2022.

doktor znanosti

Poslijediplomski studij Biomedicina

Sveučilište u Rijeci, Medicinski fakultet

2005. - 2011.

doktor medicine

Integrirani preddiplomski i diplomski studij medicine

Sveučilište u Rijeci, Medicinski fakultet

2016. -

liječnik

liječnik obiteljske medicine, specijalizant

Dom zdravlja Primorsko - goranske županije

17.06.2013. - 16.06.2016.

Viši stručni suradnik u sustavu znanosti i visokom obrazovanju – doktorandica

doktorandica, istraživački rad i sudjelovanje u izvedbi nastavnog plana

Centar za proteomiku, Medicinski Fakulter sveučilišta u Rijeci

03.10.2012. - 02.10.2012.

liječnik

liječnik pripravnik (stažist)

Klinički bolnički centar, Rijeka

3013. - 2016.

Histologija i embriologija

Integrirani preddiplomski i diplomski studij medicine

Medicinski fakultet, Sveučilište u Rijeci

Asistent

2022. -

Obiteljska medicina

Integrirani preddiplomski i diplomski studij medicine

Medicinski fakultet, Sveučilište u Rijeci

naslovni asistent

2021.

Family Physician's Educational Interview with Patients Helps in Early Recognition of Lower Urinary Tract Symptoms

Ana Lesac Brizić, Vladimir Mozetič

Purpose: Lower urinary tract symptoms (LUTS) can have an etiology outside the lower urinary tract (LUT) and are therefore an important diagnostic indicator for assessing the overall health of a person. However, LUTS is still mainly neglected by primary health care providers as well as by patients. In this study, we assessed the importance of an educational interview (EI) conducted by a GP on the patients’ ability to recognize LUTS. We also investigated other factors that affect the recognition of LUTS: subjects’ personal educational level, number of LUT symptoms and their bothersome level on a scale 0– 10. Patients and Methods: This cross-sectional study was conducted in Croatia (2018– 2020) by interviewing 499 subjects. We compared recognized LUT symptoms before and after the EI and determined whether their number, their bothersome level, or the subjects’ personal educational level were associated with LUTS recognition. Results: EI significantly improved the ability to recognize LUTS (p=0.001). The number of LUT symptoms and bothersome level in subjects before EI was much greater than the number in subjects after EI (p< 0.0001, mean> 4 and p< 0.0001, median> 8, respectively). Subjects with higher educational level recognized LUTS with fewer symptoms after the EI (p< 0.01), but no difference was observed among subjects who recognized LUTS before the EI. Conclusion: For subjects to recognize LUTS, their condition had to be severe – more than 4 symptoms and bothersome level > 8/10. Personal educational level had little impact on LUTS recognition. However, an EI proved to be an excellent tool for raising awareness about LUTS and its early recognition. - 14 9689-9696

Q2

2017.

Cytomegalovirus vector expressing RAE-1γ induces enhanced anti-tumor capacity of murine CD8+ T cells

Tihana Tršan, Kristina Vuković, Petra Filipović, Ana Lesac Brizić, Niels A W Lemmermann, Kilian Schober, Dirk H Busch, William J Britt, Martin Messerle, Astrid Krmpotić, Stipan Jonjić

Designing CD8+ T-cell vaccines, which would provide protection against tumors is still considered a great challenge in immunotherapy. Here we show the robust potential of cytomegalovirus (CMV) vector expressing the NKG2D ligand RAE-1γ as CD8+ T cell-based vaccine against malignant tumors. Immunization with the CMV vector expressing RAE-1γ, delayed tumor growth or even provided complete protection against tumor challenge in both prophylactic and therapeutic settings. Moreover, a potent tumor control in mice vaccinated with this vector can be further enhanced by blocking the immune checkpoints TIGIT and PD-1. CMV vector expressing RAE-1γ potentiated expansion of KLRG1+ CD8+ T cells with enhanced effector properties. This vaccination was even more efficient in neonatal mice, resulting in the expansion and long-term maintenance of epitope-specific CD8+ T cells conferring robust resistance against tumor challenge. Our data show that immunomodulation of CD8+ T-cell responses promoted by herpesvirus expressing a ligand for NKG2D receptor can provide a powerful platform for the prevention and treatment of CD8+ T-cell sensitive tumors. - 47 1354-1367

Q1

2011.

Health-related quality of life in the patients on maintenance hemodialysis: the analysis of demographic and clinical factors

Daniela Germin-Petrović, Iva Mesaros-Devcić, Ana Lesac, Marin Mandić, Marin Soldatić, Dragana Vezmar, Daniela Petrić, Bozidar Vujicić, Nikolina Basić-Jukić, Sanjin Racki

Health-related quality of life (HRQoL) among hemodialysis (HD) patients recently became a nephrologist's focus of interest. HRQoL is an important predictor of outcome in HD patients and need to be regularly assessed. The aim of the present study was to compare the HRQoL of chronic HD patients with general population and to analyze influencing sociodemographic and clinical factors. We included 255 prevalent HD patients from four dialysis centers. HRQoL was measured with The Medical Outcomes Study Short Form 36 Health Survey Questionnaire (SF-36). This data were compared with control group (N = 132) from the general Croatian population. Comparisons of SF-36 scale scores of HD patients regarding demographic and clinical factors (age, gender, education level, dialysis vintage and diabetes) were also performed and analyzed with a multivariate regression analysis. HRQoL in prevalent HD patients was relatively low (mean Physical Component Summary, PCS = 33.7, mean Mental Component Summary, MCS = 43.0) and was lower compared to the control group from the general population in all HRQoL domains, PCS and MCS scores. Almost 53% of the HD patients had the critical score PCS < 43 + MCS < 51 as the predictor of death and hospitalization. Better HRQoL was revealed in the patients < 65 years old, males, patients with higher educational level and in the patients on maintenance HD less than one year. Age was the only statistically significant predictor of PCS and MCS. Developments of HD technology, treatment of comorbidities, continuous patients' education, social and psychological support and use of other renal replacement modalities, especially kidney transplantation, may improve the HRQoL in these patients. - 35 687-93