Dr.sc. Karlo Wittine

Odjel za biotehnologiju Zavod za medicinsku kemiju

telefon : +385 51 584587

Obrazovanje

23.7.2014. - Docent Odjel za biotehnologiju, Sveučilište u Rijeci
11.1.2013. - Znanstveni suradnik Fakultet kemijskog inženjerstva i tehnologije, Sveučilište u Zagrebu
8.7.2010. - Doktor znanosti Prirodoslovno-matematički fakultet, Sveučilište u Zagrebu
19.12.2002. - Diplomirani kemijski inžnjer Fakultet kemijskog inženjerstva i tehnologije, Sveučilište u Zagrebu
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Radno iskustvo

- Docent Odjel za biotehnologiju, Sveučilište u Rijeci
- Znanstveni suradnik Fakultet kemijskog inženjerstva i tehnologije
- Asistent Fakultet kemijskog inženjerstva i tehnologije

Nastavna djelatnost

Kolegiji

30.5.2016. - Medicinska kemija protutumorskih lijekova (EBIL 145)
Diplomski sveučilišni studij-Medicinska kemija
Sveučilište u Rijeci, Odjel za biotehnologiju
voditelj
Norma sati: 60
11.1.2016. - Izabrane teme organske sinteze (MK 201)
Diplomski sveučilišni studij-Medicinska kemija
Sveučilište u Rijeci, Odjel za biotehnologiju
voditelj
Norma sati: 53.5
2.11.2015. - Uvod u bioanorgansku kemiju (BIL 106)
Preddiplomski sveučilišni studij-Biotehnologija i istraživanje lijekova
Sveučilište u Rijeci, Odjel za biotehnologiju
voditelj
Norma sati: 125

Osobni razvoj

1.1.2015. - Teaching professionals to teach (TP2T)


Norma sati: 16 sati
1.1.2014. - Nastavničke kompetencije u visokom školstvu: Učenje i poučavanje


Norma sati: 10 ECTS

Izdavaštvo

- Novi lijekovi protiv raka

Financiranje: Školska knjiga
- Strategije razvoja protuvirusnih lijekova

Financiranje: Medicinska naklada

Znanstvena i umjetnička djelatnost

Znanstveni radovi

1. Kereković, I.; Wittine, K.
Properties of gold electrode modified with dimercapto- succinic acid and electrochemical behaviour of copper histidine complex
Journal of analytical chemistry 71 289-295 - 2016. 10.1134/S1061934816030047

Q3

2. Malatesti, Nela; Harej, Anja; Kraljević Pavelić, Sandra; Lončarić, Martin; Zorc, Hrvoje; Wittine, Karlo; Andjelkovic, Uros; Josic, Djuro
Synthesis, characterisation and in vitro investigation of photodynamic activity of 5-(4- octadecanamidophenyl)-10, 15, 20-tris(N- methylpyridinium-3-yl)porphyrin trichloride on HeLa cells using low light fluence rate
Photodiagnosis and Photodynamic Therapy 15 115-126 - 2016. 10.1016/j.pdpdt.2016.07.003

Q2

3. Wittine, Karlo; Ratkaj, Ivana; Benci, Krešimir; Suhina, Tomislav; Mandić, Leo; Ilić, Nataša; Kraljević Pavelić, Sandra; Pavelić, Krešimir; Mintas, Mladen
The novel coumarin[3, 2-c]thiophene and its hydroxamic acid and ureido derivatives : synthesis and cytostatic activity evaluations
Medicinal chemistry research 25 728-737 - 2016. 10.1007/s00044-016-1523-0

Q3

4. Stipković Babić, Maja; Makuc, Damjan; Plavec, Janez; Martinović, Tamara; Kraljević Pavelić, Sandra; Pavelić, Krešimir; Snoeck, Robert; Andrei, Graciela; Schols, Dominique; Wittine, Karlo; Mintas, Mladen
Novel halogenated 3-deazapurine, 7-deazapurine and alkylated 9-deazapurine derivatives of L-ascorbic or imino-L-ascorbic acid: Synthesis, antitumour and antiviral activity evaluations
European journal of medicinal chemistry 102 288-302 - 2015. 10.1016/j.ejmech.2015.08.008

Q1

5. Wittine, Karlo; Poljak, Kristina; Kovač, Matea; Makuc, Damjan; Plavec, Janez; Balzarini, Jan; Martinović, Tamara; Kraljević Pavelić, Sandra; Pavelić, Krešimir; Mintas, Mladen
The Novel [4,5-e][1,3]Diazepine-4,8-dione and Acyclic Carbamoyl Imino-Ureido Derivatives of Imidazole : Synthesis, Anti-Viral and Anti-Tumor Activity Evaluations
Molecules 18 13385-13397 - 2013. 10.3390/molecules181113385

Q2

6. Benci, Krešimir; Mandić, Leo; Suhina, Tomislav; Sedić, Mirela; Klobučar, Marko; Kraljević Pavelić, Sandra; Pavelić, Krešimir; Wittine, Karlo; Mintas, Mladen.
Novel Coumarin Derivatives Containing 1, 2, 4-Triazole, 4, 5-Dicyanoimidazole and Purine Moieties: Synthesis and Evaluation of Their Cytostatic Activity
Molecules 17 11010-11025 - 2012. 10.3390/molecules170911010

Q2

7. Wittine, Karlo; Stipković Babić, Maja; Makuc, Damjan; Plavec, Janez; Kraljević Pavelić, Sandra; Sedić, Mirela; Pavelić, Krešimir; Leyssene, Pieter; Neytse, Johan; Balzarini, Jan; Mintas, Mladen
Novel 1, 2, 4-Triazole and Imidazole Derivatives of L-Ascorbic and Imino-Ascorbic Acid: Synthesis, Anti-HCV and Antitumor Activity Evaluations
Bioorganic & medicinal chemistry 20 3675-3685 - 2012. 10.1016/j.bmc.2012.01.054

Q1

8. Wittine, Karlo; Benci, Krešimir; Kraljević Pavelić, Sandra; Pavelić, Krešimir; Bratulić, Siniša; Hock, Karlo; Balzarini, Jan; Mintas, Mladen
Synthesis, cytostatic and anti-viral activity evaluation of the novel acyclic nucleoside analogues containing a sterically constrained (Z)-4-amino-2-butenyl moiety
Medicinal chemistry research 20 280-287 - 2011. 10.1007/s00044-010-9318-1

Q3

9. Wittine, Karlo; Stipković Babić, Maja; Košutić, Marija; Cetina, Mario; Rissanen, Kari; Kraljević Pavelić, Sandra; Tomljenović Paravić, Andrea; Sedić, Mirela; Pavelić, Krešimir; Mintas, Mladen
The new 5- or 6-azapyrimidine and cyanuric acid derivatives of L-ascorbic acid bearing the free C-5 hydroxy or C-4 amino group at the ethylenic spacer: CD-spectral absolute configuration determination and biological activity evaluations
European journal of medicinal chemistry 46 2770-2785 - 2011. 10.1016/j.ejmech.2011.03.066

Q1

10. Benci, Krešimir; Suhina, Tomislav; Mandić, Leo; Kraljević Pavelić, Sandra; Tomljenović Paravić, Andrea; Pavelić, Krešimir; Balzarini, Jan; Wittine, Karlo; Mintas, Mladen
Novel 1, 2, 4-triazole and purine acyclic cyclopropane nucleoside analogues : synthesis, antiviral and cytostatic activity evaluations
Antiviral Chemistry & Chemotherapy 21 221-230 - 2011. 10.3851/IMP1762

Q2

11. Benci, Krešimir; Wittine, Karlo; Radan, Malajka; Cetina, Mario; Sedić, Mirela; Kraljević Pavelić, Sandra; Pavelić, Krešimir; DeClercq, Erik; Mintas, Mladen
The unsaturated acyclic nucleoside analogues bearing a sterically constrained (Z)-4'-benzamido-2'-butenyl moiety : Synthesis, X-ray crystal structure study, cytostatic and antiviral activity evaluations
Bioorganic & medicinal chemistry 18 6249-6257 - 2010. 10.1016/j.bmc.2010.07.035

Q2

12. Wittine, Karlo; Benci, Krešimir; Rajić, Zrinka; Zorc, Branka; Kralj, Marijeta; Marjanović, Marko; Pavelić, Krešimir; De Clercq, Eric; Andrei, Graciela; Snoeck, Robert; Balzarini, Jan; Mintas, Mladen
The novel phosphoramidate derivatives of NSAID 3-hydroxypropylamides: synthesis, cytostatic and antiviral activity evaluations
European journal of medicinal chemistry 44 143-151 - 2009. 10.1016/j.ejmech.2008.03.037

Q1

13. Gazivoda, Tatjana; Wittine, Karlo; Lovrić, Iva; Makuc, Damjan; Plavec, Janez; Cetina, Mario; Mrvoš-Sermek, Draginja; Šuman, Lidija; Kralj, Marijeta; Pavelić, Krešimir; Mintas, Mladen; Raić-Malić, Silvana
Synthesis, Structural Studies and Cytostatic Evaluation of 5, 6-di-O-Modified L-Ascorbic Acid Derivatives
Carbohydrate research 341 433-442 - 2006. 10.1016/j.carres.2005.12.010

Q2

14. Wittine, Karlo; Gazivoda, Tatjana; Markuš, Marko; Mrvoš-Sermek, Draginja; Hergold-Brundić, Antonija; Cetina, Mario; Žiher, Dinko; Gabelica, Vesna; Mintas, Mladen; Raić-Malić, Silvana
Crystal Structures, Circular Dichroism Spectra and Absolute Configurations of Some L-Ascorbic Acid Derivatives
Journal of Molecular Structure 687 101-106 - 2004. 10.1016/j.molstruc.2003.09.019

Q3

15. Cetina, Mario; Benci, Krešimir; Wittine, Karlo; Mladen, Mintas
Weak C-H•••? and C-H•••F interactions form higher-order supramolecular structures in cytosine and uracil (Z)-4’-benzamido-2’-butenyl derivative
Crystal growth & design 12 5262-5270 http://pubs.acs.org/doi/abs/10.1021/cg300774d?prevSearch=%255BTitle%253A%2Binteractions%2Bform%2Bhigher-order%2Bsupramolecular%2Bstructures%2Bin%2Bcytosine%255D&searchHistoryKey=

Kongresna priopćenja

1.
Wittine, Karlo ; Rajić, Zrinka ; Zorc, Branka ; Kralj, Marijeta ; Pavelić, Krešimir ; De Clercq, Erik ; Balzarini, Jan ; Raić-Malić, Silvana ; Mintas, Mladen
The novel 3-hydroxypropylamide derivatives of nonsteroidal antiinflammatory drugs and their phosphoroamidate prodrugs: synthesis, cytostatic and antiviral activity evaluations Poster The 15th European Symposium on Organic Chemistry Dublin, Irska
2.
Wittine, Karlo ; Benci, Krešimir ; Kraljević-Pavelić, Sandra ; Pavelić, Krešimir ; Balzarini, Jan ; Mintas, Mladen
Synthesis, cytostatic and nativiral activity evaluations of the novel unsaturated acyclic nucleoside analogues Poster XXth International Symposium on Medicinal Chemistry Beč, Austrija
3.
Benci, Krešimir; Suhina, Tomislav; Mandić, Leo; Kraljević Pavelić, Sandra; Tomljenović Paravić, Andrea; Pavelić, Krešimir; Balzarini, Jan; Wittine, Karlo; Mintas, Mladen.
Novel 1,2,4-triazole and purine acyclic cyclopropane nucleoside analogues: synthesis, antiviral and cytostatic activity evaluations Poster International Symposium on Advances in Synthetic and Medicinal Chemistry St. Petersburg, Rusija
4.
Wittine, Karlo; Stipković Babić, Maja; Košutić, Marija; Cetina, Mario; Rissanen, Kari; Kraljević Pavelić, Sandra; Tomljenović Paravić, Andrea; Sedić, Mirela; Pavelić, Krešimir; Mintas, Mladen.
The new 5- or 6-azapyrimidine and cyanuric acid derivatives of L-ascorbic acid bearing the free C-5 hydroxy or C-4 amino group at the ethylenic spacer: CD-spectral absolute configuration determination and biological activity evaluations Poster International Symposium on Advances in Synthetic and Medicinal Chemistry St. Petersburg, Rusija
5.
Wittine, Karlo ; Benci, Krešimir ; Kraljević Pavelić, Sandra ; Pavelić, Krešimir ; Bratulić, Siniša ; Hock, Karlo ; Balzarini, Jan ; Mintas, Mladen
The Novel Acyclic Nucleoside Analogues Containing a Sterically Constrained (Z)-4-amino-2-butenyl Moiety: Synthesis, Cytostatic and Antiviral Activity Evaluation Poster XXI. Hrvatski skup kemičara i kemijskih inženjera Trogir, Hrvatska
6.
Cetina, Mario ; Benci, Krešimir ; Wittine, Karlo ; Mintas, Mladen
Weak intermolecular interactions form higher-order supramolecular structures in cytosine (Z)-4’-benzamido-2’-butenyl derivatives Predavanje Twenty-first Slovenian-Croatian Crystallographic Meeting Ljubljana, Slovenija
7.
Wittine, Karlo; Stipković-Babić, Maja; Košutić, Marija; Mintas, Mladen.
Sinteza novih pirimidinskih derivata L-askorbinske kiseline radi ispitivanja citostatskih djelovanja Poster XXII. Hrvatski skup kemičara i kemijskih inženjera Zagreb, Hrvatska
8.
Wittine, Karlo ; Benci, Krešimir ; Kraljević Pavelić, Sandra ; Pavelić, Krešimir ; Balzarini, Jan ; Mintas, Mladen
The novel unsaturated acyclic nucleoside analogues: cytostatic and antiviral activity evaluations Poster Symposium of the 18th Internationa Roundtable on Nucleosides, Nucleotides and Nucleic Acids and the 35th International Sumposium on Nucleic Acids Chemistry Kyoto, Japan
9.
Wittine, Karlo ; Benci, Krešimir ; Mintas, Mladen
Synthesis of the novel unsaturated acyclic nucleoside analogues Poster XIV Symposium on chemistry of nucleic acid components Češki Krumlov, Češka Republika
10.
Wittine, Karlo; Stipković Babić, Maja; Kraljević Pavelić Sandra; Pavelić Krešimir; Mintas Mladen
Synthesis and cytostatic activity evaluation of pyrimidine ad purine derivatives of L-ascorbic acid Poster EFMC-ISMC 2010 XXIst International symposium on medicinal chemistry Bruxelles, Belgija
11.
Benci, Krešimir; Mandić, Leo; Suhina, Tomislav; Sedić, Mirela; Klobučar, Marko; Kraljević Pavelić, Sandra; Pavelić, Krešimir; Wittine, Karlo; Mintas, Mladen.
Novel Coumarin Derivatives Containing 1,2,4-Triazole, 4 5-Dicyanoimidazole and Purine Moiety: Synthesis and Evaluation of Cytostatic Activity Poster ISMC 2012, XXIInd International Symposium on Medicinal Chemistry Berlin, Njemačka
12.
Benci, Krešimir; Mandić, Leo; Suhina, Tomislav; Wittine, Karlo; Mintas, Mladen.
Synthesis of Novel Ureido and Hydroxamic Derivatives of Coumarin[4,3-c]thiophene Poster ISMC 2012, XXIInd International Symposium on Medicinal Chemistry Berlin, Njemačka
13.

Znanstveni projekti

1. 1.1.2009. - 1.1.2011.
Razvoj novih kemoterapeutika; Član tima; IRCRO; ;
2. 1.1.2007. - 1.1.2014.
Razvoj novih prolijekova i lijekova protiv virusa i raka ; Znanstveni novak/suradnik, sinteza spojeva; MZOŠ; ;
3. 1.1.2004. - 1.1.2005.
Sinteza, strukturna i biološka istraživanja modificiranih nukleozida i ; Znanstveni novak, sinteza spojeva; MZOŠ; ;
4. 1.1.2002. - 1.1.2005.
Razvoj novih terapijskih i dijagnostičkih supstancija za gensku terapiju raka; Volonter i znanstveni novak, sinteza novih klasa spojeva; MZOŠ; ;
5. -
BioProCro - Centar izvrsnosti za bioprospecting Jadranskog mora; Član; Europski fond za regionalni razvoj; ;
6. -
; ; ; ;

Stručna djelatnost


Administrativna djelatnost

Povjerenstva na sveučilištu

1. - - Član
Odjel za biotehnologiju / Povjerenstvo za poslijediplomske studije
2. - - Zamjenik predsjednika
Odjel za biotehnologiju / Etičko povjerenstvo
3. - - Član
Odjel za biotehnologiju / Povjerenstvo za izdavačku djelatnost