01.04.2008. - 17.09.2012.

Doktor kemije (PhD in Chemistry)

Doktorski studij

Sveučilište u Lajpcigu, Fakultet Mineralogije i kemije, Leipzig, Germany

01.02.2004. - 16.03.2006.

Magister po kemiju

Master of Sciences (MSc) in Chemistry

Sveučilište "Sv. Kiril i Metodij", Prirodno-matematički fakultet, Institut za kemiju, Skopje, Makedonija

01.03.2023. -

Docent

Sveučilište u Rijeci, Fakultet Biotehnologije i razvoja lijekova

01.02.2019. - 28.02.2023.

Senior Researcher

Universitat Pompeu Fabra, Department of Medicine and Life Sciences, Barcelona, Spain

12.11.2012. - 30.06.2018.

Posljedoktorand (Postdoc)

Institute for Research in Biomedicine, IRB Barcelona

12.11.2012.

Marie Curie COFUND Fellowship za posljediplomske studije

08.11.2011.

A. T. Kearney Scholarship awarded to participate at Falling Walls Lab 2011 in Berlin

28.06.2009.

Lindau Nobel Laureates Meeting scholarship awarded to participate at the prestigious 59th Meeting of Nobel Laureates in Lindau, dedicated to chemistry.

01.09.2007.

DAAD stipendija za doktorske studije na Sveučilište u Lajpcigu

01.08.2018.

Član IRB Barcelona alumni network

01.06.2016.

Član The European peptide Society

01.12.2014.

Član Marie Curie Alumni Association

01.04.2014. - 01.04.2015.

Član Société de Chimie Thérapeutique

01.01.2011.

Član DAAD alumni network

01.03.2023.

Uvod u Bioanorgansku kemiju

Prijediplomski sveučilišni studij "Biotehnologija i istraživanje lijekova"

Odjel za Biotehnologiju

Nositelj kolegija

2023

Antiviral Peptide-Based Conjugates: State of the Art and Future Perspectives

Todorovski, Toni; Kalafatovic, Daniela; Andreu, David;

Pharmaceutics - 15

2019

Algorithm-supported, mass and sequence diversity-oriented random peptide library design

Kalafatovic, Daniela; Mauša, Goran; Todorovski, Toni; Giralt, Ernest;

Journal of cheminformatics - 11

2023

How Do Cancer-Related Mutations Affect the Oligomerisation State of the p53 Tetramerisation Domain?

Nicolini, Federica; Todorovski, Toni; Puig, Eduard; Díaz-Lobo, Mireia; Vilaseca, Marta; García, Jesús; Andreu, David; Giralt, Ernest;

Current Issues in Molecular Biology - 45

2022

Targeting Zika Virus with New Brain-and Placenta-Crossing Peptide–Porphyrin Conjugates

Todorovski, Toni; Mendonça, Diogo A; Fernandes-Siqueira, Lorena O; Cruz-Oliveira, Christine; Guida, Giuseppina; Valle, Javier; Cavaco, Marco; Limas, Fernanda IV; Neves, Vera; Cadima-Couto, Íris;

Pharmaceutics - 14

2021

Penetrating the blood-brain barrier with new peptide–porphyrin conjugates having anti-HIV activity

Mendonça, Diogo A; Bakker, Mariët; Cruz-Oliveira, Christine; Neves, Vera; Jiménez, Maria Angeles; Defaus, Sira; Cavaco, Marco; Veiga, Ana Salomé; Cadima-Couto, Iris; Castanho, Miguel ARB;

Bioconjugate Chemistry - 32

2021

Structure-based design of a Cortistatin analogue with immunomodulatory activity in models of inflammatory bowel disease

Rol, Álvaro; Todorovski, Toni; Martin-Malpartida, Pau; Escolà, Anna; Gonzalez-Rey, Elena; Aragón, Eric; Verdaguer, Xavier; Vallès-Miret, Mariona; Farrera-Sinfreu, Josep; Puig, Eduard;

Nature Communications - 12

2010

Quantitative evaluation of tryptophan oxidation in actin and troponin I from skeletal muscles using a rat model of acute oxidative stress

Fedorova, Maria; Todorovsky, Toni; Kuleva, Nadezda; Hoffmann, Ralf;

Proteomics - 10

2019

Enfuvirtide-protoporphyrin IX dual-loaded liposomes: in vitro evidence of synergy against HIV-1 entry into cells

Figueira, Tiago N; Domingues, Marco M; Illien, Françoise; Cadima-Couto, Iris; Todorovski, Toni; Andreu, David; Sagan, Sandrine; Castanho, Miguel ARB; Walrant, Astrid; Veiga, Ana Salomé;

ACS Infectious Diseases - 6

2014

Folding kinetics of WW domains with the united residue force field for bridging microscopic motions and experimental measurements

Zhou, Rui; Maisuradze, Gia G; Suñol, David; Todorovski, Toni; Macias, Maria J; Xiao, Yi; Scheraga, Harold A; Czaplewski, Cezary; Liwo, Adam;

Proceedings of the National Academy of Sciences - 111

2012

Identification of isomeric 5‐hydroxytryptophan‐and oxindolylalanine‐containing peptides by mass spectrometry

Todorovski, Toni; Fedorova, Maria; Hoffmann, Ralf;

Journal of mass spectrometry - 47

2011

Mass spectrometric characterization of peptides containing different oxidized tryptophan residues

Todorovski, Toni; Fedorova, Maria; Hoffmann, Ralf;

Journal of mass spectrometry - 46

2015

Electrochromic thin films of sodium intercalated vanadium (V) oxide xerogels: Chemical bath deposition and characterization

Najdoski, Metodija; Koleva, Violeta; Stojkovikj, Sasho; Todorovski, Toni;

Surface and Coatings Technology - 277

2007

Molybdenum oxide thin solid films prepared with a new chemical bath deposition method

Todorovski, T; Najdoski, M; Velevska, Julijana;

Physica Macedonica, 56, 57–62 (2007). - 56

2007

A simple method for chemical bath deposition of electrochromic tungsten oxide films

Najdoski, Metodija Z; Todorovski, Toni;

Materials chemistry and physics - 104

2016

On the autofluorescence of aged fingermarks

van Dam, Annemieke; Aalders, Maurice CG; Todorovski, Toni; van Leeuwen, Ton G; Lambrechts, Saskia AG;

Forensic science international - 258

2016

Peptide aromatic interactions modulated by fluorinated residues: Synthesis, structure and biological activity of Somatostatin analogs containing 3-(3′, 5′ difluorophenyl)-alanine

Martín-Gago, Pablo; Rol, Álvaro; Todorovski, Toni; Aragón, Eric; Martin-Malpartida, Pau; Verdaguer, Xavier; Valles Miret, Mariona; Fernández-Carneado, Jimena; Ponsati, Berta; Macias, Maria J;

Scientific Reports - 6

2015

Addition of HOBt improves the conversion of thioester‐Amine chemical ligation

Todorovski, Toni; Suñol, David; Riera, Antoni; Macias, Maria J;

Peptide Science - 104

2007

The solution growth route and characterization of electrochromic tungsten oxide thin films

Todorovski, Toni; Najdoski, Metodija;

Materials Research Bulletin - 42

2011

Synthesis of peptides containing 5‐hydroxytryptophan, oxindolylalanine, N‐formylkynurenine and kynurenine

Todorovski, Toni; Fedorova, Maria; Hennig, Lothar; Hoffmann, Ralf;

Journal of Peptide Science - 17

2006

Chemical deposition of molybdenum oxide thin films from dimethyl sulfate bath

Todorovski, Toni; Najdoski, Metodija; Velevska, Julijana;

International Journal of Pure and Applied Chemistry, 1 (4), 549–552 (2006)

20.09.2024.

Analysis and characterization of bioactive peptides and peptide-drug conjugates by various tandem mass spectrometry (MS/MS) techniques

Toni Todorovski*, Izabela Škamo, Ralf Hoffmann, Daniela Kalafatović, Miguel Castanho and David Andreu

Zagreb, Croatia

https://msworkshop.chem.pmf.unizg.hr/speakers.html

20.09.2023.

ANTIVIRAL PEPTIDE-PORPHYRIN CONJUGATES CAPABLE OF CROSSING BLOOD-BRAIN AND BLOOD-PLACENTAL BARRIERS

T. Todorovski,* G. Guida, D. A. Mendonça, C. Cruz-Oliveira, L. Fernandes Siqueira, M. Cavaco, V. Neves, S. Veiga, A. Da Poian, M. Castanho and D. Andreu*

Zagreb, Croatia

https://www.eurpepsoc.com/a-report-on-the-peptide-chemistry-day-symposium/

26.03.2021.

Peptide medicinal chemistry: A promising branch of the modern medicine

Toni Todorovski

Rijeka, Croatia

25.08.2024. - 29.08.2024.

Redox, steady, go: unleashing the catalytic potential of cysteine-rich peptides

Patrizia Janković*, Toni Todorovski, Daniela Kalafatovic

Poster

37th European Peptide Symposium 14th International Peptide Symposium Florence, Italy

https://eps2024.com/

25.08.2024. - 29.08.2024.

Targeting Zika virus reservoirs in mice brain with peptide-porphyrin conjugates

Christine Cruz-Oliveira*, Diogo Alexandre de Mendonça, Lorena O. Fernandes-Siqueira, Toni Todorovski, Ana S. Silva-Herdade, Daniel Gavino-Leopoldino, Beatriz Vieira-da-Silva, Tiago Santos, António Camarão, Javier Valle, Iris Cadima-Couto, Vera Neves, Ana Salomé Veiga, Iranaia Assunção-Miranda, Andrea Thompson Da Poian, David Andreu, Miguel Castanho

Poster

37th European Peptide Symposium 14th International Peptide Symposium Florence, Italy

https://eps2024.com/

25.08.2024. - 29.08.2024.

New peptide-porphyrin conjugates targeting brain-residing viruses

Todorovski T*, Guida G, Janković P, Mendonça D, Cruz-Oliveira C, Cavaco M, Kalafatovic D, Defaus S, Da Poian A, Castanho M, Andreu D

Poster

37th European Peptide Symposium 14th International Peptide Symposium Florence, Italy

https://eps2024.com/

15.10.2023. - 20.10.2023.

New effective peptide-porphyrin conjugates against Zika and other brain-targeting viruses.

T. Todorovski*, S. Defaus, G. Guida, D. A. Mendonça, C. Cruz-Oliveira, L. Fernandes Siqueira, M. Cavaco, V. Neves, S. Veiga, A. Da Poian, M. Castanho and D. Andreu

Oral presentation + poster

13th International Peptide Symposium, 15th Australian Peptide Conference Brisbane, Australia

https://www.peptides2023.org/

20.09.2023.

ANTIVIRAL PEPTIDE-PORPHYRIN CONJUGATES CAPABLE OF CROSSING BLOOD-BRAIN AND BLOOD-PLACENTAL BARRIERS

T. Todorovski,* G. Guida, D. A. Mendonça, C. Cruz-Oliveira, L. Fernandes Siqueira, M. Cavaco, V. Neves, S. Veiga, A. Da Poian, M. Castanho and D. Andreu*

Oral presentation

Peptide Chemistry Day Symposium Zagreb, Croatia

https://www.eurpepsoc.com/a-report-on-the-peptide-chemistry-day-symposium/

08.2022.

New antiviral peptide-drug conjugates active against Zika virus

Todorovski, T* (Todorovski, Toni) ; Mendonca, D (Mendonca, Diogo) ; Guida, G (Guida, Giuseppina) ; Cruz-Oliveira, C (Cruz-Oliveira, Christine) ; Siquiera, LF (Fernandes Siquiera, Lorena) ; Da Poian, A (Da Poian, Andrea) ; Castanho, M (Castanho, Miguel) ; Andreu, D (Andreu, David)

Poster

36th European and the 12th International Peptide Symposium Sitges, Barcelona, Spain

https://www.webofscience.com/wos/woscc/full-record/WOS:000968566400371

08.2022.

Studies on peptide-porphyrin conjugates: a novel strategy to target dengue virus in the central nervous system

Cruz-Oliveira, C* (Cruz-Oliveira, Christine) ; Mendonca, DA (Mendonca, Diogo A.) ; Fernandes-Siqueira, LO (Fernandes-Siqueira, Lorena O.) ; Todorovski, T (Todorovski, Toni) ; Neves, V (Neves, Vera) ; Cadima-Couto, I (Cadima-Couto, Iris) ; Veiga, AS (Veiga, Ana Salome) ; Poian, AT (Da Poian, Andrea T.) ; Andreu, D (Andreu, David) ; Castanho, MARB (Castanho, Miguel A. R. B.)

Poster

36th European and 12th International Peptide Symposium EPS 2022 Barcelona, Spain

https://www.webofscience.com/wos/woscc/full-record/WOS:000968566400384

06.2022.

Peptide-porphyrin conjugates as promising antivirals against brain-targeting viruses

T. Todorovski*, D. A. Mendonça, G. Guida, C. Cruz-Oliveira, L. Fernandes Siquiera, M. Cavaco, V. Neves, S. Veiga, A. Da Poian, M. Castanho and D. Andreu

Oral presentation

17th Naples Workshop on Bioactive Peptides Naples, Italy

2022

Anti-Zika virus and anti-Dengue virus peptide-porphyrin conjugates able to translocate the bloodbrain and bloodplacental barriers-mechanism of action and pharmacokinetics

Vieira da Silva, B*; Mendonca, DA; Fernandes-Siqueira, LO; Cruz-Oliveira, C; Guida, G; Valle, J; Cavaco, M; Neves, V; Todorovski, T; Da Poian, AT;

Poster

FEBS OPEN BIO Lisbon, Portugal

https://www.webofscience.com/wos/woscc/full-record/WOS:000821444602010

2022

Targeting brain-resident viruses across the blood-brain barrier in vitro using peptideporphyrin conjugates

Mendoncá, DA; Cruz-Oliveira, C; Cadima-Couto, I; Fernandes-Siqueira, L; Neves, V; Defaus, S; Veiga, AS; Todorovski, T; Andreu, D; Da Poian, AT;

Oral presentation

FEBS OPEN BIO Lisbon, Portugal

https://www.webofscience.com/wos/woscc/full-record/WOS:000821444602009

02.2020.

Fighting central nervous system arboviral infections with peptide/porphyrin based conjugates

D. A. Mandonça, C. Cruz-Oliveira, L. O. Fernandes-Siqueira, L. S. Da Costa T. Todorovski, V. Neves, I. Cadima-Couto, A. S. Veiga, A. T. Da Poian, D. Andreu and M. A. R. B. Castanho

Poster

17th Iberian Peptide Meeting Madrid, Spain

02.2020.

Development of new ZIKV-active porphyrin-peptide conjugates

Toni Todorovski, Diogo Alexandre de Mendonça, Mariët Bakker, Christine Cruz-Oliveira, Salomé Veiga, Miguel Castanho, David Andreu

Oral presentation

17th Iberian Peptide Meeting Madrid, Spain

11.2019.

NoViruses2Brain

Toni Todorovski and David Andreu

Oral presentation

DCEXS-UPF Symposium 2019 Barcelona, Spain

02.2018.

A new peptide-based approach towards Friedreich´s ataxia treatment

T. Todorovski, M. Sánchez-Navaro and E. Giralt

Poster

16th Iberian Peptide Meeting Barcelona, Spain

09.2017.

Towards a replacement therapy for Friedreich´s ataxia: Synthesis and characterization of frataxin structural fragments conjugated with BBB shuttles

Toni Todorovski, Macarena Sánchez-Navaro and Ernest Giralt

Oral presentation

24th Polish Peptide Symposium Gdansk, Poland

08.2014.

Cysteine-free native chemical ligation promoted by HOBt

T. Todorovski, D. Suñol, A. Riera and M. J. Macias

Poster

EMBO conference series "Chemical Biology 2014" Heidelberg, Germany

04.2014.

An improved cysteine-free native chemigal ligation approach for chemical synthesis of polypeptides and small proteins

T. Todorovski, D. Suñol and M. J. Macias

Poster

1st IRB Barcelona Postdoc Day Barcelona, Spain

03.2014.

An immproved cysteine-free native chemical ligation approach for chemical synthesis of polypeptides and small proteins

T. Todorovski, D. Suñol and M. J. Macias

Oral presentation

21st Young Research Fellow Meeting „Assets of Chemistry in Drug Discovery Montpellier, France

11.2013.

Synthesis of polypeptides and proteins using an improved cysteine-free native chemical ligation approach

T. Todorovski, D. Suñol and M. J. Macias

Poster

3rd IRB Barcelona PhD Symposium „The clock of Life“ Barcelona, Spain

11.2011.

Breaking the wall of ageing and age-related diseases

Toni Todorovski

Oral presentation

Falling Walls Lab 2011 Berlin, Germany

12.2009.

Synthesis and mass spectrometric analysis of 5-OH-tryptophan and oxyndolylalanine-containing peptides

T. Todorovski, M. Fedorova and R. Hoffmann

Poster

Leipzig Research Festival for Live Sciences 2009 Leipzig, Germany

05.2009.

Synthesis and mass spectrometrical characterization of model peptides containing oxidized tryptophan residues relevant for protein aging

Toni Todorovski and Ralf Hoffmann

Poster

Biotechnologietag Leipzig, Germany

03.2008.

Synthesis and mass spectrometrical characterization of model peptides containing oxidized tryptophan residues relevant for protein aging

Toni Todorovski and Ralf Hoffman

Oral presentation

Meeting of Analytical Chemists Oppurg, Germany

23.02.2023.

ANTI-INFECTIVE CONJUGATE FOR USE IN THE TREATMENT OF ZIKA VIRUS INFECTION The present invention relates to a conjugate of protoporphyrin IX with a peptide or a salt or a co-crystal thereof for use in the prevention or treatment of Zika virus infection. It also relates to a pharmaceutical composition comprising said conjugate and a pharmaceutically acceptable diluent or carrier for use in the prevention or treatment of Zika virus infection. The use of the conjugate for the manufacture of a medicament for the prevention or treatment of Zika virus infection is also encompassed by the present invention as well as methods of prevention or treatment of Zika virus infection in patients in need thereof.

ANDREU MARTÍNEZ, David TODOROVSKI, Toni CRUZ OLIVEIRA, Christine THOMPSON DA POIAN, Andrea FERNANDES SIQUEIRA, Lorena de Oliveira RICO BOTAS CASTANHO, Miguel Augusto ALEXANDRE DE MENDONÇA, Diogo

01.03.2022. - 20.05.2023.

Pharmaceutics, Special Issue "Application of Peptide-Drug-Conjugates in the Treatment of Cancer and Microbial Infections"

https://www.mdpi.com/journal/pharmaceutics/special_issues/peptide_drug

31.07.2023.

Obtaining of New Antioxidant and Antimicrobial Peptides Derived from Human Hemoglobin by Peptide Hydrolysis and Comparison with These Obtained by Bovine Hemoglobin

International Journal of Molecular Sciences

14.07.2023.

Novel Dipeptides Incorporating Sulphonamide Functionality: Synthesis, Biological and Computational Studies

Molecules

20.04.2023.

DA7R: A 7-Letter Zip Code to Target PDAC

Pharmaceutics

28.03.2023.

Anti-BVDV Activity of Traditional Chinese Medicine Monomers Targeting NS5B (RNA-Dependent RNA Polymerase) In Vitro and In Vivo

Molecules

16.03.2023.

Shotgun Proteomics Analysis, Functional Networks and Peptide Biomarkers for Seafood Biogenic Amine-Producing Bacteria

International Journal of Molecular Sciences

29.12.2022.

Antiviral Evaluation of New Synthetic Bioconjugates Based on GA-Hecate: A New Class of Antivirals Targeting Different Steps of Zika Virus Replication

Viruses

27.07.2021.

Improving Solid Phase Synthesis of Long Peptides Using Ultrasonication - A Comparative Study

Journal of Peptide Science

28.04.2024. -

Antivirusni peptid-porfirin konjugati s poboljšanom stabilnošću i djelovanjem protiv virusa koji napadaju mozak; Antiviral peptide-porphyrin conjugates with improved stability and activity against brain-residing viruses

Voditelj

Sveučilište u Rijeci 5803,07

https://uniri.hr/wp-content/uploads/2024/04/Prilog-1_Konacna-lista-projekata_UNIRI-ISKUSNI-2023.pdf

28.04.2024. -

Predviđanje terapeutskih peptida zasnovano na dubokom učenju

Suradnik

Sveučilište u Rijeci 6333,03

01.02.2020. - 31.01.2025.

Dizajn katalitički aktivnih peptida i peptidnih nanostruktura

Suradnik

HRZZ (UIP-2019-04-7999)

2019. - 2024.

NOVIRUSES2BRAIN

Posljedoktorand, nositelj projekta iz tima iz Barcelone

European Union (Horizon 2020 Framework Programme, grant no 828774)

2018. - 2021.

NOZIKA: Fighting Zika virus with antiviral peptides and conjugates translocating blood-placental and blood-brain barriers

Posljedoktorand, nositelj projekta iz tima iz Barcelone

La Caixa Health Foundation (project HR17_00409, ID 100010434, agreement LCF/PR/HR17/52150011)

2017. - 2019.

Lanzaderas peptídicas para el desarrollo de una terapia de reemplazamiento proteico de la Ataxia de Friedreich

Posljedoktorand nositelj projekta

BabelFAmily

2015. - 2018.

Desarrollo de Inmunoterapias anti-tumorales de segunda generación: Anticuerpos y Nanobodies conjgados con toxinas de forma específica mediante Inteínas - ZIP

Posljedoktorand suradnik

Ministerio de Ciencia e Innovación, Gobierno de España

01.11.2012. - 31.08.2014.

FP7 Marie-Curie COFUND

Posljedoktorand nositelj projekta

Europska Komisija, Marie Skłodowska-Curie Actions, Horizon 2020

01.10.2007. - 31.12.2010.

Synthesis and analysis of model peptides containing oxidized tryptophan residues relevant for aging

Doktorand nositelj projekta

DAAD (Deutscher Akademischer Austauschdienst)