide steroid conjugate preparation

16.02.2006.

Use of immune cell specific conjugates for treatment of inflammatory diseases of the gastrointestinal tract; US20060035845, A1

Mercep, Mladen; Mesic, Milan; Tomaskovic, Linda; Markovic, Stribor

immune cell specific conjugate gastrointestinal tract inflammation treatment

31.10.2005.

Method of preparation of [2-(11-chloro-8-oxa-1-thiadibenzo[e,h]azulen-2-yl-methoxy)-ethyl]-dimethylamine and salts thereof; HR2003000914 A2

Mercep, Mladen; Mesic, Milan; Modric, Marina; Rupcic, Renata; Simicic, Lidija; Trojko, Rudolf; Ozimec, Ivana; Pesic, Dijana; Klescic, Josip

thienodibenzoazulene compound salt preparation

13.10.2005.

Preparation of furochromene derivatives as anti-inflammatory agents; WO2005095411, A1

Mercep, Mladen; Mesic, Milan; Boska, Hrvacic; Ivaylo, Jivkov Elenkov; Ivica, Malnar

furochromene preparation inflammatory asthma human immune system treatment

11.08.2005.

Benzonaphthoazulenes for the manufacture of pharmaceutical formulations for the treatment and prevention of central nervous system diseases and disorders; WO2005072728, A1

Mercep, Mladen; Mesic, Milan; Pesic, Dijana; Ozimeclandek, Ivana; Trojko, Rudolf; Rupcic, Renata

azulene benzonaphthalene pharmaceutical central nervous system disease

02.07.2005.

Use of 1-oxadibenzo[e,h]azulenes for the manufacture of pharmaceutical formulations for the treatment and prevention of central nervous system diseases and disorders; WO2005049010, A1

Mercep, Mladen; Mesic, Milan; Pesic, Dijana

oxadibenzoazulene biogenic amine neurotransmitter central nervous system disease; dibenzoazulene oxa biogenic amine neurotransmitter CNS disease

02.07.2005.

1-Azadibenzo[e,h]azulene pharmaceuticals for the treatment of central nervous system diseases; WO2005049011, A1

Mercep, Mladen; Mesic, Milan; Pesic, Dijana

azadibenzoazulene pharmaceutical nervous system disease

02.07.2005.

1,2-Diazadibenzo[e,h]azulene pharmaceuticals for the treatment of central nervous system diseases; WO2005049015, A1

Mercep, Mladen; Mesic, Milan; Pesic, Dijana

diazadibenzoazulene pharmaceutical nervous system disease

02.07.2005.

1-Thia-3-azadibenzo[e,h]azulene pharmaceuticals for the treatment of central nervous system diseases; WO2005049020, A1

Mercep, Mladen; Mesic, Milan; Modric, Marina; Pesic, Dijana; Kidemet, Davor

thiadibenzoazulene pharmaceutical nervous system disease

02.07.2005.

Use of 3-aza-1-oxa-dibenzo[e,h]azulenes for the manufacture of pharmaceutical formulations for the treatment and prevention of central nervous system diseases and disorders; WO2005049036, A1

Mercep, Mladen; Mesic, Milan; Pesic, Dijana; Dzapo, Iva

azaoxadibenzoazulene biogenic amine neurotransmitter nervous system disease; dibenzoazulene azaoxa biogenic amine neurotransmitter CNS disease

02.07.2005.

Preparation of 1-aza-2-oxa-dibenzo[e,h]azulenes and their use for the manufacture of pharmaceutical formulations for the treatment and prevention of central nervous system diseases and disorders; WO2005049623, A1

Mercep, Mladen; Mesic, Milan; Pesic, Dijana; Dzapo, Iva

oxathiaazadibenzoazulene preparation treatment prevention central nervous system disease disorder; azaoxadibenzoazulene preparation treatment prevention central nervous system disease disorder; neurochem equilibrium disorder biogenic amine neurotransmitter treatment azaoxadibenzoazulene preparation

02.06.2005.

1,3-Diazadibenzo[e,h]azulene pharmaceutical for the treatment of central nervous system diseases ;WO2005049016, A1

Mercep, Mladen; Mesic, Milan; Rupcic, Renata; Pesic, Dijana

diazadibenzoazulene pharmaceutical nervous system disease

12.05.2005.

Use of 2-thiadibenzo[e,h]azulenes for the manufacture of pharmaceutical formulations for the treatment and prevention of central nervous system diseases and disorders; WO2005041856, A2

Mercep, Mladen; Mesic, Milan; Pesic, Dijana; Ozimec Landek, Ivana; Hrvacic, Boska; Stanic, Barbara

biogenic amine neurotransmitter central nervous system drug thiadibenzoazulene

03.02.2005.

Preparation of substituted furochromene compounds with antiinflammatory activity; WO2005010006, A1

Mercep, Mladen; Mesic, Milan; Hrvacic, Boska; Elenkov, Ivaylo Jivkov; Malnar, Ivica; Markovic, Stribor; Simicic, Lidija; Cempuh Klonkay, Andreja; Filipovic, Anita

furochromene compound preparation antiinflammatory; furochromenone dihydro chromenyl preparation antiinflammatory; dihydrofurochromenone chromenyl derivative preparation antiinflammatory

03.02.2005.

Preparation of substituted furochromenes with antiinflammatory activity; WO2005010007, A1

Mercep, Mladen; Mesic, Milan; Hrvacic, Boska; Elenkov, Ivaylo Jivkov; Malnar, Ivica; Markovic, Stribor; Simicic, Lidija; Cempuh Klonkay, Andreja; Filipovic, Anita

furochromene substituted preparation antiinflammatory; furochromeneone chromenyl preparation antiinflammatory

16.09.2004.

Preparation of thiadibenzoazulene derivatives as inhibitors of TNF-α and IL-1 production for the treatment of inflammatory diseases; WO2004078763, A1

Mercep, Mladen; Mesic, Milan; Pesic, Dijana; Benko, Iva

thiadibenzoazulene preparation TNF IL1 production inhibitor antiinflammatory

04.09.2004.

35. Preparation of macrolide-conjugates with anti-inflammatory activity; WO2004094449, A1

Mercep, Mladen; Mesic, Milan; Tomaskovic, Linda; Markovic, Stribor; Hrvacic, Boska; Makaruha, Oresta; Poljak, Visnja

macrolide conjugate preparation antiinflammatory; steroid macrolide conjugate preparation antiinflammatory; nonsteroid macrolide conjugate preparation antiinflammatory

15.01.2004.

Preparation of non-steroidal macrolide erythromycin analog glycosides for treatment of inflammatory diseases; WO2004005309, A2

Mercep, Mladen; Mesic, Milan; Tomaskovic, Linda; Markovic, Stribor

interleukin cytokine steroid macrolide glycoside human preparation antiinflammatory prodrug; macrolide glycoside human erythromycin preparation antiinflammatory receptor enzyme inhibitor

15.01.2004.

Preparation of steroid-containing macrolide erythromycin analog glycosides for treatment of inflammatory diseases; WO2004005310, A2

Mercep, Mladen; Mesic, Milan; Tomaskovic, Linda; Markovic, Stribor; Makaruha, Oresta; Poljak, Visnja

interleukin cytokine steroid macrolide glycoside human preparation antiinflammatory prodrug; steroid macrolide glycoside human erythromycin preparation antiinflammatory glucocorticosteroid receptor

15.01.2004.

Preparation of steroid-containing macrolide glycopeptides as carriers for steroid/non-steroid anti-inflammatory, antineoplastic, and antiviral active molecules; WO2004005313, A2

Mercep, Mladen; Mesic, Milan; Tomaskovic, Linda; Markovic, Stribor

prodrug steroid macrolide glycoside glycopeptide preparation antineoplastic antiviral antiinflammatory; steroid macrolide glycoside glycopeptide preparation antineoplastic antiviral antiinflammatory human

04.12.2003.

Preparation of 1,2-Diazadibenzoazulenes as tumor necrosis factor inhibitors; WO2003099822, A2

Mercep, Mladen; Mesic, Milan; Pesic, Dijana

diaza dibenzoazulene derivative preparation tumor necrosis factor

04.12.2003.

Preparation of 1,3-diazadibenzoazulene imidazole derivatives as tumor necrosis factor inhibitors; WO2003099823, A2

Mercep, Mladen; Mesic, Milan; Rupcic, Renata; Pesic, Dijana

diaza dibenzoazulene imidazole derivative preparation tumor necrosis factor inhibitor

04.12.2003.

1-Thia-3-aza-dibenzoazulene thiazole derivatives as inhibitors of tumor necrosis factor production and intermediates for the preparation thereof; WO2003099827, A1

Mercep, Mladen; Mesic, Milan; Modric, Marina; Pesic, Dijana; Kidemet, Davor

thiazole dibenzoazulene derivative preparation tumor necrosis factor inhibitor

27.11.2003.

Preparation of 1-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the preparation thereof; WO2003097648, A1

Mercep, Mladen; Mesic, Milan; Pesic, Dijana

azadibenzoazulene preparation antiinflammatory analgesic TNFalpha IL1 production inhibitor; tumor necrosis factor alpha production azadibenzoazulene preparation; interleukin IL1 production inhibitor azadibenzoazulene preparation

27.11.2003.

Preparation of 1-oxa-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the preparation thereof; WO2003097649, A2

Mercep, Mladen; Mesic, Milan; Pesic, Dijana

oxadibenzoazulene preparation antiinflammatory analgesic TNFalpha IL1 production inhibitor; tumor necrosis factor alpha production oxadibenzoazulene preparation; interleukin IL1 production inhibitor oxadibenzoazulene preparation; dibenzoazulene oxa preparation antiinflammatory analgesic TNFalpha IL1 production inhibitor

16.10.2003.

Preparation of 1- or 3-thienonaphthazulenes as inhibitors of tumor necrosis factor production; WO2003084961, A1

Mercep, Mladen; Mesic, Milan; Pesic, Dijana; Ozimec, Ivana; Trojko, Rudolf

thienonaphthazulene preparation antiinflammatory TNF interleukin inhibitor analgesic

16.10.2003.

Preparation of 2-thiadibenzoazulenes and related compounds as inhibitors of tumor necrosis factor production; WO2003084962, A1

Mercep, Mladen; Mesic, Milan; Pesic, Dijana; Ozimec, Ivana

thiadibenzoazulene preparation tumor necrosis factor inhibitor; cytokine inflammation mediator production inhibitor thiadibenzoazulene dithiadibenzoazulene oxathiadibenzoazulene preparation

16.10.2003.

Preparation of 1-oxa-3-azadibenzoazulenes as inhibitors of tumor necrosis factor production; WO2003084964, A1

Mercep, Mladen; Mesic, Milan; Pesic, Dijana; Benko, Iva

oxaazadibenzoazulene preparation tumor necrosis factor production inhibitor; oxathiaazadibenzoazulene dioxaazadibenzoazulene preparation antiinflammatory; cytokine production inhibitor oxaazadibenzoazulene preparation

14.08.2003.

Thienodibenzoazulene compounds as tumor necrosis factor inhibitors and their preparation, pharmaceutical compositions and use in the treatment of inflammation; US20030153750, A1

Mercep, Mladen; Mesic, Milan; Pesic, Dijana; Zupanovic, Zeljko; Hrvacic, Boska

thienodibenzoazulene compound preparation TNF inhibitor treatment inflammation

18.07.2002.

Preparation of conjugates of immune cell specific macrolide compounds with anti-inflammatory compounds for improved cellular targeting of anti-inflammatory therapy; WO2002055531, A1

Mercep, Mlanden; Mesic, Milan; Tomaskovic, Linda; Komac, Marijana; Hrvacic, Boska; Markovic, Stribor

macrolide steroid conjugate preparation antiinflammatory agent; androstane homoerythromycin conjugate preparation antiinflammatory agent; immune cell specific antiinflammatory macrolide preparation; glucocorticoid receptor binding macrolide steroid conjugate preparation; azithromycin steroid conjugate preparation antiinflammatory agent; erythromycin steroid conjugate preparation antiinflammatory agent

22.11.2001.

Preparation of thienodibenzoazulene compounds as inhibitors of tumor necrosis factor and interleukin production; WO2001087890, A1

Mercep, Mladen; Mesic, Milan; Pesic, Dijana; Zupanovic, Zeljko; Hrvacic, Boska

TNF interleukin production inhibitor thienodibenzoazulene preparation; thienodibenzoazulene preparation inhibitor tumor necrosis factor; antiinflammatory analgesic thienodibenzoazulene preparation

31.08.1994.

Process for the dechlorination of polychlorinated biphenyls; HR9300197 A2

Frobe, Zlatko; Suste, Andreja; Mesic, Milan

dehalogenation polyhalogenated bisphenol cetyltrimethylammonium bromide zinc

PORTFELJ / prof. dr. sc Milan Mesić

Portfelj

Obrazovanje

Radno iskustvo

Nastavna djelatnost

Kolegiji

Znanstvena djelatnost

Znanstveni radovi

Mentorstvo doktorandima

Patenti

Administrativna djelatnost

Rukovođenje u državnoj upravi

Projekti