Petra Grbčić mag. pharm. inv.

Odjel za biotehnologiju Centar za visokopropusne tehnologije

e-pošta : petra.grbcic@biotech.uniri.hr

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Obrazovanje

1.9.2015. - Doktorski studij: Medicinska kemija Odjel za biotehnologiju, Sveučilište u Rijeci
1.9.2013. - 27.7.2015. magistra istraživanja i razvoja lijekova Diplomski sveučilišni studij: Istraživanje i razvoj lijekova Odjel za biotehnologiju, Sveučilište u Rijeci
1.9.2010. - 20.7.2013. prvostupnica biotehnologije i istraživanja lijekova Prediplomski sveučilišni studij: Biotehnologija i istraživanje lijekova Odjel za biotehnologiju, Sveučilište u Rijeci

Radno iskustvo

1.6.2018. - Suradnik i asistent Suradnik i asistent iz interdisciplinarnog znanstvenog područja, znanstvenog polja: Biotehnologija u biomedicini, za rad na projektu „Bioprospecting Jadranskog mora“, KK.01.1.1.01.0002. Sveučilište u Rijeci, Odjel za biotehnologiju, Centar za visokopropusne tehnologije
10.6.2013. - 21.6.2013. Studentska praksa Odjel za istraživanje i razvoj Jadran galenski laboratorij (JGL d.d.)

Nastavna djelatnost

Kolegiji

- IRL105 Toksikologija lijekova
Diplomski sveučilišni studij "Istraživanje i razvoj lijekova"
Odjel za biotehnologiju
Održavanje praktičnih vježbi
Norma sati:
- IRL103 Metode istraživanja proteina
Diplomski sveučilišni studij
Odjel za biotehnologiju
Održavanje praktičnih vježbi
Norma sati:
- Toksikologija lijekova
Poslijediplomski specijalistički studij: Klinička farmakologija: ispitivanje i primjena lijekova
Medicinski fakultet Sveučilišta u Rijeci
Održavanje praktičnih vježbi
Norma sati:

Znanstvena i umjetnička djelatnost

Znanstveni radovi

1. Sedić, Mirela; Grbčić, Petra; Kraljević Pavelić, Sandra
Bioactive Sphingolipids as Biomarkers Predictive of Disease Severity and Treatment Response in Cancer: Current Status and Translational Challenges
Review paper 39 41-56 - 2019. http://ar.iiarjournals.org/content/39/1/41.abstract

Q1

2. Bistrović, Andrea; Grbčić, Petra; Harej, Anja; Sedić, Mirela; Kraljević Pavelić, Sandra; Koštrun, Sanja; Plavec, Janez; Makuc, Damjan; Raić-Malić, Silvana
Small molecule purine and pseudopurine derivatives: synthesis, cytostatic evaluations and investigation of growth inhibitory effect in non- small cell lung cancer A549
Journal of enzyme inhibition and medicinal chemistry 33 271-285 - 2018. https://www.ncbi.nlm.nih.gov/pubmed/29271659

Q1

3. Racané, Livio; Ptiček, Lucija; Sedić, Mirela; Grbčić, Petra; Kraljević Pavelić, Sandra; Bertoša, Branimir; Sović, Irena; Karminski-Zamola, Grace
Eco-friendly synthesis, in vitro anti- proliferative evaluation and 3D-QSAR analysis of a novel series of monocationic 2- aryl/heteroaryl-substituted 6-(2- imidazolinyl)benzothiazole mesylates
Biochemistry & Biophysics, Springer International Publishing - 2018. https://www.ncbi.nlm.nih.gov/pubmed/29667008

Q1

4. Jelovica, Mateo; Grbčić, Petra; Mušković, Martina; Sedić, Mirela; Kraljević Pavelić, Sandra ; Lončarić, Martin; Malatesti, Nela
In Vitro Photodynamic Activity of N-Methylated and N-Oxidised Tripyridyl Porphyrins with Long Alkyl Chains and Their Inhibitory Activity in Sphingolipid Metabolism
ChemMedChem 13 360-372 - 2018. https://www.ncbi.nlm.nih.gov/pubmed/29381258

Q1

5. Klobučar, Marko; Grbčić, Petra; Pavelić, Sandra Kraljević; Jonjić, Nives; Visentin, Sarah; Sedić, Mirela;
Acid ceramidase inhibition sensitizes human colon cancer cells to oxaliplatin through downregulation of transglutaminase 2 and ß1 integrin/FAK- mediated signalling
Biochemical and Biophysical Research Communications - 2018.

6. Andrea Bistrović, Luka Krstulović, Anja Harej, Petra Grbčić, Mirela Sedić, Sanja Koštrun, Sandra Kraljević Pavelić, Miroslav Bajić, Silvana Raić-Malić
Design, synthesis and biological evaluation of novel benzimidazole amidines as potent multi-target inhibitors for the treatment of non-small cell lung cancer
European journal of medicinal chemistry 143 1616-1634 - 2017. https://www.ncbi.nlm.nih.gov/pubmed/29133046

Q1

7. Andrea Bistrović, Anja Harej, Petra Grbčić, Mirela Sedić, Sandra Kraljević Pavelić, Mario Cetina,Silvana Raić-Malić
Synthesis and Anti-Proliferative Effects of Mono- and Bis-Purinomimetics Targeting Kinases
International journal of molecular sciences 18 2292-2312 - 2017. https://www.ncbi.nlm.nih.gov/pubmed/29104242

Q1

8. Grbčić, Petra; Tomljanović, Ivana; Klobučar, Marko; Pavelić, Sandra Kraljević; Lučin, Ksenija; Sedić, Mirela;
Dual sphingosine kinase inhibitor SKI-II enhances sensitivity to 5-fluorouracil in hepatocellular carcinoma cells via suppression of osteopontin and FAK/IGF-1R signalling
Biochemical and Biophysical Research Communications 487 782-788 - 2017.

9. Gregorić, Tomislav; Sedić, Mirela; Grbčić, Petra; Tomljenović Paravić, Andrea; Kraljević Pavelić, Sandra; Cetina, Mario; Vianello, Robert; Raić-Malić, Silvana
Novel pyrimidine-2, 4-dione-1, 2, 3-triazole and furo[2, 3-d]pyrimidine-2-one-1, 2, 3-triazole hybrids as potential anti-cancer agents: Synthesis, computational and X-ray analysis and biological evaluation
European journal of medicinal chemistry 125 1247-1267 - 2016. https://www.ncbi.nlm.nih.gov/pubmed/27875779

Q1

Kongresna priopćenja

1.
Klobučar M., Grbčić P., Visentin S., Kraljević Pavelić S., Jonjić N. and Sedić M.
Acid ceramidase activity regulates the sensitivity of human colon cancer cells to oxaliplatin Poster i usmena prezentacija na engleskom jeziku 13th Central European Oncology Congress Opatija, Hrvatska - 21.6.2017. http://web.penta-pco.com/ceoc2017
2.
Grbcic P., Tomljanovic I., Klobucar M., Kraljevic Pavelic S. and Sedic M.
Dual inhibition of sphingosine kinase 1/2 enhances antitumor activity of 5-fluorouracil in human hepatocellular carcinoma cells in vitro Postersko priopćenje Gordon Research Conference Glycolipid and Sphingolipid Homeostasis and Function in Health and Disease Renaissance Tuscany Il Ciocco, Lucca (Barga), Italija - 6.3.2016. https://www.grc.org/programs.aspx?id=12366
3.
Ilic N., Grbcic P., Tomljanovic I., Kraljevic Pavelic S. and Sedic M.
Sphingosine kinase inhibition sensitizes hepatocellular carcinoma cells to chemotherapy Poster i usmena prezentacija na engleskom jeziku 11th Central European Oncology Congress, Croatian Society of Oncology’s Best of ASCO® Conference Opatija, Hrvatska - 1.6.2015. http://www.penta-pco.com/congress/content.php?id=39&pageID=138&lang=EN
4.
Bistrović, Andrea; Krstulović, Luka; Grbčić, Petra; Harej, Anja; Sedić, Mirela; Pavelić, Sandra Kraljević; Bajić, Miroslav; Raić-Malić, Silvana;
Novel 5-amidino benzimazoles as selective cytostatic agents against lung cancer cells Postersko priopćenje 25th CROATIAN MEETING OF CHEMISTS AND CHEMICAL ENGINEERS
5.
Bistrović, Andrea; Krstulović, Luka; Grbčić, Petra; Harej, Anja; Sedić, Mirela; Pavelić, Sandra Kraljević; Bajić, Miroslav; Raić-Malić, Silvana;
Novel triazole-linked 5-amidino benzimidazoles as potent multi-target inhibitors for the treatment of non-small cell lung cancer Postersko priopćenje VII EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry
6.
Maračić, Silvija; Šimek, Helena; Grbčić, Petra; Sedić, Mirela; Stolić, Ivana; Pavelić, Sandra Kraljević; Raić-Malić, Silvana;
Biological evaluations of amidine and amidoxime substituted heterocycles with 1, 2, 3-triazolyl spacer Postersko priopćenje The 10th Joint Meeting on Medicinal Chemistry
7.
Racané, Livio; Ptiček, Lucija; Sedić, Mirela; Grbčić, Petra; Pavelić, Sandra Kraljević; Sović, Irena; Karminski-Zamola, Grace;
SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL 2-(HETERO) ARYL-6-(2-IMIDAZOLINYL) BENZOTHIAZOLES AS ANTICANCER AGENTS Postersko priopćenje The 10th Joint Meeting on Medicinal Chemistry

Stručna djelatnost