Doc. dr. sc. Ivana Munitić

Odjel za biotehnologiju Zavod za molekularnu i sistemsku biomedicinu

e-pošta : ivana.munitic@biotech.uniri.hr
mobitel :
prostorija : Odjel za Biotehnologiju, Sveučilište u Rijeci, Radmile Matejčić, O-220
telefon : 385 51 584 579
prostorija : O-236-laboratorij, telefon: 385 51 584 582

Ivana Munitić/ Google scholar

Obrazovanje

1.1.2004. - 1.1.2006. Doktorat znanosti iz područja imunologije Ph.D. University René Descartes-Paris 5, Paris, France.
1.1.1991. - 1.1.1997. Doktor medicine Studij medicine Medicinski Fakultet Sveučilišta u Zagrebu

Radno iskustvo

1.1.2013. - Docent; voditelj laboratorija Docent na Odjelu za Biotehnologiju Sveučilišta u Rijeci. Voditelj Laboratorija za molekularnu imunologiju. Sveučilište u Rijeci
1.1.2009. - 1.1.2012. Postdoktorand Gostujući znanstvenik (research fellow), Laboratory of Immune Cell Biology. National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
1.1.2005. - 1.1.2009. Postdoktorand Gostujući znanstvenik, INSERM U591- Différenciation thymique et physiologie des lymphocytes T. Hôpital Necker, Paris, France.
1.1.2000. - 1.1.2004. Postdoktorand Gostujući znanstvenik (visiting fellow), Laboratory of Immune Cell Biology. National Cancer Institute, National Institutes of Health. Bethesda, MD.USA.
1.1.1998. - 1.1.1999. Znanstveni novak Znanstveni novak na Katedri za Patofiziologiju. Medicinski Fakultet, Sveučilišta u Zagrebu.
1.1.1997. - 1.1.1998. Liječnički staž Obavezni liječnički staž Bolnica Merkur, Zagreb

Nagrade i priznanja

Rektorova nagrada, Sveučilišta u Zagrebu.
Fogarty International Fellowship, USA.
Marie Curie Incoming Fellowship, European Union.

Članstva

1.1.2015. - Hrvatsko društvo za neuroznanost
1.1.2014. - Hrvatsko društvo za biokemiju i molekularnu biologiju (HDBMB)
1.1.2014. - American Association of Immunologists (AAI)
1.1.2013. - European Federation of Immunological Societies (EFIS)
1.1.2013. - Hrvatsko imunološko društvo (HID)

Nastavna djelatnost

Kolegiji

- Metodologija znanstveno-istraživačkog rada
Doktorski studij «Medicinska kemija»
Odjel za Biotehnologiju, Sveučilište u Rijeci
voditelj
Norma sati: 30
- Patofiziologija
Studij medicine
Medicinski Fakultet Sveučilišta u Zagrebu.
suradnik
Norma sati: 300
- Uvod u istraživački rad
Studij biotehnologije.
Odjel za Biotehnologiju, Sveučilište u Rijeci
voditelj
Norma sati: 100
- Imunoterapija
Studij biotehnologije.
Odjel za Biotehnologiju, Sveučilište u Rijeci
voditelj
Norma sati: 80
- Imunologija
Studij biotehnologije.
Odjel za Biotehnologiju, Sveučilište u Rijeci
voditelj
Norma sati: 120
- Capstone Course in Pathophysiology
University of Minnesota Summer School zajedno s Odjelom za Biotehnologiju
Odjel za Biotehnologiju, Sveučilište u Rijeci
suradnik
Norma sati: 4
- Fiziologija i patofiziologija
Studij biotehnologije.

suradnik
Norma sati: 10
- Uvod u Istraživački rad
Studij Biotehnologije
Odjel za Biotehnologiju, Sveučilište u Rijeci
suradnik
Norma sati: 8
- Neuroimunologija
Studij Biotehnologije
Odjel za Biotehnologiju, Sveučilište u Rijeci
voditelj
Norma sati: 30
- Neuroscience
Studij biotehnologije
Odjel za Biotehnologiju, Sveučilište u Rijeci
suradnik
Norma sati: 17

Mentor u završnim radovima

- Uloga mikroglije u amiotrofičnoj lateralnoj sklerozi
Marina Rumora
Preddiplomski sveučilišni studij "Biotehnologija i istraživanje lijekova"
Odjel za biotenologiju
- Uloga optineurina u NF-?B i TBK1 signalnim putevima
Mia Jakopović
Diplomski studij "Biotehnologija u medicini"
Odjel za biotenologiju
- Istraživanje uloge optineurina prilikom procesa autofagije
Tereza Ljutić
Diplomski studij "Medicinska kemija"
Odjel za biotenologiju
- Characterization of neuroinflammation in neuronal and microglial cell lines lacking optineurin
Alicia Pliego Mendieta
Erasmus dolazak s Universidad Europea Madrid
Odjel za biotenologiju i Universidad Europea Madrid
- IMMUNOTHERAPEUTIC APPROACHES FOR ALZHEIMERS DISEASE
Klara Krpina
Preddiplomski sveučilišni studij "Biotehnologija i istraživanje lijekova"
Odjel za biotenologiju
- IMMUNOTHERAPEUTIC APPROACHES FOR ALZHEIMERS DISEASE
Karlo Mladenić
Preddiplomski sveučilišni studij "Biotehnologija i istraživanje lijekova"
Odjel za biotenologiju
- ANALYSIS OF T FOLLICULAR HELPER CELL DEVELOPMENT IN THE CONTEXT OF VIRAL INFECTIONS
Vendi Šinkovec
Diplomski studij "Biotehnologija u medicini"; opaska: komentorstvo s dr. M. Kuka (San Raffalle Hospital, Milano)
Odjel za biotenologiju
- Analiza autofagije u staničnoj liniji Neuro 2a s CRISPR/Cas9 posredovanom delecijom optineurina
Nikolina Prtenjača
Diplomski studij "Biotehnologija u medicini"
Odjel za biotenologiju
- Characterizing the role of optineurin in inflammatory signaling in microglial and neuronal cell lines
Matea Rob
Diplomski studij "Biotehnologija u medicini"
Odjel za biotenologiju

Osobni razvoj

1.1.2015. - Advanced BD FACSAriaTM III Operator Training


Norma sati:
1.1.2008. - In Vivo Non-Linear Microscopy - Foundations and Applications.


Norma sati:
1.1.2004. - Vaccines.


Norma sati:
1.1.2002. - Molecular and Cellular Mechanisms of Immunity II.


Norma sati:
1.1.2000. - Molecular and Cellular Mechanisms of Immunity.


Norma sati:
1.1.1998. - Summer School on Molecular Medicine.


Norma sati:
1.1.1990. - Advanced English Course.


Norma sati:

Znanstvena i umjetnička djelatnost

Znanstveni radovi

1. Markovinovic A, Ljutic T, Béland LC, and Munitic I.
Optineurin Insufficiency Disbalances Proinflammatory and Anti-inflammatory Factors by Reducing Microglial IFN-ß Responses.
Neuroscience - 2018.

Q1

2. Markovinovic, A Cimbro, R Ljutic, T Kriz, J Rogelj, B Munitic, I
Optineurin in amyotrophic lateral sclerosis: Multifunctional adaptor protein at the crossroads of different neuroprotective mechanisms.
Progress in Neurobiology 154 1-20 - 2017. https://www.ncbi.nlm.nih.gov/pubmed/28456633

Q1

3. Malatesti, N Munitic, I Jurak, I
Porphyrin-based cationic amphiphilic photosensitisers as potential anticancer, antimicrobial and immunosuppressive agents.
Biophysical Reviews 9 149-168 - 2017. https://www.ncbi.nlm.nih.gov/pubmed/28510089

4. Pourcelot M, Zemirli N, Silva Da Costa L, Loyant R, Garcin D, Vitour D, Munitic I, Vazquez A, and Arnoult, D.
Golgi apparatus acts as a platform for TBK1 activation after viral RNA sensing.
BMC Biology 14 69 - 2016. https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-016-0292-z

Q1

5. Meena N.P., Zhu G., Mittelstadt P.R., Giardino Torchia M.L., Pourcelot M., Arnoult D., Ashwell J.D. and Munitic I.
The TBK1-binding domain of optineurin promotes type I interferon responses.
FEBS Letters 590 1498-1508 - 2016. http://www.ncbi.nlm.nih.gov/pubmed/27086836

Q1

6. MLG Torchia, I Munitic, E Castro, J Herz, DB McGavern, JD Ashwell
c-IAP ubiquitin protein ligase activity is required for 4-1BB signaling and CD8+ memory T-cell survival
European Journal of Immunology - 2015. http://www.ncbi.nlm.nih.gov/pubmed/?term=c-IAP+ubiquitin+protein+ligase+activity+is+required+for+4-1BB+signaling+and+CD8%2B+memory+T-cell+survival.

Q1

7. Li C.C., Munitic I., Mittelstadt P.R., Castro E. and Ashwell J.D.
Suppression of Dendritic Cell-Derived IL-12 by Endogenous Glucocorticoids Is Protective in LPS-Induced Sepsis
PLoS Biology 13 - 2015. http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1002269

Q1

8. Munitic, I*, Giardino Torchia, ML, Meena NP, Zhu G, Li CC, Ashwell, JD*. * Corresponding authors.
Optineurin Insufficiency Impairs IRF3 but not NF-?B Activation in Immune Cells.
The Journal of Immunology, 1301696 (Epub Nov 15) - 2013. http://www.jimmunol.org/content/early/2013/11/15/jimmunol.1301696.abstract

Q1

9. Kuka, M*, Munitic, I*, Giardino Torchia, ML, Ashwell, JD. *These authors contributed equally to this manuscript.
CD70 is downregulated by interaction with CD27.
The Journal of Immunology. 191 2282-9 - 2013. http://www.jimmunol.org/content/191/5/2282.abstract?sid=986a0595-f024-496b-a83d-c65be95581da

Q1

10. Munitic, I, Kuka, M, Allam A, Scoville JP, Ashwell, JD.
CD70 Deficiency Impairs Effector CD8 T Cell Generation and Viral Clearance but Is Dispensable for the Recall Response to Lymphocytic Choriomeningitis Virus.
Journal of Immunology. 190 1169-79. - 2013. http://www.jimmunol.org/content/190/3/1169.abstract?sid=986a0595-f024-496b-a83d-c65be95581da

Q1

11. Kuka, M, Munitic, I, Ashwell, JD.
Identi?cation and characterization of polyclonal ?ß-T cells with dendritic cell properties.
Nature Communications. 1223 - 2012. http://www.ncbi.nlm.nih.gov/pubmed/23187623

Q1

12. Munitic, I, Evaristo, C, Sung, HC, Rocha, B.
Transcriptional regulation during CD8 T-cell immune responses.
Advances in Experimental Medicine and Biology 11-27 - 2010. http://www.ncbi.nlm.nih.gov/pubmed/20795537

13. Decaluwe, H, Taillardet, M, Corcuff, E, Munitic, I, Law, HK, Rocha, B, Riviere, Y, Di Santo, JP.
Gamma(c) deficiency precludes CD8+ T cell memory despite formation of potent T cell effectors.
Proceedings of the National Academy of Sciences (PNAS) 107(20) 311-6 - 2010. http://www.ncbi.nlm.nih.gov/pubmed/20439728

Q1

14. Munitic I*, Decaluwe, H, Evaristo, C, Lemos, S, Wlodarczyk, M, Worth, A, Le Bon, A, Selin, LK, Riviere, Y, Di Santo, JP, Borrow, P, Rocha, B*. * Corresponding authors.
Epitope specificity and relative clonal abundance do not affect CD8 differentiation patterns during lymphocytic choriomeningitis virus infection.
Journal of Virology 83 11795-807. - 2009. http://www.ncbi.nlm.nih.gov/pubmed/19726518

Q1

15. Allam, A, Conze, DB, Giardino Torchia, ML, Munitic, I, Yagita, H, Sowell, RT, Marzo, AL, Ashwell, JD.
The CD8+ memory T-cell state of readiness is actively maintained and reversible.
Blood 114 2121-30. - 2009. http://www.ncbi.nlm.nih.gov/pubmed/19617575

Q1

16. Peixoto A, Evaristo C, Munitic I, Monteiro M, Charbit A, Rocha B. Veiga-Fernandes H.
CD8 single-cell gene co-expression reveals three different effector types present at distinct phases of the immune response.
Journal Experimental Medicine 204 1193-205. - 2007. http://www.ncbi.nlm.nih.gov/pubmed/17485515

Q1

17. Munitic I, Ryan PE and Ashwell, JD.
T cells in G1 provide a memory-like response to secondary stimulation.
Journal of Immunology 174 4010-8. - 2005. http://www.ncbi.nlm.nih.gov/pubmed/15778358

Q1

18. Munitic I, Williams JA, Yang Y, Dong B, Lucas PJ, El Kassar N, Gress RE, and Ashwell JD.
Dynamic regulation of IL-7 receptor expression is required for normal thymopoiesis.
Blood 104 4165-72. - 2004. http://www.ncbi.nlm.nih.gov/pubmed/15328149

Q1

19. Oro U*, Munitic I*, Chacko G, Karpova T, McNally J, Ashwell JD. *These authors contributed equally to this manuscript.
Regulation of constitutive T cell receptor internalization by the ? chain.
Journal of Immunology 169 6269-78. - 2002. http://www.ncbi.nlm.nih.gov/pubmed/12444133

Q1

Pozvana predavanja

1. I. Munitić
Cijepljenje: znanstvene i etičke dimenzije; Filozofski fakultet Sveučilišta u Rijeci
Rijeka - 10.5.2018.
2. I. Munitić
Razvoj novih životinjskih modela za istraživanje amiotrofične lateralne skleroze; Godišnja skupština Hrvatskog društva za znanost o laboratorijskim životinjama (CroLASA),.
Institut Ruđer Bošković, Zagreb - 2.2.2018.
3. I. Munitić
Animal Models of Amyotrophic Lateral Sclerosis; Croatian National Academy of Sciences and Arts 1st Rijeka Forum on Neurodegenerative Diseases, Rijeka,Croatia.
Rijeka - 17.10.2017.
4. I. Munitić
Elucidating the role of optineurin in amyotrophic lateral sclerosis; Laval University, CERVO Brain, Research Centre Quebec City, Canada.
Quebec City, Canada - 19.9.2017.
5. I. Munitić
Characterization of the role of optineurin in neurodegeneration, 13th Symposium of the André-Delambre Foundation, Montreal, Canada.
Montreal, Canada - 16.9.2017. http://www.fondationandredelambre.com/html/symposiumeng.html
6. I. Munitić
Molecular characterization of mouse optineurin insufficiency models; Regional meeting of clinicians and basic scientists that work on ALS, Ljubljana, Slovenia.
Ljubljana - 12.5.2017.
7. Ivana Munitić
Istraživanje uloge optineurina u neuroprotekciji, Rijeka, travanj 2017, Predstavljanje uspostavnog istraživačkog projekta Hrvatske zaklade za znanost (HRZZ).
Medicinski fakultet, Rijeka - 25.4.2017.
8. Ivana Munitić
Symposium: Translation of Basic Immunology and Neuroscience Tools to Therapies: Where are We Now?; Croatian Academy for Sciences and Arts and Department of Biotechnology. Talk title: Animal models for elucidating the role of adaptor protein optineurin during inflammation.
Odjel za biotehnologiju, Rijeka. - 4.7.2016. http://symposium-neuroimmunology.uniri.hr
9. Ivana Munitić
Tribina HAZU, KBC – HLZ Podružnica Rijeka: "NOVIJA POSTIGNUĆA U IMUNOLOGIJI I HEMATOLOGIJI" Naslov predavanja: Nove funkcije dendritičkih stanica.
Rijeka, Hrvatska. - 14.10.2014.
10. Ivana Munitić
10th Symposium of the André-Delambre Foundation, Amyotrophic Lateral Sclerosis: Causes and Therapeutic Perspectives. Naslov predavanja: A Mouse Model of Optineurin Insufficiency
Montreal, Canada. - 1.9.2014.
11. Ivana Munitić
Iskustva i izazovi istraživača u biomedicini
Filozofski fakultet Sveučilišta u Rijeci

Kongresna priopćenja

1.
Munitic I, Markovinovic A, and Ashwell JD.
An optineurin insufficiency model of ALS. odabrano usmeno izlaganje ENCALS (European Network for the Cure of ALS) meeting. Milano, Italy. - 1.1.2016.
2.
Markovinović A, Barukčić A, Jakopović M, Šinkovec V, Jakovac H, Grabušić K, Ashwell JD, and Munitić I.
An optineurin insufficiency model as a potential tool for elucidating the pathogenesis of amyotrophic lateral sclerosis. poster Croatian Society for Neuroscience meeting. Split, Croatia. - 1.1.2015.
3.
Munitic I, Giardino Torchia ML, and Ashwell JD.
Optineurin is dispensable for LPS- and Salmonella typhimurium-induced autophagy. poster American Associations of Immunologists Annual Meeting. New Orleans, USA. - 1.1.2015.
4.
Munitic I, Li CC, Mittelstadt PR, Castro E, and Ashwell JD.
Endogenous glucocorticoids suppress dendritic cell-derived IL-12 and prevent death in LPS-induced sepsis, Selected Oral presentation. odabrano usmeno izlaganje 4th European Congress of Immunology. Vienna, Austria. - 1.1.2015.
5.
Munitic I, Giardino Torchia ML, Meena NP, and Ashwell JD.
Optineurin is a Positive Regulator of IFN-ß. odabrano usmeno izlaganje Annual meeting of the Croatian Imunological Society. Krk, Croatia. - 1.1.2014.
6.
Munitic I, Giardino Torchia ML, Meena NP, and Ashwell JD.
Optineurin is Indispensible for Signaling via IRF3 but not NF-?B Activation Pathway. poster 2nd Meeting on Middle-European Societies for Immunology and Allergology. Opatija, Croatia. - 1.1.2013.
7.
Munitic I, Giardino Torchia ML, Meena NP, and Ashwell JD.
A Mouse Model of Optineurin Insufficiency Exhibits Impaired Signaling via IRF3 but not NF-?B Activation Pathway. poster 4th Croatian Neuroscience Congres. Zagreb, Croatia. - 1.1.2013.
8.
Tereza Ljutić, Andrea Markovinović, Sai Sampath Thammisetty, Jasna Križ, Ivana Munitić.
Characterization of the optineurin insufficiency mouse model. poster Scientific poster day of CERVO Institute. Quebec city, Canada.
9.
Andrea Markovinović, Tereza Ljutić i Ivana Munitić
Molecular characterization of mouse optineurin insufficiency models. poster European Network for the Cure for ALS (ENCALS) meeting Ljubljana, Slovenija.
10.
Hrvoje Jakovac, Andrea Markovinovic and Ivana Munitic
Characterization of neurodegeneration in an optineurin insufficiency mouse model. poster Annual Meeting Of The Croatian Immunological Society With EFIS On Tour Zagreb, Croatia
11.
Andrea Markovinović, Tereza Ljutić, Milojević i Ivana Munitić
Characterization of the role of optineurin in neurodegeneration. poster Young Neuroscientists Meeting (YMN) Zagreb, Croatia
12.
Hrvoje Jakovac, Andrea Markovinovic and Ivana Munitic
Neurohistopathological characterization of an optineurin insufficiency mouse model. poster Congress of Croatian Physiological Society and Regional Congress of the Physiological Societies Dubrovnik, Croatia
13.
Andrea Markovinović, Tereza Ljutić, Milojević i Ivana Munitić
Characterization of the role of optineurin in neuroinflammation. poster Atypical dementias: from diagnosis to emerging therapies Trst, Italija.
14.
Munitic I, Markovinovic A, and Ashwell JD.
An optineurin insufficiency model of ALS. usmena prezentacija ENCALS (European Network for the Cure of ALS) meeting Milano, Italy

Znanstveni projekti

1. 1.10.2018. - 30.9.2022.
Controlling neurodegeneration by modulating the crosstalk between inflammation and proteinopathy; voditelj; HRZZ; 1.000.000, 00 kn; u izradi
2. 1.1.2014. - 1.1.2017.
Elucidating the Role of Optineurin in Neuroprotection. ; voditelj; Hrvatska Zaklada za Znanost; 1,000,000 kn; http://www.optineurin-neuroimmunology.uniri.hr

Mentorstvo doktorandima

1. 1.1.2015. - 1.1.2019.
Andrea Markovinović; Doktorat radni naslov: Neuroprotektivna uloga optineurina. ; Medicinska kemija; ;
2. 1.1.2015. -
Mia Jakopović; Doktorat još neodređeno; Medicinska kemija; još neodređeno; radi se o studiju uz rad;

Znanstveni skupovi

1. 7.5.2018. - 7.5.2018.
2nd Meeting Of Basic Researchers And Clinicians Working On ALS (SLO/HR) Odjel za biotehnologiju, Rijeka organizator
2. 30.6.2016. -
International symposium for young neuroscience researchers: 20th Young Neuroscientists Meeting. Odjel za biotehnologiju, Rijeka, Croatia. ko-organizator (glavni organizator Miranda Mladinić Pejatović)
3. - 5.7.2016.
Simpozij u organizaciji HAZU i Odjela za biotehnologiju (iz projekta voditeljice projekta, I. Munitić): TRANSLATION OF BASIC IMMUNOLOGY AND NEUROSCIENCE TOOLS TO THERAPIES:Where Are We Now? Rijeka suorganizator (član znanstvenog odbora i predsjednik organizacijskog odbora)

Uredništva časopisa

1. - Gostujući urednik za časopis Frontiers in Immunology; tema: The Role of Optineurin in Immunity and Immune-Mediated Diseases.
https://www.frontiersin.org/research-topics/6554/the-role-of-optineurin-in-immunity-and-immune-mediated-diseases

Recenzije

1. Recenzent programa cjeloživotnog učenja (Sveučilište u Rijeci)
2. HRZZ recenzent

Javno djelovanje

Popularizacija znanosti

1. - Predavanje: Mikroglija i ALS, te demonstracija: Određivanje krvnih grupa
Otvoreni dan odjela za biotehnologiju
Odjel za biotehnologiju, Sveučilište u Rijeci
2. - Plenarno predavanje: Imuni nadzor mozga, te Otvorena vrata laboratorija
Otvoreni dan odjela za biotehnologiju
Odjel za biotehnologiju, Sveučilište u Rijeci
3. - Igrokaz: Tko je jači: Imuni sustav ili virusi?
Otvoreni dan odjela za biotehnologiju
Odjel za biotehnologiju, Sveučilište u Rijeci
4. - Organizacija Otvorenog dana; Igrokaz: Tko je jači: Imuni sustav ili virusi?
Otvoreni dan odjela za biotehnologiju
Odjel za biotehnologiju, Sveučilište u Rijeci
5. - Predavanje: Cijepljenje - najučinkovitija obrana protiv zaraznih bolesti
Baltazar na Gradini
Trsatska Gradina
6. - Predavanje: Cijepljenje - znanstvene dimenzije
Dani Filozofskog fakulteta; tribina: Cijepljenje - znanstvene i etičke dimenzije
Filozofski fakultet Sveučilišta u Rijeci