PORTFELJ / Prof.dr.sc. Robert Domitrović univ.mag.med.biokem.

Portfelj

Prof.dr.sc.

Robert Domitrović

univ.mag.med.biokem.

Medicinski fakultet

Zavod za medicinsku kemiju, biokemiju i kliničku kemiju

Kontakt

Vidljivost

Obrazovanje

1997. - 1999.

Doktor znanosti, područje biomedicina i zdravstvo, polje farmacija

Poslijediplomski doktorski studij - biomedicina i zdravstvo

Farmaceutsko-biokemijski fakultet Sveučilišta u Zagrebu

1992. - 1997.

Magistar znanosti, područje prirodne znanosti, polje kemija, grana fizikalna kemija

Poslijediplomski studij prirodnih znanosti - kemija

Prirodoslovno-matematički fakultet Sveučilišta u Zagrebu

1987. - 1991.

Dipl. ing. medicinske biokemije

Medicinska biokemija

Farmaceutsko-biokemijski fakultet Sveučilišta u Zagrebu

Radno iskustvo

2017. -

Redoviti profesor u trajnom zvanju

pročelnik Zavoda, nastava, znanstveno-istraživački rad, stručni rad

Zavod za medicinsku kemiju, biokemiju i kliničku kemiju Medicinskog fakulteta Sveučilišta u Rijeci

2012. - 2017.

Redoviti profesor

nastava, znanstveno-istraživački rad, stručni rad

Zavod za kemiju i biokemiju Medicinskog fakulteta Sveučilišta u Rijeci

2007. - 2012.

Izvanredni profesor

nastava, znanstveno-istraživački rad, stručni rad

Zavod za kemiju i biokemiju Medicinskog fakulteta Sveučilišta u Rijeci

2002. - 2007.

Docent

nastava, znanstveno-istraživački rad, stručni rad

Zavod za kemiju i biokemiju Medicinskog fakulteta Sveučilišta u Rijeci

1999. - 2002.

Viši asistent

nastava, znanstveno-istraživački rad, stručni rad

Zavod za kemiju i biokemiju Medicinskog fakulteta Sveučilišta u Rijeci

1996. - 1999.

Asistent

nastava i znastveno-istraživački rad

Zavod za kemiju i biokemiju Medicinskog fakulteta Sveučilišta u Rijeci

1991. - 1996.

Stručni suradnik

nastava, znastveno-istraživački rad

Zavod za kemiju i biokemiju Medicinskog fakulteta Sveučilišta u Rijeci

Članstva

2006. -

Hrvatsko društvo biokemičara i molekularnih biologa

2005. -

Prosudbena skupina za ocjenu udžbenika "Medicinska biokemija", Ljerka Išgum-Vorgić, za učenike Srednjih medicinskih škola

2001. - 2005.

Tehnički odbor 147 (Kakvoća vode), pododbora 5 (Biološka ispitivanja) i pododbor 6 (Uzorkovanje) Hrvatkog zavoda za norme

1995. -

Hrvatsko kemijsko društvo

1993. -

Hrvatsko društvo medicinskih biokemičara

Nastavna djelatnost

Kolegiji

2008. -

laboratorijska dijagnostika

Medicinska radiologija

Zavod za kemiju i biokemiju Medicinskog fakulteta Sveučilišta u Rijeci

voditelj

2007. -

Oksidativni stres i antioksidansi

Medicina

Zavod za kemiju i biokemiju Medicinskog fakulteta Sveučilišta u Rijeci

voditelj

2000. - 2005.

Biokemijske metode

Medicina

Zavod za kemiju i biokemiju Medicinskog fakulteta Sveučilišta u Rijeci

suradnik

1996. - 2000.

Enzimi u dijagnostici

Medicina

Zavod za kemiju i biokemiju Medicinskog fakulteta Sveučilišta u Rijeci

suradnik

1993. -

Kemija

Stomatologija

Zavod za kemiju i biokemiju Medicinskog fakulteta Sveučilišta u Rijeci

suradnik

1993. -

Kemija

Medicina

Zavod za kemiju i biokemiju Medicinskog fakulteta Sveučilišta u Rijeci

suradnik

1993. -

Biokemija

Sanitarno inženjerstvo

Zavod za kemiju i biokemiju Medicinskog fakulteta Sveučilišta u Rijeci

suradnik

1993. -

Biokemija

Stomatologija

Zavod za kemiju i biokemiju Medicinskog fakulteta Sveučilišta u Rijeci

suradnik

1993. -

Biokemija

Medicina

Zavod za kemiju i biokemiju Medicinskog fakulteta Sveučilišta u Rijeci

suradnik

1993. -

Kemija

Sanitarno inženjerstvo

Zavod za kemiju i biokemiju Medicinskog fakulteta Sveučilišta u Rijeci

suradnik

Mentor u završnim radovima

05.07.2013. -

Nefroprotektivnan učinak ružmarinske kiseline kod oštećenja bubrega uzrokovanim cisplatinom /

Iva Potočnjak

Sanitarno inženjerstvo

Zavod za kemiju i biokemiju Medicinskog fakulteta Sveučilišta u Rijeci

20.04.2012. -

Rutin učinkovitije od kvercetina sprječava oštećenje jetre tetraklorugljikom u BALB/cN miševa

Žarko Tadić

Sanitarno inženjerstvo

Zavod za kemiju i biokemiju Medicinskog fakulteta Sveučilišta u Rijeci

17.03.2012. -

Zaštitni učinak antocijanidina delfinidina na akutno oštećenje jetre u miševa

Anja Cergolj

Sanitarno inženjerstvo

Zavod za kemiju i biokemiju Medicinskog fakulteta Sveučilišta u Rijeci

12.07.2011. -

Preventivni i terapijski učinak oleuropeina u akutnom oštećenju jetre kod BALB/cN miševa

Ivana Šain

Sanitarno inženjerstvo

Zavod za kemiju i biokemiju Medicinskog fakulteta Sveučilišta u Rijeci

31.01.2011. -

Hepatoprotektivan učinak berberina u oštećenju jetre s tetraklorugljikom

Ana Bandić

Medicinsko-laboratorijska dijagnostika

Zavod za kemiju i biokemiju Medicinskog fakulteta Sveučilišta u Rijeci

02.12.2010. -

Dinamika oštećenja jetre tetraklorugljikom: hepatoprotektivno djelovanje berberina

Sanda Šever

Medicinsko-laboratorijska dijagnostika

Zavod za kemiju i biokemiju Medicinskog fakulteta Sveučilišta u Rijeci

24.09.2009. -

Terapijski učinak ekstrakta korijena maslačka na fibrozu jetre inducirane tetraklorugljikom u Balb/C miševa

Žarko Tadić

Sanitarno inženjerstvo

Zavod za kemiju i biokemiju Medicinskog fakulteta Sveučilišta u Rijeci

14.07.2009. -

Terapijski učinak luteolina na fibrozu jetre u Balb/C miševa

Ivana Šain

Sanitarno inženjerstvo

Zavod za kemiju i biokemiju Medicinskog fakulteta Sveučilišta u Rijeci

16.02.2008. -

Luteolin u prevenciji akutnog oštećenja jetre induciranog tetraklorugljikom

Mihaela Staver

Sanitarno inženjerstvo

Zavod za kemiju i biokemiju Medicinskog fakulteta Sveučilišta u Rijeci

22.12.2006. -

Utjecaj prehrane na sastav masnih kiselina i lipidnu peroksidaciju u jetri Balb/C miševa

Dalibor Tota

Medicinsko-laboratorijska dijagnostika

Zavod za kemiju i biokemiju Medicinskog fakulteta Sveučilišta u Rijeci

29.09.1999. -

Cink i katalitička aktivnost alkalne fosfataze tijekom kompenzacijskog rasta jetre

Maurizio Benzan

Medicinsko-laboratorijska dijagnostika

Zavod za kemiju i biokemiju Medicinskog fakulteta Sveučilišta u Rijeci

29.09.1999. -

Cink i katalitička aktivnost 5-nukleotidaze tijekom kompenzacijskog rasta jetre

Alem Kasami

Medicinsko-laboratorijska dijagnostika

Zavod za kemiju i biokemiju Medicinskog fakulteta Sveučilišta u Rijeci

Znanstvena djelatnost

Znanstveni radovi

2023.

Proteins in urine - possible biomarkers of endometriosis

Višnić, Alenka; Čanadi Jurešić, Gordana; Domitrović, Robert; Klarić, Marko; Sušanj Šepić, Tina; Barišić, Dubravko

Journal of Reproductive Immunology - 103941

Q1 WOS

2023.

Sinomenine mitigates cisplatin-induced kidney injury by targeting multiple signaling pathways

Potočnjak, Iva; Šimić, Lidija; Batičić, Lara; Križan, Hrvoje; Domitrović, Robert

Food and Chemical Toxicology - 171 13538

Q1 WOS

2022.

Unveiling the native morphology of extracellular vesicles from human cerebrospinal fluid by atomic force and cryogenic electron microscopy

Kurtjak, Mario; Kereïche, Sami; Klepac, Damir; Križan, Hrvoje; Perčić, Marko; Krušić Alić, Vedrana; Lavrin, Teja; Lenassi, Metka; Wechtersbach, Karmen; Kojc, Nika; Vukomanović, Marija; Zrna, Siniša; Biberić, Maša; Domitrović, Robert; Grabušić, Kristina; Malenica, Mladenka

Biomedicines - 10 1251

Q1 WOS

2022.

Oleanolic acid induces HCT116 colon cancer cell death through the p38/FOXO3a/Sirt6 pathway

Potočnjak, Iva; Šimić, Lidija; Vukelić, Iva; Batičić, Lara; Domitrović, Robert

Chemico-Biological Interactions - 363 110010

Q1 WOS

2020.

Luteolin ameliorates experimental colitis in mice through ERK-mediated suppression of inflammation, apoptosis and autophagy

Vukelić, Iva; Detel, Dijana; Batičić, Lara; Potočnjak, Iva; Domitrović, Robert .

Food and Chemical Toxicology - 145 111680

Q1 WOS

2020.

Aucubin administered by either oral or parenteral route protects against cisplatin-induced acute kidney injury in mice.

Potočnjak, Iva; Marinić, Jelena; Batičić, Lara; Šimić, Lidija; Broznić, Dalibor; Domitrović, Robert

Food and Chemical Toxicology - 142 111472

https://www.sciencedirect.com/science/article/abs/pii/S0887233319309245?via%3Dihub

Q1 WOS

2020.

Antitumor activity of luteolin in human colon cancer SW620 cells is mediated by the ERK/FOXO3a signaling pathway.

Potočnjak, Iva; Šimić, Lidija; Gobin, Ivana; Vukelić, Iva; Domitrović, Robert

Toxicology In Vitro - 66 104852

https://www.sciencedirect.com/science/article/abs/pii/S0887233319309245?via%3Dihub

Q1 WOS

2019.

Oleanolic acid attenuates cisplatin-induced nephrotoxicity in mice and chemosensitizes human cervical cancer cells to cisplatin cytotoxicity.

Potočnjak, Iva; Šimić, Lidija; Vukelić, Iva; Domitrović, Robert

Food and Chemical Toxicology - 132 110676

https://www.sciencedirect.com/science/article/abs/pii/S027869151930465X?via%3Dihub

Q1

2018.

Chlorogenic acid ameliorates experimental colitis in mice by suppressing signaling pathways involved in inflammatory response and apoptosis

Vukelić, Iva; Detel, Dijana; Pučar Batičić, Lara; Potočnjak, Iva; Buljević, Sunčica; Domitrović, Robert

Food and Chemical Toxicology - 121 140-150

https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(18)30618-5

Q1

2018.

Carvacrol induces cytotoxicity in human cervical cancer cells but causes cisplatin resistance: Involvement of MEK-ERK activation.

Potočnjak, Iva; Gobin, Ivana; Domitrović, Robert

Phytotherapy Research - 32 1090-7

https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.6048

Q1

2017.

Stevia and stevioside protect against cisplatin nephrotoxicity through inhibition of ERK1/2, STAT3, and NF-?B activation.

Potočnjak, Iva; Broznić, Dalibor; Kindl, Marija; Kropek, Matija; Vladimir-Knežević, Sanda;, Domitrović, Robert

Food and Chemical Toxicology - 107 215-225

http://www.sciencedirect.com/science/article/pii/S0278691517303617

Q1

2017.

Hippocampal expressions of metallothionein I/II and glycoprotein 96 in EAE-prone and EAE-resistant strains of rats.

Grubić Kezele, Tanja; Blagojević Zagorac, Gordana; Jakovac, Hrvoje; Domitrović, Robert; Radošević-Stašić, Biserka

Histology and Histopathology - 32 137-151

http://www.hh.um.es/Abstracts/Vol_32/32_2/32_2_137.htm

Q2

2016.

Carvacrol attenuates acute kidney injury induced by cisplatin through suppression of ERK and PI3K/Akt activation.

Potočnjak Iva; Domitrović Robert.

Food and Chemical Toxicology - 98 251-261

http://www.sciencedirect.com/science/article/pii/S0278691516304057

Q1

2016.

High-fat diet induced changes in lumbar vertebra of the male rat offsprings.

Perić Kačarević Željka; Šnajder Darija; Marić Anđela; Bijelić N, Cvijanović Olga; Domitrović Robert; Radić Radivoje

Acta Histochemica - 118 711-721

http://www.sciencedirect.com/science/article/pii/S006512811630160X

WOS

2016.

Oral administration of oleuropein attenuates cisplatin-induced acute renal injury in mice through inhibition of ERK signaling.

Potočnjak, Iva; Škoda, marko; Pernjak-Pugel, Ester; Pavletić Peršić, Martina; Domitrović, Robert

Molecular Nutrition & Food Research - 60 530-541

http://onlinelibrary.wiley.com/doi/10.1002/mnfr.201500409/abstract;jsessionid=9C05D4C14FD4840663B02B22918BFF75.f03t03

Q1

2016.

A comprehensive overview of hepatoprotective compounds of plant origin: mechanism of action and clinical perspectives.

Domitrović, Robert; Potočnjak, Iva

Archives of Toxicology - 90 39-79

http://link.springer.com/article/10.1007/s00204-015-1580-z

Q1

2015.

Hepatoprotective and antifibrotic effects of Micromeria croatica ethanolic extract against CCl4-induced acute liver injury in mice.

Vladimir-Knežević, Sanda; Cvijanović, Olga; Bival Štefan, Maja; Blažeković, Biljana; Kindl, Marija; Domitrović, Robert

BMC Complementary and Alternative Medicine - 15 233

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501215/

Q2

2015.

Myricitrin exhibits antioxidant, anti- inflammatory and antifibrotic activity in carbon tetrachloride-intoxicated mice

Domitrović, Robert; Rashed, Khaled; Vladimir- Knežević, Sanda; Cvijanović, Olga; Škoda, Marko; Višnić, Alenka

Chemico-biological Interactions - 230 21-29

http://www.sciencedirect.com/science/article/pii/S000927971500054X

Q1

2014.

Renoprotective mechanisms of chlorogenic acid in cisplatin-induced kidney injury.

Domitrović, Robert; Cvijanović, Olga; Šušnić, Vesna; Katalinić, Nataša.

Toxicology - 324 98-107

http://www.sciencedirect.com/science/article/pii/S0300483X14001371

Q1

2014.

Terminalia bellerica aerial parts ethyl acetate extract exhibits antioxidant, anti-inflammatory and antifibrotic activity in carbon tetrachloride-intoxicated mice

Rashed, Khaled; Potočnjak, Iva; Giacometti, Jasminka; Škoda, Marko; Domitrović, Robert

Journal of Functional Foods - 8 319-330

http://www.sciencedirect.com/science/article/pii/S1756464614001327

Q1

2014.

Nephroprotective activities of rosmarinic acid against cisplatin-induced kidney injury in mice

Domitrović, Robert; Potočnjak, Iva; Crnčević-Orlić, Željka; Škoda, Marko

Food and Chemical Toxicology - 66 321-328

http://www.sciencedirect.com/science/article/pii/S0278691514000799

Q1

2013.

Hepatic expression of metallothionein I/II, glycoprotein 96, IL-6, and TGF-beta in rat strains with different susceptibility to experimental autoimmune encephalomyelitis

Grubić-Kezele, Tanja; Blagojević Zagorac, Gordana; Jakovac, Hrvoje; Domitrović, Robert; Milin, Čedomila; Radošević-Stašić, Biserka

Clinical & Developmental Immunology - 750406

http://www.hindawi.com/journals/jir/2013/750406/

Q2

2013.

Berberine exerts nephroprotective effect against cisplatin-induced kidney damage through inhibition of oxidative/nitrosative stress, inflammation, autophagy and apoptosis

Domitrović, Robert; Cvijanović, Olga; Pernjak- Pugel, Ester; Škoda, Marko; Mikelić, Lorena; Crnčević-Orlić, Željka

Food and Chemical Toxicology - 62 397-406

http://www.sciencedirect.com/science/article/pii/S0278691513006418

Q1

2013.

Resolution of liver fibrosis by isoquinoline alkaloid berberine in CCl4-intoxicated mice is mediated by up-regulation of MMP-2 expression

Domitrović, Robert; Jakovac, Hrvoje; Vasiljev Marchesi, Vanja; Blažeković, Biljana

Journal of Medicinal Food - 16 518-528

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684211/

Q2

2013.

Rosmarinic acid ameliorates acute liver damage and fibrogenesis in carbon tetrachloride-intoxicated mice

Domitrović, Robert; Škoda, Marko; Vasiljev Marchesi, Vanja; Cvijanović, Olga; Pernjak Pugel, Ester; Bival Štefan, Maja

Food and Chemical Toxicology - 51 370-378

http://www.sciencedirect.com/science/article/pii/S0278691512007661

Q1

2013.

Luteolin ameliorates cisplatin-induced nephrotoxicity in mice through inhibition of platinum accumulation, inflammation and apoptosis in the kidney

Domitrović, Robert; Cvijanović, Olga; Pernjak Pugel, Ester; Blagojević Zagorac, Gordana; Mahmutefendić, Hana; Škoda, Marko

Toxicology - 310 115-123

http://www.sciencedirect.com/science/article/pii/S0300483X13001534

Q1

2012.

Hepatoprotektivno djelovanje fitokemikalija

Domitrović, Robert

Medicina Fluminensis - 48 4-14

2012.

Preventive and therapeutic effects of oleuropein against carbon tetrachloride-induced liver damage in mice

Domitrović, Robert; Jakovac, Hrvoje; Vasiljev Marchesi, Vanja; Šain, Ivana; Romić, Željko; Rahelić, Dario

Pharmacological Research - 65 451-464

http://www.sciencedirect.com/science/article/pii/S1043661811003082

Q1

2012.

Differential hepatoprotective mechanisms of rutin and quercetin in carbon tetrachloride-intoxicated BALB/cN mice

Domitrović, Robert; Jakovac, Hrvoje; Vasiljev Marchesi, Vanja; Vladimir-Knežević, Sanda; Cvijanović, Olga; Tadić, Žarko; Romić, Željko; Rahelić, Dario

Acta Pharmacologica Sinica - 33 1260-1270

http://www.nature.com/aps/journal/v33/n10/full/aps201262a.html

Q2

2011.

Hepatoprotective activity of berberine is mediated by inhibition of TNF-?, COX-2, and iNOS expression in CCl4-intoxicated mice

Domitrović, Robert; Jakovac, Hrvoje; Blagojević, Gordana

Toxicology - 280 33-43

http://www.sciencedirect.com/science/article/pii/S0300483X10006220

Q1

2011.

Effects of standardized bilberry fruit extract (Mirtoselect®) on resolution of CCl4-induced liver fibrosis in mice

Domitrović, Robert; Jakovac, Hrvoje

Food and Chemical Toxicology - 49 848-854

http://www.sciencedirect.com/science/article/pii/S0278691510007118

Q1

2011.

The molecular basis for the pharmacological activity of anthocyans

Domitrović, Robert

Current Medicinal Chemistry - 18 4454-4469

http://www.eurekaselect.com/75136/article

Q1

2010.

Antifibrotic activity of Taraxacum officinale root in carbon tetrachloride-induced liver damage in mice

Domitrović, Robert; Jakovac, Hrvoje; Romić, Željko; Rahelić, Dario; Tadić, Žarko

Journal of Ethnopharmacology - 130 569-577

http://www.sciencedirect.com/science/article/pii/S0378874110003661

Q1

2010.

Antifibrotic activity of anthocyanidin delphinidin in carbon tetrachloride-induced hepatotoxicity in mice

Domitrović, Robert; Jakovac, Hrvoje

Toxicology - 271 1-10

http://www.sciencedirect.com/science/article/pii/S0300483X10001563

Q1

2009.

Liver fibrosis in mice induced by carbon tetrachloride and its reversion by luteolin

Domitrović, Robert; Jakovac, Hrvoje; Tomac, Jelena; Šain, Ivana

Toxicology and Applied Pharmacology - 241 311-321

http://www.sciencedirect.com/science/article/pii/S0041008X09003767

Q1

2009.

Dose- and time-dependent effects of luteolin on carbon tetrachloride-induced hepatotoxicity in mice

Domitrović, Robert; Jakovac, Hrvoje; Milin, Čedomila; Radošević-Stašić, Biserka

Experimental and Toxicologic Pathology - 61 581-589

http://www.sciencedirect.com/science/article/pii/S0940299308001826

Q3

2008.

Dose- and time-dependent effects of luteolin on liver metallothioneins and metals in carbon tetrachloride-induced hepatotoxicity in mice

Domitrović, Robert; Jakovac, Hrvoje; Grebić, Damir; Milin, Čedomila; Radošević-Stašić, Biserka

Biological Trace Elements Research - 126 176-185

http://link.springer.com/article/10.1007%2Fs12011-008-8181-0

2008.

Differential effect of high dietary iron on alpha-tocopherol and retinol levels in the liver and serum of mice fed olive oil- and corn oil-enriched diets

Domitrović, Robert; Tota, Marin; Milin, Čedomila

Nutrition Research - 28 263-269

http://www.sciencedirect.com/science/article/pii/S0271531708000225

2007.

Lipidna peroksidacija: uzroci i posljedice (Lipid peroxidation: causes and consequences)

Štefan, Leo; Tepšić, Tina; Zavidić, Tina; Urukalo, Marta; Tota, Dalibor; Domitrović, Robert

Medicina: glasilo Hrvatskoga liječničkoga zbora, Podružnica Rijeka - 43 84-94

2006.

Vitamin C u prevenciji i liječenju bolesti (Vitamin C in disease prevention and therapy)

Domitrović, Robert

Biochemia Medica - 16 107-125

2006.

Oxidative stress in mice: effects of dietary corn oil and iron

Domitrović, Robert; Tota, Marin; Milin, Čedomila

Biological Trace Element Research - 113 177-192

2006.

Liver fatty acid and element changes after partial hepatectomy in mice fed olive-oil and corn-oil enriched diet

Domitrović, Robert; Milin, Čedomila; Radošević-Stašić, Biserka

Biological Trace Element Research - 109 61-74

http://link.springer.com/article/10.1385%2FBTER%3A109%3A1%3A061

2005.

Olive and corn-oil enriched diets as modulators of mineral content in submandibular gland during liver regeneration

Milin, Čedomila; Tota, Marin; Domitrović, Robert; Pantović, Radojka; Giacometti, Jasminka; Ćuk, Mira; Mrakovčić-Šutić, Ines; Jakovac, Hrvoje; Radošević-Stašić, Biserka

Croatica Chemica Acta - 78 441-446

2005.

Metal tissue kinetics in regenerating liver, thymus, spleen and submandibular gland after partial hepatectomy in mice

Milin, Čedomila; Marin, Tota; Domitrović, Robert; Giacometti, Jasminka; Pantović, Radojka; Ćuk, Mira; Mrakovčić-Šutić, Ines; Jakovac, Hrvoje; Radošević-Stašić, Biserka

Biological Trace Element Research - 108 225-243

http://link.springer.com/article/10.1385%2FBTER%3A108%3A1-3%3A225

2002.

Dietary fats and tissue mineral concentration in the early phase of liver regeneration

Domitrović, Robert; Milin, Čedomila; Tota, Marin; Ćuk, Mira; Radošević-Stašić, Biserka; Ciganj, Zlatko

Periodicum Biologorum - 104 99-101

WOS

2001.

Regeneracija jetre (Liver regeneration )

Domitrović, Robert; Milin, Čedomila; Benzan, Mauricio; Kasami, Alem

Biochemia Medica - 11 13-19

2001.

Effect of olive oil- and corn oil-enriched diets on the tissue mineral content in mice

Milin, Čedomila; Domitrović, Robert; Tota, Marin; Giacometti, Jasminka; Ćuk, Mira; Radošević-Stašić, Biserka; Ciganj, Zlatko

Biological Trace Element Research - 82 201-210

http://link.springer.com/article/10.1385%2FBTER%3A82%3A1-3%3A201

2000.

Biokemija cinka (Biochemistry of zinc )

Domitrović, Robert; Milin, Čedomila

Biochemia Medica - 10 21-27

1998.

Tissue zinc dynamics during the immune reaction in mice

Verbanac, Donatella; Milin, Čedomila; Radošević-Stašić, Biserka; Trobonjača, Zlatko; Domitrović, Robert; Giacometti, Jasminka; Petković, Marija; Ćuk, Mira; Ciganj, Zlatko; Rupčić, Jasminka; Rukavina, Daniel

Biological Trace Element Research - 65 97-108

http://link.springer.com/article/10.1007%2FBF02784262

1997.

Determination of standard zinc values in the intact tissues of mice by ICP spectrometry

Verbanac, Donatella; Milin, Čedomila; Domitrović, Robert; Giacometti, Jasminka; Pantović, Radojka; Ciganj, Zlatko

Biological Trace Element Research - 57 91-96

http://link.springer.com/article/10.1007%2FBF02803873

1995.

Activation of zinc-dependent hepato-thymic axis during liver regeneration in hepatectomized mice

Milin, Čedomila; Radošević-Stašić, Biserka; Verbanac, Donatella; Domitrović, Robert; Petković, Marija; Trobonjača, Zlatko; Ravlić-Gulan, Jagoda; Ćuk, Mira; Varljen, Jadranka; Rukavina, Daniel

Croatica Chemica Acta - 68 559-567

Znanstvene knjige

2012.

Priručnik za seminare i vježbe iz medicinske kemije i biokemije I( Medical Chemistry and Biochemistry I Course Handbook )

Rupčić, Jasminka; Domitrović, Robert; Milin, Čedomila; Tota, Marin; Broznić, Dalibor

Medicinski fakultet Sveučilišta u Rijeci, Zavod za kemiju i biokemiju

2012.

Priručnik za seminare i vježbe iz biokemije II( Medical Chemistry and Biochemistry II Course Handbook )

Milin, Čedomila; Domitrović Robert; Tota, Marin; Laginja, Josip; Detel, Dijana; Marinić, Jelena; Varljen, Jadranka; Rupčić, Jasminka

Medicinski fakultet Sveučilišta u Rijeci, Zavod za kemiju i biokemiju

2011.

Harpers Illustrated Biochemistry

Autori prijevoda: Nicoletta Burger, Ivančica Delaš, Robert Domitrović, Irena Drmić Hofman, Blaženka Foretić, Ljubica Glavaš-Obrovac, Nikola Habuzin, Svjetlana Kalanj Bognar, Jasna Lovrić, Jelena Marinić, Anita Markotić, Milan Mesić, Čedomila Milin, Daria Pašalić, Maja Pavela-Vrančič, Jasminka Rupčić, Jadranka Sertić, Marin Tota, Jadranka Varljen, Željka Vukelić

Medicinska naklada

2010.

Priručnik za predavanja i vježbe iz laboratorijske dijagnostike

Domitrović, Robert; Milin, Čedomila; Tota, Marin; Laginja, Josip; Varljen, Jadranka; Rupčić, Jasminka

Fintrade & tours

2010.

Priručnik za vježbe iz biokemije za studente preddiplomskog studija dentalne medicine( Biochemistry - Course Handbook )

Detel, Dijana; Varljen Jadranka; Tota, Marin; Marinić Jelena; Laginja, Josip; Domitrović, Robert; Rupčić, Jasminka, Čedomila, Milin

Medicinski fakultet Sveučilišta u Rijeci

2009.

Priručnik za vježbe iz biokemije za stručni studij Medicinsko-laboratorijske dijagnostike( Biochemistry - Course Handbook )

Čanadi Jurešić, Gordana; Varljen, Jadranka; Milin, Čedomila; Domitrović Robert; Tota, Marin; Rupčić, Jasminka

Medicinski fakultet Sveučilišta u Rijeci

2007.

Priručnik za seminare i vježbe iz biokemije II( Medical Chemistry and Biochemistry II Course Handbook )

Milin, Čedomila; Domitrović Robert; Tota, Marin; Laginja, Josip; Detel, Dijana; Varljen, Jadranka; Rupčić, Jasminka

Medicinski fakultet Sveučilišta u Rijeci

2004.

Priručnik za seminare i vježbe iz biokemije za studente opće medicine

Milin, Čedomila; Domitrović, Robert; Tota, Marin; Laginja, Josip; Detel, Dijana; Varljen, Jadranka; Rupčić, Jasminka

Medicinski fakultet Sveučilišta u Rijeci, Zavod za kemiju i biokemiju

Pozvana predavanja

01-04.06.2016.

Role of ERK MAPK in the regulation of cisplatin-induced toxicity

Domitrović, Robert

Split, Hrvatska

01-04.10.2015.

Steatoza jetre i metabolički sindrom: mehanizam terapijskog djelovanja fitokemikalija

Domitrović, Robert; Potočnjak, Iva; Marinić, Jelena

Lovran, Hrvatska

07-10.10.2010.

Hepatotoksičnost lijekova i ksenobiotika: prevencija i terapija

Domitrović, Robert

Teslić, Bosna i Hercegovina

Kongresna priopćenja

2023.

Proteins in urine - Possible biomarkers of endometriosis

Višnić, Alenka; Čanadi Jurešić, Gordana; Domitrović, Robert; Klarić, Marko; Sušanj Šepić, Tina; Barišić, Dubravko

Pozvano predavanje

2nd International Conference on Women's Health, Gynecology and Polycystic Ovary Syndrome London, Ujedinjeno Kraljevstvo

2022.

Involvement of ERK MAPK signaling pathway in cisplatininduced mitophagy and autophagic cell stress in renal tubular epithelial cells

Potočnjak, Iva; Vukelić, Iva; Šimić, Lidija; Domitrović, Robert

Poster

IUBMB-FEBS-PABMB 2022 Lisabon, Portugal

2022.

Oleanolic acid induces cytoprotective mitophagy in HCT116 human colon carcinoma cells

Šimić, Lidija; Potočnjak, Iva; Vukelić, Iva; Batičić, Lara; Domitrović, Robert

Poster

IUBMB-FEBS-PABMB 2022 Lisabon, Portugal

2021.

Antitumour activity of luteolin in human colon cancer SW620 cells is mediated by the ERK/FOXO3a signalling pathway

Šimić, Lidija; Potočnjak, Iva; Gobin, Ivana; Vukelić, Iva; Domitrović, Robert

Poster

6th Croatian Congress of Toxicology CROTOX 2021 Rabac

2021.

Aucubin administered by either oral or parenteral route protects against cisplatin-induced acute kidney injury in mice.

Potočnjak, Iva; Marinić, Jelena; Batičić, Lara; Šimić, Lidija; Broznić, Dalibor; Domitrović, Robert

Poster

6th Croatian Congress of Toxicology CROTOX 2021. Rabac

2021.

Oleanolic acid induces mitophagy and chemosenzitises human colon carcinoma cells

Potočnjak, Iva; Šimić, Lidija; Vukelić, Iva; Batičić, Lara; Domitrović, Robert

Poster

iochemical Insights into Molecular Mechanisms Kragujevac, Srbija

2021.

Luteolin ameliorates experimental colitis in mice through ERK-mediated suppression of inflammation, apoptosis and autophagy

Vukelić, Iva; Detel, Dijana; Batičić, Lara; Potočnjak, Iva; Domitrović, Robert.

Poster

Biochemical Insights into Molecular Mechanisms Kragujevac, Srbija

2021.

Aucubin administered by either oral or parenteral route protects against cisplatin-induced acute kidney injury in mice

Potočnjak, Iva; Marinić, Jelena; Šimić, Lidija; Broznić, Dalibor; Domitrović, Robert

Poster

The 45th FEBS Virtual Congress Ljubljana, Slovenija

2019.

Oleanolic acid attenuates cisplatin-induced nephrotoxicity in mice and chemosensitizes human cancer cells to cisplatin cytotoxicity

Potočnjak, Iva; Šimić, Lidija; Vukelić, Iva; Domitrović, Robert

Predavanje

Alpe-Adria Rectors Conference (AARC) – International PhD Scientific Conference „Innovative technologies in biomedicine“ Rijeka

2019.

Chlorogenic acid ameliorates experimental colitis in mice by suppressing signaling pathways involved in inflammatory response and apoptosis

Vukelić, Iva; Detel, Dijana; Batičić, Lara; Potočnjak, Iva; Buljević, Sunčica; Domitrović, Robert

Predavanje

Alpe-Adria Rectors Conference (AARC) – International PhD Scientific Conference „Innovative technologies in biomedicine“ Rijeka

2019.

Oleanolic acid attenuates cisplatin-induced nephrotoxicity in mice and chemosensitizes human cervical cancer cells to cisplatin cytotoxicity

Potočnjak, Iva; Šimić, Lidija; Vukelić, Iva; Domitrović, Robert.

Poster

HDBMB2019 Crossroads in Life Sciences Lovran

2018.

Delphinidin aggravates cisplatin-induced nephrotoxicity by augmenting renal oxidative stress, inflammation, and apoptosis

Potočnjak, Iva; Vukelić, Iva; Marinić, Jelena; Škoda, Marko; Domitrović, Robert

poster

FEBS3+ conference ‘From molecules to living systems’ Siófok, Mađarska

2017.

Carvacrol protects human cervical cancer cells against cisplatin- induced cytotoxicity through multiple ERK-dependent mechanisms

Potočnjak, Iva; Gobin, Ivana; Domitrović, Robert

poster

25th Croatian Meeting of Chemists and Chemical Engineers with international participation, 3rd symposium “Vladimir Prelog” Poreč, Hrvatska

2016.

Hippocampal expression of cytokines, metallothionein I/II and glycoprotein 96 in animal models of multiple sclerosis: Impact on adult neurogenesis

Grubić Kezele, Tanja; Blagojević Zagorac, Gordana; Jakovac, Hrvoje; Domitrović, Robert; Radošević-Stašić, Biserka

poster

10th International Congress on Autoimmunity Leipzig, Njemačka

2016.

Carvacrol attenuates acute kidney injury induced by cisplatin through suppression of MAPK and PI3K/Akt pathways

Potočnjak, Iva; Domitrović, Robert; Gobin, Ivana

poster

16th International Conference of Biochemistry and Molecular Biology Vancouver, Kanada

2015.

Oleuropein ameliorates cisplatin-induced oxidative damage, inflammation and apoptosis in mice kidneys by modulating CYP2E1, NF-?B and ERK1/2 expression

Domitrović, Robert; Potočnjak, Iva; Škoda, Marko; Pavletić, Martina

poster

FEBS3+ Meeting Portorož, Slovenija

2014.

Hippocampal expression of metallothioneins I+II, gp96 and cytokines in rat strains with different susceptibility to experimental autoimmune encephalomyelitis

Grubić-Kezele, Tanja; Blagojević Zagorac, Gordana; Jakovac, Hrvoje; Domitrović, Robert; Radošević-Stašić, Biserka

poster

Godišnji skup Hrvatskog imunološkog društva Krk, Hrvatska

2014.

Nephroprotective effect of alkaloid berberine against cisplatin-induced kidney damage in mice

Domitrović, Robert; Gobin, Ivana; Cvijanović, Olga; Pernjak-Pugel, Ester; Škoda, Marko; Mikelić, Lorena

poster

3rd Biotechnology World Congress Dubai, Ujedinjeni Arapski Emirati

2014.

Micromeria croatica ethanolic extract reduces inflammation, oxidative stress and fibrosis in ccl4-induced mouse liver injury

Vladimir-Knežević, Sanda; Cvijanović, Olga; Blažeković, Biljana; Kindl, Marija; Bival Štefan, Maja; Domitrović, Robert

poster

14th International Conference on Oxidative Stress Reduction, Redox States & Antioxidants Pariz, Francuska

2013.

Hepatic metallothioneins I+II, gp96, IL-6 and TGF-beta as potential regulators of strain-dependent susceptibility to experimental autoimmune encephalomyelitis in rats

Grubić-Kezele, Tanja; Blagojević Zagorac, Gordana; Jakovac, Hrvoje; Domitrović, Robert; Radošević-Stašić, Biserka

oralno

2nd Meeting of Middle-European Societies for Immunology and Allergology Opatija, Hrvatska

2012.

Differential hepatoprotective mechanisms of rutin and quercetin in carbon tetrachloride-intoxicated BALB/cN mice

Šain, Ivana; Jakovac, Hrvoje; Vasiljev Marchesi, Vanja; Vladimir-Knežević, Sanda; Cvijanović, Olga; Tadić, Žarko; Domitrović, Robert

poster

FEBS 3+ Meeting Opatija, Hrvatska

2012.

Preventive and therapeutic effects of oleuropein against carbon tetrachloride-induced liver damage in mice

Šain, Ivana; Jakovac, Hrvoje; Vasiljev Marchesi, Vanja; Domitrović, Robert

poster

FEBS 3+ Meeting Opatija, Hrvatska

2010.

Terapijski učinak ekstrakta korijena maslačka (Taraxacum officinale Weber) u fibrozi jetre u miševa.( Therapeutic effect of dandelion (Taraxacum officinale Weber) root extract in liver fibrosis in mice )

Tadić, Žarko; Šain, Ivana; Staver, Mihaela; Jakovac, Hrvoje; Domitrović, Robert

poster

Prvi studentski kongres Prehrana i klinička dijetoterapija Rijeka, Hrvatska

2010.

Antifibrotic activity of anthocyanidin delphinidin in carbon tetrachloride-induced hepatotoxicity in mice

Domitrović, Robert; Jakovac, Hrvoje

poster

10th Congress of the Croatian Society of Biochemistry and Molecular Biology with International Participation Opatija, Hrvatska

2010.

Liver fibrosis in mice induced by carbon tetrachloride and its reversion by luteolin

Domitrović, Robert; Jakovac, Hrvoje; Tomac, Jelena; Šain, Ivana; Tadić, Žarko

poster

10th Congress of the Croatian Society of Biochemistry and Molecular Biology with International Participation - HDBMB2010 Opatija, Hrvatska

2009.

Dose- and time-dependent effects of luteolin on heat shock protein gp96 expression in carbon tetrachloride-induced hepatotoxicity in mice

Domitrović, Robert; Jakovac, Hrvoje; Radošević-Stašić, Biserka; Milin, Čedomila

poster

Third SMBBM International Congress of Biochemistry, IUBMB Special Meeting on plant stresses & 6 th Congress of FASBMB Marrakech, Maroko

2008.

Dose- and time-dependent effects of luteolin on liver metallothioneins and metals in carbon tetrachloride-induced hepatotoxicity in mice

Domitrović, Robert; Jakovac, Hrvoje; Grebić, Damir; Milin, Čedomila; Radošević-Stašić, Biserka

poster

HDBMB2008, Congress of the Croatian Society of Biochemistry and Molecular Biology with international participation Osijek, Hrvatska

2008.

Utjecaj prehrane preopterećene željezom i obogaćene maslinovim i kukuruznim uljem na koncentraciju tokoferola i retinola kod miševa

Milin Čedomila; Tota Marin; Domitrović Robert

poster

20th International Congress of Clinical Chemistry and Laboratory Medicine Fortaleza, Brazil

2008.

Dose- and time-dependent effects of luteolin in carbon tetrachloride-induced hepatotoxicity in mice

Domitrović, Robert; Jakovac, Hrvoje; Grebić, Damir; Milin, Čedomila; Radošević-Stašić, Biserka

poster

ComBio2008 Canberra, Australija,

2006.

Oxidative stress in mice: effects of dietary corn oil and iron

Domitrović, Robert; Tota, Marin; Hachem, Amira; Taslak, Jelena; Zavidić, Tina; Milin, Čedomila

poster

5. Hrvatski kongres medicinskih biokemičara s međunarodnim sudjelovanjem Poreč, Hrvatska

2005.

Metal tissue kinetics in regenerating liver, thymus, spleen and submandibular gland after partial hepatectomy in mice

Milin, Čedomila; Tota, Marin; Domitrović, Robert; Ćuk, Mira; Mrakovčić-Šutić, Ines; Jakovac, Hrvoje; Grebić, Damir; Radošević-Stašić, Biserka

poster

2nd World Congress on Regenerative Medicine Leipzig, Njemačka

2004.

Olive and corn-oil enriched diets as modulators of tissue mineral content in the submandibular gland of partially hepatectomized mice

Milin, Čedomila; Tota, Marin; Domitrović, Robert; Pantović, Radojka; Giacometti, Jasminka; Ćuk, Mira; Mrakovčić-Šutić, Ines; Jakovac, Hrvoje; Radošević-Stašić, Biserka

poster

Congress of the Croatian Society of Biochemistry and Molecular Biology Bjelolasica, Hrvatska

2004.

Effects of dietary fats (olive and corn oils) on hepatic antioxidant status and lipid peroxidation in iron-overloaded Balb/c mice

Domitrović, Robert; Tota, Marin; Milin, Čedomila

poster

Congress of the Croatian Society of Biochemistry and Molecular Biology Bjelolasica, Hrvatska

2004.

Changes in Liver Regeneration and Tissue Mineral Content in Liver and Lymphatic Organs after Olive and Corn-oil Enriched Diet

Milin, Čedomila; Tota, Marin; Giacometti, Jasminka; Domitrović, Robert; Pantović, Radojka; Ćuk, Mira; Radošević-Stašić, Biserka

poster

12th International Biotechnology Symposium and Exhibition (Biotechnology 2004) Santiago, Čile

2004.

Olive and corn-oil enriched diets as modulators of liver regeneration and tissue mineral content in the remnant liver and lymphatic organs

Milin, Čedomila; Tota, Marin; Giacometti, Jasminka; Domitrović, Robert; Pantović, Radojka; Mrakovčić-Šutić, Ines; Ćuk, Mira; Radošević-Stašić, Biserka

poster

7th International Symposium on Predictive Oncology and Intervention Strategies Nica, Francuska

2003.

Effects of olive and corn-oil enriched diets on tissue mineral content in regeneration liver and lymphatic tissue of partially hepatectomized mice

Tota, Marin; Milin, Čedomila; Giacometti, Jasminka; Domitrović, Robert; Pantović, Radojka; Ćuk, Mira; Radošević-Stašić, Biserka

poster

Annual Meeting of the Croatian Immunological Society Brijuni, Hrvatska

2002.

Hepatic mineral content during liver regeneration in conditions of plant oil-enriched diets

Milin, Čedomila; Domitrović, Robert; Tota Marin; Ćuk, Mira; Radošević-Stašić, Biserka

poster

The 18th International Congress of Clinical Chemistry and Laboratory Medicine Kyoto, Japan

2001.

Effect of plant oil enriched diets on the mineral concentration in mice during liver regeneration

Milin, Čedomila; Domitrović, Robert; Tota, Marin; Ćuk, Mira; Radošević-Stašić, Biserka; Ciganj, Zlatko

poster

14th IFCC-FESCC European Congress of Clinical Chemistry and Laboratory Medicine Prague, Czech Republic

2001.

Dietary fats and tissue mineral concentration in the early phase of liver regeneration

Milin, Čedomila; Domitrović, Robert; Tota, Marin; Ćuk, Mira; Radošević-Stašić, Biserka; Ciganj, Zlatko

poster

III. Hrvatski kongres farmakologije s međunarodnim sudjelovanjem Zagreb, Hrvatska

2000.

Effect of olive oil and corn oil enriched diets on the tissue mineral content

Milin, Čedomila; Domitrović, Robert; Tota, Marin; Giacometti, Jasminka; Ćuk, Mira; Radošević-Stašić, Biserka; Laginja, Josip

poster

6th Alps-Adria Congress of Clinical Chemistry and Laboratory Medicine Opatija, Hrvatska

2000.

Effect of different diet conditions on the liver mineral content in compensatory liver growth

Milin, Čedomila; Domitrović, Robert; Tota, Marin; Giacometti, Jasminka; Ćuk, Mira; Radošević-Stašić, Biserka

poster

Silver jubilee meeting of the Croatian Biochemical Society Zagreb, Hrvatska

1999.

Cink i cink-vezujući enzimi tijekom ranog perioda kompenzacijskog rasta jetre (Zinc and zinc-binding proteins during early phase of compensatory liver growth)

Domitrović, Robert; Milin, Čedomila; Verbanac, Donatella; Stašić-Radošević, Biserka

poster

Treći kongres hrvatskih medicinskih biokemičara s međunarodnim sudjelovanjem Vukovar, Hrvatska

1999.

The metals in early compensatory liver growth (after olive oil administration)

Tota, Marin; Milin, Čedomila; Domitrović, Robert; Giacometti, Jasminka; Pantović, Radojka; Radošević-Stašić, Biserka; Ćuk, Mira

poster

1st FEBS Advanced Course on Glycoconjugates - versatile structures and intriguing functions. Lovran, Hrvatska

07.05.1998.

Zinc and zinc-binding proteins during compensatory liver growth in mice

Domitrović, Robert; Verbanac, Donatella; Mocchegiani, Eugenio; Pantović, Radojka; Radošević-Stašić, Biserka; Milin, Čedomila

poster

Silver Jubilee FEBS Meeting Kopenhagen, Danska

07.07.1996.

Activation of zinc-dependent hepato-thymic axis during the liver regeneration in hepatectomized mice

Milin, Čedomila; Radošević-Stašić, Biserka; Verbanac, Donatella; Domitrović, Robert; Pantović, Radojka; Petković, Marija; Ćuk, Mira; Trobonjača, Zlatko

poster

24th Meeting of FEBS Barcelona, Španjolska

1995.

Koncentracija cinka u različitim organima tijekom inducirane HvG reakcije (Zinc concentration in different organs during induced HvG reaction)

Verbanac, Donatella; Milin, Čedomila; Domitrović, Robert; Giacometti, Jasminka; Pantović, Radojka; Varljen, Jadranka; Montana, Vedrana; Laginja, Josip; Radošević-Stašić, Biserka

poster

Međunarodni simpozij medicinskih biokemičara Hrvatske i Slovenije Krk, Hrvatska

1995.

Tissue zinc dynamic during the immune response in mice

Verbanac, Donatella; Milin, Čedomila; Domitrović, Robert; Giacometti, Jasminka; Ciganj, Zlatko; Petković, Marija; Ćuk, Mira; Muhvić, Damir; Radošević-Stašić, Biserka

poster

Annual Meeting of Croatian Biochemists with international participation Supetar na Braču, Hrvatska

1994.

The role of zinc in liver regeneration

Milin, Čedomila; Verbanac, Donatella; Domitrović, Robert; Petković, Marija; Ćuk, Mira; Varljen, Jadranka; Radošević-Stašić, Biserka

poster

Annual Meeting of Croatian Biochemists Opatija, Hrvatska

1993.

Correction of hepatotoxic and immunosuppressive effects of halothane anaesthesia by peptidoglycan-monomer (PGM) and its analogues.

Milin, Čedomila; Verbanac, Donatella; Domitrović, Robert; Giacometti, Jasminka; Trobonjača, Zlatko; Ćuk, Mira; Radošević-Stašić, Biserka

poster

Annual Meeting of Croatian Biochemists with International Participation Zagreb, Hrvatska

19-22.04.2017.

Carvacrol protects human cervical cancer cells against cisplatin- induced cytotoxicity through multiple ERK-dependent mechanisms

Potočnjak, Iva; Gobin, Ivana; Domitrović, Robert

poster

5th Croatian Meeting of Chemists and Chemical Engineers with international participation, 3rd symposium “Vladimir Prelog” Poreč

Mentorstvo doktorandima

2020.

Antitumorski i kemosenzitizirajući učinak oleanolične i betulinske kiseline na stanice raka debelog crijeva

Lidija Šimić Ševerdija Doktorat

Biomedicina

Medicinski fakultet

2014. - 2020.

Mehanizmi djelovanja fitokemikalija kod akutnog oštećenja bubrega cisplatinom u miševa.

Potočnjak, Iva Doktorat

Zdravstveno-ekološko inženjerstvo

Medicinski fakultet

Datum obrane: 13.02.2020.

2004. - 2007.

Antioksidacijski pokazatelji preopterećenosti željezom u uvjetima prehrane obogaćene biljnim uljima

Tota, Marin Doktorat

Biomedicina

Medicinski fakultet

Datum obrane: 15.06.2007.

Uredništva časopisa

2006. - 2011.

Biochemia Medica

Recenzije

2018.

Jiang-Zhi granules decrease sensitivity to low-dose CCL4 induced liver injury in NAFLD rats through reducing endoplasmic reticulum stress. BMC Complementary and Alternative Medicine

2017.

Chlorogenic acid attenuates acetaminophen-induced hepatotoxicity by activating Keap1-Nrf2 pathway and the involvement of ERK1/2. Biochemical Pharmacology

2017.

Precocious obesity predisposes the development of more severe cisplatin-induced acute kidney injury in young adult mice. PLOS ONE

2017.

Magnesium attenuates cisplatin-induced nephrotoxicity by regulating the expression of renal transporters. European Journal of Pharmacology

2016.

Valproate induced hepatic steatosis by enhanced fatty acid uptake and triglyceride synthesis. Biochemical Pharmacology

2016.

Effectiveness of Traditional Chinese Medicine on endotoxemia in patients with acute-on-chronic and chronic liver failure: a multicenter randomized controlled trial. BMC Infectious Diseases

2016.

Rosmarinic acid protects against myocardial ischemia/reperfusion injury by activating peroxisome proliferator-activated receptor gamma. Journal of Cellular and Molecular Medicine

2016.

Effect of Nigella sativa ground seeds supplementaion in diet on fatty liver disease in rats. BMC Complementary and Alternative Medicine

2016.

Gastroprotective and ulcer healing effects of hydroethanolic extract of leaves of Caryocar coriaceum: mechanisms involved in the gastroprotective activity. Chemico-Biological Interactions

2016.

The role of Nrf2 activation in protection effect of chlorogenic acid on acute liver injury induced by CCl4. Chemico-Biological Interactions

2016.

Dimethyl ?-ketoglutarate reduces CCl4-induced liver fibrosis through inhibition of autophagy in hepatic stellate cell . Toxicology and Applied Pharmacology

2016.

Anthocyanidins inhibit epithelial-mesenchymal transition through a TGF-ß/Smad2 signaling pathway in glioblastoma cells. Molecular Carcinogenesis

2016.

Hepatoprotective effects of polymethoxyflavones against acute and chronic carbon tetrachloride intoxication. Food and Chemical Toxicology

2016.

The antifibrotic and fibrolytic properties of date fruit extract via modulation of genotoxicity, tissue-inhibitor of metalloproteinases and nuclear factor- kappa B pathway in a rat model of hepatotoxicity. BMC Complementary and Alternative Medicine

2016.

Protective effects of Fraxinus xanthoxyloides (Wall.) leaves against CCl4 induced hepatic toxicity in rat. BMC Complementary and Alternative Medicine

2016.

Hepatoprotective and antioxidant potential of Asphodeline lutea (L.) Rchb. roots extract in experimental models in vitro/in vivo. RCS Advances

2016.

Inflammation, oxidative stress and apoptosis cascade implication in Bisphenol A-induced liver fibrosis in male rats. Food and Chemical Toxicology

2016.

Modulating the JAK/STAT pathway by ruxolitinib ameliorates thioacetamide-induced hepatotoxicity. Food and Chemical Toxicology

2016.

Activation of proinflammatory signaling by 4-hydroxynonenal-Src adducts in aged kidneys. Oncotarget

2016.

Magnolia officinalis (Hou Po) bark extract stimulates the Nrf2-pathway in hepatocytes and protects against oxidative stress. Journal of Ethnopharmacology

2016.

Impairment of Akt activity by CYP2E1 mediated oxidative stress is involved in chronic ethanol-induced fatty liver. Biochemical Pharmacology

2016.

Effects of Vernonia cinerae Less. Extracts on catecholamine, oxidative stress and chromosome aberration in nicotine-treated rats. BMC Complementary and Alternative Medicine

2015.

Hepatoprotective effects of polymethoxyflavones against acute and chronic carbon tetrachloride intoxication. Food and Chemical Toxicology

2015.

Protective effects of Ginsenoside Rg1 against carbon tetrachloride-induced liver injury in mice through suppression of inflammation. Phytomedicine

2015.

The antifibrotic and fibrolytic properties of date (Phoenix dactylifera L.) fruit extract via attenuation of genotoxicity, downregulation of tissue-inhibitor of matrix metalloproteinases and suppression of nuclear factor- kappa B pathway in carbon tetrachloride-induced hepatotoxicity in rats. BMC Complementary and Alternative Medicine

2015.

The olive leaf extract oleuropein exerts protective effects against oxidant-induced cell death, concurrently displaying pro-oxidant activity in human hepatocarcinoma cells. Redox Report

2015.

Thymoquinone ameliorates acute renal failure in gentamicin-treated adult male rats. Drug Design, Development and Therapy

2015.

Myricetin ameliorates the symptoms of collagen-induced arthritis in mice by inhibiting cathepsin K activity. Immunopharmacology and Immunotoxicology

2015.

Non preventive role of aerobic exercise against CP-induced nephrotoxicity in female rats. International Journal of Preventive Medicine

2015.

Lysimachia christinae Hance regresses preestablished cholesterol gallstone in mice. Journal of Etnopharmacology

2015.

Berberine-loaded solid lipid nanoparticles are concentrated in the liver and ameliorate hepatosteatosis in db/db mice. International Journal of Nanomedicine

2014.

The renoprotective effects of berberine via the EP4-G?s-cAMP signaling pathway in different stages of diabetes in rats. Journal of Diabetes and its Complications

2014.

Loureirin B attenuates the extracellular matrix deposition and the aberrant proliferation of fibroblasts during hypertrophic scar formation. Biochemical Pharmacology

2014.

Characterization of renal biomarkers for use in clinical trials: effect of preanalytical processing and qualification using samples from subjects with diabetes. Drug Design, Development and Therapy

2014.

Protective mechanisms of medicinal plants targeting hepatic stellate cell activation and extracellular matrix deposition in liver fibrosis. Chinese Medicine

2014.

Paeoniflorin exerts nephroprotective effect against concanavalin A (conA)-induced renal damage through inhibiting macrophage infiltration. Plos ONE

2014.

Tempol, a superoxide dismutase mimetic agent, ameliorates cisplatin-induced nephrotoxicity through alleviation of mitochondrial dysfunction in mice. Plos ONE

2014.

Manganese supplementation decreases reactive oxygen species by reducing iron levels in liver tissue of Zucker diabetic rats. Biological Trace Element Research

2014.

Hepatoprotective and antioxidative effects of Lygodium microphyllum (Cav.) R.Br. against carbon tetrachloride (CCl4)-mediated oxidative hepatic injury in rats. Journal of Pharmacy and Pharmacology

2014.

Comparison of hepatoprotective effect of chokeberry juice and silymarin in rats treated chronically with carbon tetrachloride. Journal of Pharmacy and Pharmacology

2014.

Paraoxonase 1 activity and phenotype distribution in premenopausal and postmenopausal women. Biochemia Medica

2014.

Sesamol loaded solid lipid nanoparticles: a promising intervention for control of carbon tetrachloride induced hepatotoxicity. Food and Chemical Toxicology

2014.

Mistletoe alkaloid fractions alleviates carbon tetrachloride-induced liver fibrosis through inhibition of hepatic stellate cell activation via TGF-ß/Smad interference. Journal of Etnopharmacology

2014.

Concentrated green tea extract induces severe acute hepatitis in a 63-year-old woman - a case report with pharmaceutical analysis. Journal of Ethnopharmacology

2014.

Silymarin inhibits the progression of fibrosis in the early stages of liver injury in CCl4-treated rats. Journal of Medicinal Food

2014.

Berberine improves pressure overload-induced cardiac hypertrophy and dysfunction through enhanced autophagy. European Journal of Pharmacology

2014.

Evaluation of toxicity of Calophyllum brasiliense stem bark extract by in vivo and in vitro assays. Journal of Etnopharmacology

2014.

Can pharmacological targeting of advanced glycation end products provide protection against experimentally induced liver fibrosis? Biochemical Pharmacology

2014.

CXCL12 induces connective tissue growth factor expression in human lung fibroblasts through the Rac1/ERK/AP-1 pathway. Biochemical Pharmacology

2013.

Blockade of CCN4 attenuates CCl4-induced liver fibrosis. Immunological Investigations

2013.

Berberine induces apoptosis in p53-null leukemia 1 cells by down-regulating XIAP at the post-transcriptional level. Cellular Physiology and Biochemistry

2013.

Terminalia arjuna bark extract inhibits histological alterations by mitigating oxidative stress in lead intoxicated mice. Oriental Pharmacy and Experimental Medicine

2013.

Clinico-epidemiological features of poisoned patients in Emergency Department – a two and half year’s single hospital experience. International Journal of Critical Illness and Injury Science

2013.

Hepatoprotective Effect of Manganese Chloride Against CCl4-Induced Liver Injury in Rats. Biological Trace Element Research

2013.

Arylbenzofuran isolated from Dalbergia odorifera suppresses lipopolysaccharide-induced mouse BV2 microglial cell activation, which protects mouse hippocampal HT22 cells death from neuroinflammation-mediated toxicity. European Journal of Pharmacology

2013.

Delphinidin suppresses PMA-induced MMP-9 expression by blocking the NF-?B activation via MAPK signaling pathways in MCF-7 human breast carcinoma cells. European Journal of Pharmacology

2013.

Nitidine chloride induces apoptosis and inhibits tumor cell proliferation via suppressing ERK signaling pathway in renal cancer. Food and Chemical Toxicology

2013.

Characteristics of albumin binding sites in patients and chernobyl clean-up workers with type 2 diabetes mellitus. Journal of Experimental and Integrative Medicine

2013.

The influence of short term food deprivation on calcium, magnesium, zinc, and copper status in healthy women. Biological Trace Element Research

2013.

Carthamus Red from Carthamus tinctorius exerts antioxidant and hepatoprotective effect against CCl4-induced liver damage in rats via the Nrf2 pathway. Food and Chemical Toxicology

2013.

Chlorogenic acid prevents tetrachlorobenzoquinone induced acute liver injury in mice. Food and Chemical Toxicology

2013.

Anti-hepatofibrotic effects and its mechanisms of an herbal medicine (CGX) in an alcohol-fed rat model. Food and Chemical Toxicology

2013.

Prevalence of nitrite and nitrate contents and its effect on edible bird nest's colour. Journal of Etnopharmacology

2013.

Study on the correlation between constituents detected in serum from Rhizoma Smilacis Glabrae and the reduction of uric acid levels in hyperuricemia. Journal of Ethnopharmacology

2013.

Protective effect of A.ferrugineaDC. against Ulcerative colitis via modulating inflammatory mediators, cytokine profile and NF-?Bsignal transduction pathways. Journal of Ethnopharmacology

2013.

Effect of Ocimum basilicum L. on cyclo-oxygenase isoforms and prostaglandins involved in thrombosis. Journal of Ethnopharmacology

2013.

Protective effect of standardized extract of Ginkgo biloba against cisplatin-induced nephrotoxicity. Evidence-Based Complementary and Alternative Medicine

2013.

Antifibrotic effects of luteolin on hepatic stellate cells and liver fibrosis by targeting Akt/mTOR/p70S6K and TGFß/Smad signaling pathways. Biochemical Pharmacology

2012.

Oleuropein prevents ethanol-induced gastric ulcers via elevation of antioxidant enzyme activities in rats. Journal of Physiology and Biochemsitry

2012.

Determination of copper at extended dose levels and pharmacokinetics studies of copper (II)-acetylsalicylate: A safe prodrug of aspirin. Biological Trace Element Research

2012.

Histoarchitectural and biochemical alterations under stress of type II pyrethroids in rat liver. Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology

2012.

Hepatoprotective activity of Chenopodium album Linn: in vitro and in vivo studies. Journal of Experimental and Integrative Medicine

2012.

Hepatoprotective activity of extracted anthocyanins fraction of red radish (Raphanus sativus L) on albino rats. Journal of Experimental and Integrative Medicine

2012.

Polyuria following an overdose. International Journal of Critical Illness and Injury Science

2012.

Haematological parameters of Wistar rats sub-chronically exposed to aqueous extract of Arrabidaea chica (Bonpl.) B. Verl. Journal of Ethnopharmacology

2012.

Methyl helicterate protects against CCl4-induced liver injury in rats by inhibiting oxidative stress, NF-?B activation, Fas/FasL pathway and cytochrome P4502E1 level. Food and Chemical Toxicology

2012.

Effect of Bathysa cuspidata extract in recovering the morphofunctional damage of the liver parenchyma after carbon tetrachloride intoxication. Food and Chemical Toxiclogy

2012.

Time-dependent hormetic effects of 1-alkyl-3-methylimidazolium bromide on Vibrio qinghaiensis sp.-Q67: luminescence, redox reactants and antioxidases. Chemosphere

2012.

Cerium chloride improves protein and carbohydrate metabolism of fifth-instar larvae of Bombyx mori under phoxim toxicity. Biological Trace Element Research

2012.

The influence of short term food deprivation on calcium, magnesium, zinc, and copper status in healthy women. Biological Trace Element Research

2012.

Protective effect of Fufang-Liu-Yue-Qing, a traditional Chinese herbal formula, on CCl4 induced liver fibrosis in rats. Journal of Etnopharmacology

2012.

Studies of biological properties of Uncaria tomentosa extracts on human blood mononuclear cells. Journal of Ethnopharmacology

2012.

Chronic toxicity of ginsenoside Re on Sprague-Dawley rats. Journal of Etnopharmacology

2012.

Shikonin ameliorates cerulein-induced acute pancreatitis in mice. Journal of Ethnopharmacology

2012.

Antipropulsive and cytotoxic properties of incomptines A and B from Decachaeta incompta (DC) King & Robinson. Journal of Ethnopharmacology

2012.

Peking spurge and liquorice root augment rhodamine123 intestinal absorption: incompatibility pairs and the role of p-glycoprotein. Journal of Ethnopharmacology

2012.

The ethyl acetate fraction of Polytrichum commune L.ex Hedw induced cell apoptosis via reactive oxygen species in L1210 cells. Journal of Ethnopharmacology

2011.

Zingiber officinale acts as a nutraceutical agent against liver fibrosis induced by carbon tetrachloride in rats. Europeian Journal of Medicinal Chemistry

2011.

Camel's milk alleviates alcohol-induced liver injury in rats. Food and Chemical Toxicology

2011.

Ellagic acid ameliorates lung injury after intestinal ischemia-reperfusion. Pharmacognosy Magazine

2011.

Oxidative stress measured by carbonyl groups level in postmenopausal women after oral and transdermal hormone therapy. Biochemia Medica

2010.

Therapeutic effects of SMND-309, a new metabolite of salvianolic acid B, on experimental liver fibrosis. Europeian Journal of Pharmacology

2010.

Inhibitory effect of Dioscorea panthaica on CCl4-induced liver fibrosis in rats. Pharmacognosy Magazine

2010.

Laboratory medicine education in Lithuania. Biochemia Medica

2010.

Toxic Effects of Copper(II) Sulphate Pentahydrate on Liver Histopathology and Proteins in Adult Mice (Mus musculus). Biological Trace Element Research

2010.

Antihyperglycemic and antihyperlipidemic effects of guar gum in Streptozotocin-induced diabetes male rats. Pharmacognosy Magazine

2010.

Hepatoprotective effects of select water soluble PARP inhibitors in a carbon tetrachloride model. International Journal of Critical Illness and Injury Science

2010.

Protective effects of Wu-Ling-Shen (Xylaria nigripes) on carbon tetrachloride-induced hepatotoxicity in mice. Journal of Pharmacy and Pharmacology

2010.

Esculetin ameliorates carbon tetrachloride-mediated hepatic apoptosis in rats. Journal of Pharmacy and Pharmacology

2010.

The toxic effects of nickel chloride on liver, erythropoiesis, and development in Wistar albino preimplanted rats can be reversed with selenium pretreatment. Environmental Toxicology

2009.

Trace Elements and Metallothionein in Liver and Kidney of Felis catus. Biological Trace Element Research

2009.

Long-term effects of high lipid and high energy diet on serum lipid, brain fatty acid composition, and memory and learning ability in mice. International Journal of Developmental Neuroscience

2008.

Chemoprevention against carbon tetrachloride (CCl4) induced hepatotoxicity and genotoxicity by two Organo-selenium compounds in vivo: a comparison. Pharmacological Research

2008.

Effects of Matricaria chamomilla on Elements Status in Ethanol-Induced Gastric Mucosa Injury in Rats. Biological Trace Element Research

2008.

Gender Differences in Correlations Between the Content of Elements in Rain Water and the Frequency of Hospitalization for Arterial Hypertension, Chronic Obstructive Pulmonary Disease and Psoriasis in Opole Voivodship, Poland, During 2000-2002. Biological Trace Element Research

Stručna djelatnost

Stručna aktivnost

2001. - 2015.

Analiza ekotoksičnosti industrijskih otpadnih voda riječkog bazena i poredbena ispitivanja s referentnim uzorcima. Kakvoća vodenog uzorka određuje se prema HRN EN ISO 11348-2:2000 normi

Zavod za kemiju i biokemiju Medicinskog Fakulteta Sveučilišta u Rijeci

analitičar

Javno djelovanje

Popularizacija znanosti

15.01.2012.

članak na internetskom portalu

http://net.hr/magazin/zdravlje/nije-bez-vraga-maslina-u-casi-martinija/

Medijski nastupi

12.03.2016.

intervju za HRT

http://vijesti.hrt.hr/326122/pocela-sezona-sparoga-cijena-prava-sitnica

Projekti

Znanstveni projekti

2018. - 2023.

Interakcija lijekova i fitokemikalija in vitro i in vivo: uloga FOXO signalnog puta

Voditelj projekta

Sveučilište u Rijeci 45.000 kn godišnje

https://spapp.uniri.hr/projekti/ProjectNO1801/Details/1159

2018. - 2023.

Uloga novootkrivenih proteaza u razvoju i progresiji tumora debelog crijeva

Suradnik na projektu

Sveučilište u Rijeci 25.000 kn godišnje

https://pdb.irb.hr/project/irb:006520

2013. - 2018.

Intereakcija fitokemikalija i lijekova in vivo: modulacija nefrotoksičnosti cisplatina

Voditelj projekta

Sveučilište u Rijeci 45.000 kn godišnje

https://portal.uniri.hr/Projects/Details/054?up=true

2008. - 2012.

Aktivni sastojci ljekovitog bilja u terapiji fibroze jetre

Voditelj projekta

MZOS 70000,00 kn godišnje

http://zprojekti.mzos.hr/public/c2prikaz_det.asp?cid=2&ID=3311

2007. - 2012.

Masne kiseline i polifenoli u regeneraciji i reparaciji tkiva

Suradnik na projektu

MZOS

http://zprojekti.mzos.hr/public/c2prikaz_det.asp?cid=1&psid=10&ID=473

2002. - 2005.

Nutritivni učinak biljnih ulja u regeneraciji jetre

Suradnik na projektu

MZOS

http://zprojekti.mzos.hr/zprojektiold/prikaz_det.asp?sort=2&offset=1050&ID=0062002

1996. - 2002.

Cink u kompenzacijskom rastu jetre i imunološkom odgovoru

Suradnik na projektu

MZOS

http://zprojekti.mzos.hr/zProjektiold/arh_det.asp?sort=4&offset=75&ID=529

1993. - 1995.

Uloga cinkovih iona u kompenzacijskom rastu jetre i imunološkim funkcijama

Suradnik na projektu

MZOS

http://www.mzos.hr/svibor/3/01/514/proj_h.htm

Projekti u znanosti - Voditelj projekta

UNIRI PROJEKTI 2018
Potpore 2014/2016

Projekti u znanosti - Suradnik na projektu

UNIRI PROJEKTI 2018
Potpore 2014/2016