Dr.sc Slađana Bursać dipl.san.ing

Medicinski fakultet Katedra za molekularnu medicinu i biotehnologiju
Medicinski fakultet Katedra za molekularnu medicinu i biotehnologiju

mobitel : 091-555-3857
e-pošta : sladana.bursac@uniri.hr
prostorija : Zavod za Molekularnu medicinu i biotehnologiju, Medicinski fakultet Rijeka

MEĐUNARODNA VIDLJIVOST:
CITATIH-INDEXI10-INDEX
CROSBI
google scholar 121 4 3

Obrazovanje

1.1.2007. - 1.1.2013. Doktor znanosti Poslijediplomski studij biomedicina Medicinski fakultet Rijeka
1.1.2000. - 1.1.2004. Diplomirani sanitarni inženjer Diplomski sveučilišni studij sanitarno inženjerstvo Medicinski fakultet Rijeka
1.1.1996. - 1.1.2000. Farmaceutski tehničar Farmaceutski tehničar Medicinska škola Rijeka

Radno iskustvo

1.1.2006. - Poslijedoktorand Sudjelujem u izvođenju vježbi i seminara iz kolegija Molekularna medicina i biotehnologija I i II, preddiplomski sveučilišni studij sanitarnog inženjerstva Medicinski fakultet Rijeka, Zavod za Molekularnu medicinu i biotehnologiju

Nagrade i priznanja

9.12.2014. Nagrada za najbolju mladu znanstvenicu za temeljne medicinske znanosti Medicinskog fakulteta u Rijeci u 2014. godini
14.3.2013. Nagrada “Željko Trgovčević” za najboljeg mladog istraživača u području molekularne biologije za 2012. godinu
6.2.2013. Nacionalna stipendija ”Za žene u znanosti” koju dodjeljuju L'Oreal ADRIA i Ministarstvo kulture (Hrvatsko povjerenstvo za UNESCO) za 2013.godinu

Članstva

1.1.2012. - Hrvatsko društvo za biokemiju i molekularnu medicinu
1.1.2012. - Hrvatsko genetičko društvo

Nastavna djelatnost

Kolegiji

1.1.2013. - Laboratorijske tehnike u molekularnoj medicini
Diplomski sveučilišni studij Medicinsko laboratorijska dijagnostika
Medicinski fakultet Rijeka
suradnik
Norma sati: 15
1.1.2008. - Molekularna medicina i biotehnologija I
Preddiplomski studij sanitarnog inženjerstva
Medicinski fakultet Rijeka
suradnik
Norma sati: 84
1.1.2008. - Molekularna medicina i biotehnologija II
Preddiplomski studij sanitarnog inženjerstva
Medicinski fakultet Rijeka
suradnik
Norma sati: 15

Mentor u završnim radovima

- Karakterizacija monoklonskog protutijela protiv bjelančevine Cdc6
Lalilita Barišić
Preddiplomski sveučilišni studij sanitarnog inženjerstva
Medicinski fakultet Sveučilišta u Rijeci

Znanstvena i umjetnička djelatnost

Znanstveni radovi

1. Bublik, Débora R. ; Bursać, Slađana ; Sheffer, Michal ; Oršolić, Ines ; Shalit, Tali ; Tarcic, Ohad ; Kotler, Eran ; Mouhadeb, Odelia ; Hoffman, Yonit ; Fuchs, Gilad ; Levin, Yishai ; Volarević, Siniša ; Oren, Moshe
Regulatory module involving FGF13, miR-504, and p53 regulates ribosomal biogenesis and supports cancer cell survival
- 2016.
Preuzeto sa: https://bib.irb.hr/prikazi-rad?&rad=856082

2. DR Bublik, S Bursać, M Sheffer, I Oršolić, T Shalit, O Tarcic, E Kotler, O Mouhadeb, Y Hoffman, G Fuchs, Y Levin, S Volarević, M Oren;
Regulatory module involving FGF13, miR-504, and p53 regulates ribosomal biogenesis and supports cancer cell survival.
Proceedings of the National Academy of Sciences - 2016.

3. Kanellis, Dimitris C. ; Bursać, Slađana ; Tsichlis, Philip N. ; Volarević, Siniša ; Eliopoulos, Aristides G. ;
Physical and functional interaction of the TPL2 kinase with Nucleophosmin
Oncogene 34 2516-2526 - 2015.
Preuzeto sa: https://bib.irb.hr/prikazi-rad?&rad=816877

WOS

4. Kanellis, Dimitris C; Bursac, S; Tsichlis, Philip N; Volarevic, S; Eliopoulos, Aristides G;
Physical and functional interaction of the TPL2 kinase with nucleophosmin
Oncogene 34 2516-2526 - 2015.

5. Bursac, Sladana; Brdovcak, Maja Cokaric; Donati, Giulio; Volarevic, Sinisa;
Activation of the tumor suppressor p53 upon impairment of ribosome biogenesis
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1842 817-830 - 2014.

6. Velimezi, Georgia ; Liontos, Michalis ; Roumeliotis, Konstantinos Vougas Theodoros ; Bartkova, Jirina ; Sideridou, Maria ; Dereli-Oz, Ayguel : Kocylowski, Maciej ; Pateras, Ioannis S. ; Evangelou, Kostas ; Kotsinas, Athanassios ; Oršolić, Ines ; Bursać, Slađana ; Cokarić-Brdovčak, Maja ; Zoumpourlis, Vassilis ; Kletsas, Dimitris ; Papafotiou, George ; Klinakis, Apostolos ; Volarević, Siniša ; Gu, Wei ; Bartek, Jiri ; Halazonetis, Thanos D. ; Gorgoulis, Vassilis G.
Functional interplay between the DNA-damage- response kinase ATM and ARF tumour suppressor protein in human cancer
Nature cell biology 15 967-977 - 2013.
Preuzeto sa: https://bib.irb.hr/prikazi-rad?&rad=654793

WOS

7. Bursać, Slađana ; Cokarić Brdovčak, Maja ; Donati, Giulio ; Volarević, Siniša
Activation of the tumor suppressor p53 upon impairment of ribosome biogenesis
Biochimica et biophysica acta-molecular basis of disease 1842 817-830 - 2013.
Preuzeto sa: https://bib.irb.hr/prikazi-rad?&rad=678696

WOS

8. Velimezi, Georgia; Liontos, Michalis; Vougas, Konstantinos; Roumeliotis, Theodoros; Bartkova, Jirina; Sideridou, Maria; Dereli-Oz, Ayguel; Kocylowski, Maciej; Pateras, Ioannis S; Evangelou, Kostas;
Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer
Nature cell biology 15 967-977 - 2013.

9. Bursać, Slađana ; Cokarić Brdovčak, Maja ; Pfannkuchen, Martin ; Oršolić, Ines ; Golomb, Lior ; Zhu, Yan ; Katz, Chen ; Daftuar, Lylin ; Grabušić, Kristina ; Vukelić, Iva ; Filić, Vedrana ; Oren, Moshe ; Prives, Carol ; Volarević, Siniša
Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress
Proceedings of the National Academy of Sciences of the United States of America 109 20467-20472 - 2012.
Preuzeto sa: https://bib.irb.hr/prikazi-rad?&rad=654680

WOS

10. Bursać, Sladana; Brdovčak, Maja Cokarić; Pfannkuchen, Martin; Orsolić, Ines; Golomb, Lior; Zhu, Yan; Katz, Chen; Daftuar, Lilyn; Grabušić, Kristina; Vukelić, Iva;
Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress
Proceedings of the National Academy of Sciences 109 20467-20472 - 2012.

11. Barkić, Martina ; Crnomarković, Slađana ; Grabušić, Kristina ; Bogetić, Ivana ; Panić, Linda ; Tamarut, Sanda ; Cokarić, Maja ; Jerić, Ines ; Vidak, Sandra ; Volarević, Siniša
The p53 tumor suppressor causes congenital malformations in Rpl24-deficient mice and promotes their survival
Molecular and cellular biology 29 2489-2504 - 2009.
Preuzeto sa: https://bib.irb.hr/prikazi-rad?&rad=352233

WOS

12. Barkić, Martina; Crnomarković, Slađana; Grabušić, Kristina; Bogetić, Ivana; Panić, Linda; Tamarut, Sanda; Cokarić, Maja; Jerić, Ines; Vidak, Sandra; Volarević, Siniša;
The p53 tumor suppressor causes congenital malformations in Rpl24-deficient mice and promotes their survival
Molecular and cellular biology 29 2489-2504 - 2009.

13. Velimezi G, Liontos M, Vougas K, Roumeliotis T, Bartkova J, Sideridou M, Dereli-Oz A, Kocylowski M, Pateras IS, Evangelou K, Kotsinas A, Orsolic I, Bursac S, Cokaric-Brdovcak M, Zoumpourlis V, Kletsas D, Papafotiou G, Klinakis A, Volarevic S, Gu W, Bartek J, Halazonetis TD, Gorgoulis VG.
Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer.
Nature cell biology (1465-7392) 15 (2013); 967-977

14. (Bursać, Slađana; Cokarić Brdovčak, Maja; Phannkuchen, Martin; Oršolić, Ines; Golomb, Lior; Zhu, Yan; Katz, Chen; Daftuar, Lylin; Grabušić, Kristina; Vukelić, Iva; Filić, Vedrana; Oren, Moshe; Prives, Carol; Volarević, Siniša)
Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress
Proceeding of the National Academy of Sciences of the United States of America (0273-1134) 109 (2012), 50; 20467-20472

15. Barkić, Martina; Crnomarković, Slađana; Grabušić, Kristina; Bogetić, Ivana; Panić, Linda; Tamarut, Sanda; Cokarić, Maja; Jerić, Ines; Vidak, Sandra; Volarević, Siniša
The p53 tumor suppressor causes congenital malformations in Rpl24-deficient mice and promotes their survival
Molecular and cellular biology (0270-7306) 29 (2009), 10; 2489-2504

16. Sladana Bursac, Maja Cokaric Brdovcak, Giulio Donati, Sinisa Volarevic,
Activation of the tumor suppressor p53 upon impairment of ribosome biogenesis
Biochimica et biophysica acta-molecular basis of disease (0925-4439) (2013)

17. Kanellis, Dimitris C; Bursac, Sladana; Tsichlis, Philip N; Volarevic, Sinisa; Eliopoulos, Aristides G;
Physical and functional interaction of the TPL2 kinase with Nucleophosmin.
Oncogene (0950-9232) (2014)

Kongresna priopćenja

1.
Cokarić, Brdovčak, Maja ; Bursać, Slađana ; Oršolić, Ines ; Jurada, Deana ; Volarević, Siniša
Ribosomal protein L5 and L11 play a major role in p53 activation upon ribosomal and genotoxic stresses Poster VI. HRVATSKI KONGRES HUMANE GENETIKE Split, Hrvatska - 7.11.2015.
Preuzeto sa: https://bib.irb.hr/prikazi-rad?&rad=812286
2.
Grabušić, Kristina ; Mihovilić, Renata ; Bursać, Slađana ; Volarević, Siniša
RIBOSOMAL PROTEINS L5 AND L11 PARTICIPATE IN ACTIVATION OF THE P53 TUMOR SUPPRESSOR IN RESPONSE TO MANY DIFFERENT STRESSES Predavanje 10th CONGRESS OF THE CROATIAN SOCIETY OF BIOCHEMISTRY AND MOLECULAR BIOLOGY with international participation Opatija, Hrvatska - 18.9.2010.
Preuzeto sa: https://bib.irb.hr/prikazi-rad?&rad=553073
3.
Barkić, Martina ; Crnomarković, Slađana ; Volarević, Siniša
The p53 tumor suppressor permits survival of ribosomal protein L24-deficient mice at the expense of malformations Pozvano EMBO Practical Course: Anatomy and Embryology of the Mouse Zagreb, Hrvatska - 14.9.2008.
Preuzeto sa: https://bib.irb.hr/prikazi-rad?&rad=374302
4.
Barkić M, Crnomarković S, Panić L, Grabušić K, Cokarić M, Tamarut S, Bogetić I, Volarević S.
The p53 tumor suppressor causes congenital malformations in RPL24-deficient mice and promotes their survival. poster prezentacija HDBMB 2008 Congress of the Croatian Society of Biochemistry and Molecular Biology (with international participation) Osijek, Croatia - 1.1.2008.
5.
Cokarić, Brdovčak; Bursać, Slađana; Oršolić, Ines; Jurada, Deana; Volarević, Siniša;
Ribosomal protein L5 and L11 play a major role in p53 activation upon ribosomal and genotoxic stresses
6.
Oršolić, Ines; Bursać, Slađana; Volarević, Siniša;
The Role of Ribosomal Proteins L5 and L11 in Tumor Suppression
7.
Bursać, Slađana;
The role of ribosomal proteins in activation of tumor suppressor p53
8.
Grabušić, Kristina; Mihovilić, Renata; Bursać, Slađana; Volarević, Siniša;
RIBOSOMAL PROTEINS L5 AND L11 PARTICIPATE IN ACTIVATION OF THE P53 TUMOR SUPPRESSOR IN RESPONSE TO MANY DIFFERENT STRESSES
9.
Grabušić, Kristina; Mihovilić, Renata; Bursać, Slađana; Volarević, Siniša
RIBOSOMAL PROTEINS L5 AND L11 PARTICIPATE IN ACTIVATION OF THE P53 TUMOR SUPPRESSOR IN RESPONSE TO MANY DIFFERENT STRESSES
10.
Barkić, Martina; Crnomarković, Slađana; Volarević, Siniša
The p53 tumor suppressor permits survival of ribosomal protein L24-deficient mice at the expense of malformations

Znanstveni projekti

1. 1.12.2012. - 1.12.2015.
Uloga ribosomskih proteina L5 i L11 u aktivaciji tumor supresora p53 i patogenezi zloćudnih tumora; suradnik na projektu; Hrvatska zaklada za znanost; Ukupna ugovorena vrijednost: 1.350.000,00 kn;
2. 1.7.2010. - 30.6.2013.
TransMedRi - Upgrading the capacities for research in translational medicine at the Faculty of Medicine University of Rijeka; suradnik na projektu; REGPOT FP7, European Community ; Ukupna ugovorena vrijednost za WP2: 517.920,00 EUR;
3. 1.2.2009. - 1.2.2011.
Regulacija tumor supresora p53 ribosomalnim proteinima u fiziološkim i patološkim uvjetima; suradnik na projektu; Unity Through Knowledge Fund, MZOŠ; Ukupna ugovorena vrijednost: 1.430.210,80 kn;
4. 1.1.2009. - 30.6.2013.
Razumijevanje nastajanja tumora povezanih s upalom s ciljem racionalnog stvaranja novih terapeutskih strategija protiv zloćudnih tumora; suradnik na projektu; FP7, SP1- Cooperation, Collaborative project, Large-scale integrating project, European Community; Ukupna vrijednost: 641.618,91;
5. 1.1.2007. - 31.12.2013.
Odgovor stanica sisavaca na pogrešku u sintezi ribosoma in vivo; suradnik na projektu; Znanstveni projekt, MZOŠ; Ukupna vrijednost: 1.159.998,43 kn;
6. 28.6.2006. - 28.6.2009.
Proizvodnja monoklonskih protutijela protiv ribosomalnih proteina miša i čovjeka; suradnik na projektu; Tehnologijski projekt, MZOŠ; Ukupna ugovorena vrijednost:1.754.000,00 kn;

Znanstveni skupovi

1. 1.5.2023. -
Live Cell Imaging Microscopy Faculty of Medicine, University of Rijeka, Croatia sudionik
2. 1.9.2013. -
Cell Proliferation in Cancer Faculty of Medicine, University of Rijeka, Croatia sudionik
3. 1.11.2010. - 1.11.2011.
Translational Cancer Research Faculty of Medicine, University of Rijeka, Croatia sudionik
4. - 27.9.2012.
2nd Inflammation, Cancer and Novel Therapeutics Conference and Summer School Malia, Heraklion, Crete, Greece polaznik
5. - 24.9.2012.
4th INFLA-CARE Annual Meeting Malia, Crete, Greece sudionik
6. - 30.9.2010.
1st Inflammation & Cancer Summer School Crete, Greece polaznik
7. - 28.9.2010.
INFLA CARE Annual meeting Crete, Greece sudionik

Javno djelovanje

Novinski članci

1. 20.3.2013. - Detalji
Super Mila
Zagreb
2. 1.3.2013. - Detalji
Cosmopolitan
Zagreb
3. 1.3.2013. - Detalji
Elle
Zagreb
4. 21.2.2013. - Detalji
Gloria
Zagreb
5. 8.2.2013. - Detalji
Novi list
Rijeka

Medijski nastupi

1. 22.4.2013. - Detalji
Dnevnik Nove TV
Rijeka
2. 17.2.2013. - Detalji
Kanal RI
Rijeka
3. 9.2.2013. - Detalji
HTV1
Zagreb
4. 6.2.2013. - Detalji
Dnevnik Nove TV
Zagreb