Dr.sc. Karlo Wittine

Odjel za biotehnologiju Zavod za medicinsku kemiju

telefon : +385 51 584587

Obrazovanje

1.1.2014. - Docent Odjel za biotehnologiju, Sveučilište u Rijeci
1.1.2013. - Znanstveni suradnik Fakultet kemijskog inženjerstva i tehnologije, Sveučilište u Zagrebu
1.1.2010. - Doktor znanosti Prirodoslovno-matematički fakultet, Sveučilište u Zagrebu
1.1.2002. - Diplomirani kemijski inženjer Fakultet kemijskog inženjerstva i tehnologije, Sveučilište Zagrebu

Radno iskustvo

1.1.2013. - Znanstveni novak Odjel za biotehnologiju, Sveučilište u Rijeci
1.1.2004. - 1.1.2013. Znanstveni novak Fakultet kemijskog inženjerstva i tehnologije

Nastavna djelatnost

Kolegiji

1.1.2015. - Izabrane teme organske sinteze (MK 201)
Diplomski sveučilišni studij-Medicinska kemija
Sveučilište u Rijeci, Odjel za biotehnologiju
voditelj
Norma sati: 47
1.1.2015. - Medicinska kemija protutumorskih lijekova (EBIL 145)
Diplomski sveučilišni studij-Medicinska kemija
Sveučilište u Rijeci, Odjel za biotehnologiju
voditelj
Norma sati: 60
1.1.2014. - Uvod u bioanorgansku kemiju (BIL 106)
Preddiplomski sveučilišni studij-Biotehnologija i istraživanje lijekova
Sveučilište u Rijeci, Odjel za biotehnologiju
voditelj
Norma sati: 170

Osobni razvoj

1.1.2015. - Teaching professionals to teach (TP2T)


Norma sati: 16 sati
1.1.2014. - Nastavničke kompetencije u visokom školstvu: Učenje i poučavanje


Norma sati: 10 ECTS

Znanstvena i umjetnička djelatnost

Znanstveni radovi

1. Kereković, I.; Wittine, K.
Properties of gold electrode modified with dimercapto- succinic acid and electrochemical behaviour of copper histidine complex
Journal of analytical chemistry 71 289-295 - 2016. 10.1134/S1061934816030047

Q3

2. Malatesti, Nela; Harej, Anja; Kraljević Pavelić, Sandra; Lončarić, Martin; Zorc, Hrvoje; Wittine, Karlo; Andjelkovic, Uros; Josic, Djuro
Synthesis, characterisation and in vitro investigation of photodynamic activity of 5-(4- octadecanamidophenyl)-10, 15, 20-tris(N- methylpyridinium-3-yl)porphyrin trichloride on HeLa cells using low light fluence rate
Photodiagnosis and Photodynamic Therapy 15 115-126 - 2016. 10.1016/j.pdpdt.2016.07.003

Q2

3. Wittine, Karlo; Ratkaj, Ivana; Benci, Krešimir; Suhina, Tomislav; Mandić, Leo; Ilić, Nataša; Kraljević Pavelić, Sandra; Pavelić, Krešimir; Mintas, Mladen
The novel coumarin[3, 2-c]thiophene and its hydroxamic acid and ureido derivatives : synthesis and cytostatic activity evaluations
Medicinal chemistry research 25 728-737 - 2016. 10.1007/s00044-016-1523-0

Q3

4. Stipković Babić, Maja; Makuc, Damjan; Plavec, Janez; Martinović, Tamara; Kraljević Pavelić, Sandra; Pavelić, Krešimir; Snoeck, Robert; Andrei, Graciela; Schols, Dominique; Wittine, Karlo; Mintas, Mladen
Novel halogenated 3-deazapurine, 7-deazapurine and alkylated 9-deazapurine derivatives of L-ascorbic or imino-L-ascorbic acid: Synthesis, antitumour and antiviral activity evaluations
European journal of medicinal chemistry 102 288-302 - 2015. 10.1016/j.ejmech.2015.08.008

Q1

5. Wittine, Karlo; Poljak, Kristina; Kovač, Matea; Makuc, Damjan; Plavec, Janez; Balzarini, Jan; Martinović, Tamara; Kraljević Pavelić, Sandra; Pavelić, Krešimir; Mintas, Mladen
The Novel [4,5-e][1,3]Diazepine-4,8-dione and Acyclic Carbamoyl Imino-Ureido Derivatives of Imidazole : Synthesis, Anti-Viral and Anti-Tumor Activity Evaluations
Molecules 18 13385-13397 - 2013. 10.3390/molecules181113385

Q2

6. Benci, Krešimir; Mandić, Leo; Suhina, Tomislav; Sedić, Mirela; Klobučar, Marko; Kraljević Pavelić, Sandra; Pavelić, Krešimir; Wittine, Karlo; Mintas, Mladen.
Novel Coumarin Derivatives Containing 1, 2, 4-Triazole, 4, 5-Dicyanoimidazole and Purine Moieties: Synthesis and Evaluation of Their Cytostatic Activity
Molecules 17 11010-11025 - 2012. 10.3390/molecules170911010

Q2

7. Wittine, Karlo; Stipković Babić, Maja; Makuc, Damjan; Plavec, Janez; Kraljević Pavelić, Sandra; Sedić, Mirela; Pavelić, Krešimir; Leyssene, Pieter; Neytse, Johan; Balzarini, Jan; Mintas, Mladen
Novel 1, 2, 4-Triazole and Imidazole Derivatives of L-Ascorbic and Imino-Ascorbic Acid: Synthesis, Anti-HCV and Antitumor Activity Evaluations
Bioorganic & medicinal chemistry 20 3675-3685 - 2012. 10.1016/j.bmc.2012.01.054

Q1

8. Wittine, Karlo; Benci, Krešimir; Kraljević Pavelić, Sandra; Pavelić, Krešimir; Bratulić, Siniša; Hock, Karlo; Balzarini, Jan; Mintas, Mladen
Synthesis, cytostatic and anti-viral activity evaluation of the novel acyclic nucleoside analogues containing a sterically constrained (Z)-4-amino-2-butenyl moiety
Medicinal chemistry research 20 280-287 - 2011. 10.1007/s00044-010-9318-1

Q3

9. Wittine, Karlo; Stipković Babić, Maja; Košutić, Marija; Cetina, Mario; Rissanen, Kari; Kraljević Pavelić, Sandra; Tomljenović Paravić, Andrea; Sedić, Mirela; Pavelić, Krešimir; Mintas, Mladen
The new 5- or 6-azapyrimidine and cyanuric acid derivatives of L-ascorbic acid bearing the free C-5 hydroxy or C-4 amino group at the ethylenic spacer: CD-spectral absolute configuration determination and biological activity evaluations
European journal of medicinal chemistry 46 2770-2785 - 2011. 10.1016/j.ejmech.2011.03.066

Q1

10. Benci, Krešimir; Suhina, Tomislav; Mandić, Leo; Kraljević Pavelić, Sandra; Tomljenović Paravić, Andrea; Pavelić, Krešimir; Balzarini, Jan; Wittine, Karlo; Mintas, Mladen
Novel 1, 2, 4-triazole and purine acyclic cyclopropane nucleoside analogues : synthesis, antiviral and cytostatic activity evaluations
Antiviral Chemistry & Chemotherapy 21 221-230 - 2011. 10.3851/IMP1762

Q2

11. Benci, Krešimir; Wittine, Karlo; Radan, Malajka; Cetina, Mario; Sedić, Mirela; Kraljević Pavelić, Sandra; Pavelić, Krešimir; DeClercq, Erik; Mintas, Mladen
The unsaturated acyclic nucleoside analogues bearing a sterically constrained (Z)-4'-benzamido-2'-butenyl moiety : Synthesis, X-ray crystal structure study, cytostatic and antiviral activity evaluations
Bioorganic & medicinal chemistry 18 6249-6257 - 2010. 10.1016/j.bmc.2010.07.035

Q2

12. Wittine, Karlo; Benci, Krešimir; Rajić, Zrinka; Zorc, Branka; Kralj, Marijeta; Marjanović, Marko; Pavelić, Krešimir; De Clercq, Eric; Andrei, Graciela; Snoeck, Robert; Balzarini, Jan; Mintas, Mladen
The novel phosphoramidate derivatives of NSAID 3-hydroxypropylamides: synthesis, cytostatic and antiviral activity evaluations
European journal of medicinal chemistry 44 143-151 - 2009. 10.1016/j.ejmech.2008.03.037

Q1

13. Gazivoda, Tatjana; Wittine, Karlo; Lovrić, Iva; Makuc, Damjan; Plavec, Janez; Cetina, Mario; Mrvoš-Sermek, Draginja; Šuman, Lidija; Kralj, Marijeta; Pavelić, Krešimir; Mintas, Mladen; Raić-Malić, Silvana
Synthesis, Structural Studies and Cytostatic Evaluation of 5, 6-di-O-Modified L-Ascorbic Acid Derivatives
Carbohydrate research 341 433-442 - 2006. 10.1016/j.carres.2005.12.010

Q2

14. Wittine, Karlo; Gazivoda, Tatjana; Markuš, Marko; Mrvoš-Sermek, Draginja; Hergold-Brundić, Antonija; Cetina, Mario; Žiher, Dinko; Gabelica, Vesna; Mintas, Mladen; Raić-Malić, Silvana
Crystal Structures, Circular Dichroism Spectra and Absolute Configurations of Some L-Ascorbic Acid Derivatives
Journal of Molecular Structure 687 101-106 - 2004. 10.1016/j.molstruc.2003.09.019

Q3

15. Cetina, Mario; Benci, Krešimir; Wittine, Karlo; Mladen, Mintas
Weak C-H•••? and C-H•••F interactions form higher-order supramolecular structures in cytosine and uracil (Z)-4’-benzamido-2’-butenyl derivative
Crystal growth & design 12 5262-5270 http://pubs.acs.org/doi/abs/10.1021/cg300774d?prevSearch=%255BTitle%253A%2Binteractions%2Bform%2Bhigher-order%2Bsupramolecular%2Bstructures%2Bin%2Bcytosine%255D&searchHistoryKey=

Kongresna priopćenja

1.
Benci, Krešimir; Mandić, Leo; Suhina, Tomislav; Sedić, Mirela; Klobučar, Marko; Kraljević Pavelić, Sandra; Pavelić, Krešimir; Wittine, Karlo; Mintas, Mladen.
Novel Coumarin Derivatives Containing 1,2,4-Triazole, 4 5-Dicyanoimidazole and Purine Moiety: Synthesis and Evaluation of Cytostatic Activity Poster ISMC 2012, XXIInd International Symposium on Medicinal Chemistry Berlin - 1.1.2012.
2.
Benci, Krešimir; Mandić, Leo; Suhina, Tomislav; Wittine, Karlo; Mintas, Mladen.
Synthesis of Novel Ureido and Hydroxamic Derivatives of Coumarin[4,3-c]thiophene Poster ISMC 2012, XXIInd International Symposium on Medicinal Chemistry Berlin - 1.1.2012.
3.
Benci, Krešimir; Suhina, Tomislav; Mandić, Leo; Kraljević Pavelić, Sandra; Tomljenović Paravić, Andrea; Pavelić, Krešimir; Balzarini, Jan; Wittine, Karlo; Mintas, Mladen.
Novel 1,2,4-triazole and purine acyclic cyclopropane nucleoside analogues: synthesis, antiviral and cytostatic activity evaluations Poster International Symposium on Advances in Synthetic and Medicinal Chemistry St. Petersburg - 1.1.2011.
4.
Wittine, Karlo; Stipković Babić, Maja; Košutić, Marija; Cetina, Mario; Rissanen, Kari; Kraljević Pavelić, Sandra; Tomljenović Paravić, Andrea; Sedić, Mirela; Pavelić, Krešimir; Mintas, Mladen.
The new 5- or 6-azapyrimidine and cyanuric acid derivatives of L-ascorbic acid bearing the free C-5 hydroxy or C-4 amino group at the ethylenic spacer: CD-spectral absolute configuration determination and biological activity evaluations Poster International Symposium on Advances in Synthetic and Medicinal Chemistry St. Petersburg - 1.1.2011.
5.
Wittine, Karlo; Stipković-Babić, Maja; Košutić, Marija; Mintas, Mladen.
Sinteza novih pirimidinskih derivata L-askorbinske kiseline radi ispitivanja citostatskih djelovanja Poster XXII. Hrvatski skup kemičara i kemijskih inženjera Zagreb - 1.1.2011.

Znanstveni projekti

1. 1.1.2009. - 1.1.2011.
Razvoj novih kemoterapeutika; Sinteza novih klasa spojeva; IRCRO; ;
2. 1.1.2007. - 1.1.2014.
Razvoj novih prolijekova i lijekova protiv virusa i raka ; Znanstveni novak, sinteza novih klasa spojeva; MZOŠ; ;
3. 1.1.2002. - 1.1.2005.
Razvoj novih terapijskih i dijagnostičkih supstancija za gensku terapiju raka; Volonter i znanstveni novak, sinteza novih klasa spojeva; MZOŠ; ;

Stručna djelatnost