dr. sc. Antonija Jurak Begonja

Odjel za biotehnologiju Zavod za molekularnu i sistemsku biomedicinu
Odjel za biotehnologiju Zavod za molekularnu i sistemsku biomedicinu

prostorija : O-224
e-pošta : ajbegonja@biotech.uniri.hr
telefon : +385 51 584 581

MEĐUNARODNA VIDLJIVOST:
CITATIH-INDEXI10-INDEX
Google Scholar 829 13 15
Web of Science 509 12

Obrazovanje

1.9.2003. - 30.3.2007. Dr. sc. Prirodne znanosti Fakultet kemije i farmacije, Julius-Maximilians Sveučilište u Wuerzburgu, Njemačka
1.9.1994. - 30.3.2000. Diplomirani inženjer medicinske biokemije Medicinska biokemija Farmaceutsko-biokemijski fakultet, Sveučilište u Zagrebu

Radno iskustvo

1.6.2013. - Docent Istraživanje molekularnih mehanizama razvoja trombocita; nastavna aktivnost (kolegij "Biologija matičnih stanica") Odjel za biotehnologiju, Sveučilište u Rijeci
1.5.2007. - 1.6.2013. Poslijedoktorand Istraživanje uloge citoskeleta u razvoju megakariocita i trombocita, u laboratoriju prof. John H. Hartwig-a Brigham and Women's Hospital, Harvard Medical School, Boston, SAD
1.1.2004. - 30.3.2007. Doktorand Doktorski studij, istraživanje signalnih puteva (ROS, cAMP, cGMP) u funkciji trombocita, mentori prof. Ulrich Walter i dr. Stepan Gambaryan Institut für Klinische Biochemie und Pathobiochemie, Julius-Maximilians Sveučilište u Würzburgu, Njemačka
1.2.2001. - 31.12.2003. Znanstveni novak Istraživanje povezanosti određenih polimorfizama sa bolestima krvožilja (association studies) pod mentorstvom prof. Elizabete Topić Klinički zavod za kemiju, KB "Sestre milosrdnice", Zagreb
1.5.2000. - 1.1.2001. Stažist-volonter Odrađivanje obaveznog radnog staža medicinske biokemije i laboratorijske hematologije, državni ispit položen u prosincu 2001. Klinički zavod za kemiju, KB "Sestre milosrdnice", Zagreb
1.1.1999. - Diplomant Izrada diplomskog rada o učinku ohratoksina A na apoptozu i citoskelet bubrežnih staničnih linija, mentor prof. Karmele Barišić Zavod za medicinsku biokemiju, Farmaceutsko-biokemisjki fakultet, Sveučilište u Zagrebu

Nagrade i priznanja

23.9.2016. Scientific Award for Poster Presentation "PI3P regulates proplatelet formation in vitro", 3rd European Platelet Network Conference (EUPLAN) 2016
1.1.2014. NEWFELPRO fellowship (Marie Curie FP7-PEOPLE-2011-COFUND) (2 godine)
1.12.2010. American Society of Hematology Travel Award
1.4.2001. CEEPUS stipendija, Odjel za biokemiju, Fakultet farmacije, Karlovo sveučilište, Hradec Kralove, Republika Češka (2 mj)
1.3.1999. CEEPUS stipendija, Institut za kliničku kemiju, Pečuh, Mađarska (1 mj)
1.1.1999. Rektorova nagrada
1.1.1997. Stipendija Sveučilišta u Zagrebu (1 godina)
1.1.1995. Stipendija grada Zadra (5 godina)

Članstva

1.1.2015. - Biochemical Society
1.1.2007. - International Society on Thrombosis and Haemostasis
1.1.2002. - Hrvatsko društvo biokemije i molekularne biologije
1.1.2001. - Hrvatsko društvo medicinskih biokemičara

Nastavna djelatnost

Kolegiji

12.6.2017. - 13.6.2017. Uvod u znanstveni rad
Doktorski studij Medicinska kemija
Odjel za biotehnologiju
suradnik
Norma sati:
1.1.2015. - Opća fiziologija i patofiziologija
Istraživanje i razvoj lijekova
Odjel za biotehnologiju
voditelj
Norma sati:
1.1.2014. - Imunologija
Biotehnologija i istraživanje lijekova
Odjel za biotehnologiju
suradnik
Norma sati:
1.1.2013. - Biologija matičnih stanica
Biotehnologija i istraživanje lijekova
Odjel za biotehnologiju
voditelj
Norma sati:
1.1.2013. - Uvod u istraživački rad

Odjel za biotehnologiju
suradnik
Norma sati:

Mentor u završnim radovima

1.2.2016. - 26.9.2016. Kloniranje, mutageneza i karakterizacija fosfatidilinozitol 3-monofosfat vezujućih domena u HEK293T i primarnim megakakriocitima
Paola Paškvan
Biotehnologija u medicini
Odjel za biotehnologiju
1.10.2015. - 22.9.2016. Uloga fosfoinozitida u membranskom unutarstaničnom prometu
Ana Bura
Istraživanje i razvoj lijekova
Odjel za biotehnologiju
1.10.2015. - 22.9.2016. Molekularni mehanizmi nastajanja trombocita
Iris Car
Istraživanje i razvoj lijekova
Odjel za biotehnologiju
28.9.2015. - Ekspresija i funkcija Vps34 u nastanku protrombocita
Marija Banović
Biotehnologija u medicini
Odjel za biotehnologiju
14.7.2015. - Regulacija prometa receptora filaminom A
Marta Ursić
Biotehnologija i istraživanje lijekova
Odjel za biotehnologiju
1.2.2014. - 1.6.2014. Uloga filamina A u lokalizaciji trombopoetinskog receptora u primarnim mišjim megakariocitima
Romina Sabo
Istraživanje i razvoj lijekova
Odjel za biotehnologiju

Gostujući nastavnik

- 9.5.2014.
Biotehnologija, farmacija
Fakultet biomedicinskih znanosti, Universidad Europea Madrid, Španjolska
suradnik
Norma sati: 12

Znanstvena i umjetnička djelatnost

Znanstveni radovi

1. Marecic V, Shevchuk O, Ozanic M, Mihelcic M, Steinert M, Jurak Begonja A, Abu Kwaik Y, Santic M.
Isolation of F. novicida-containing phagosome from infected human monocyte derived macrophages.
Frontiers in Cellular and Infection Microbiology. - 2017.

Q1
WOS

2. Grozovsky, Renata; Jurak Begonja, Antonija; Liu, Kaifeng; Visner, Gary; Falet, Herve; Hartwig, John H; Hoffmeister, Karin M
The Ashwell-Morell receptor regulates hepatic thrombopoietin production via JAK2-STAT3 signaling.
Nature Medicine 21 47-54. - 2015. http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.3770.html

Q1
WOS
Exc

3. Jurak Begonja A, Pluthero FG, Suphamungmee W, Giannini S, Christensen H, Leung R, Lo RW, Nakamura F, Lehman W, Plomann M, Hoffmeister KM, Kahr WH, Hartwig JH, Falet H.
FlnA binding to PACSIN2 F-BAR domain regulates membrane tubulation in megakaryocytes and platelets.
Blood Blood. 2015 Apr 2. pii: blood-2014-07-587600. [Epub ahead of print] - 2015. http://www.ncbi.nlm.nih.gov/pubmed/25838348

Q1
WOS

4. Giannini S, Adelman M, Jurak Begonja A, Hoffmeister K
CXCL12/SDF-1 Stimulates Megakaryocyte ß-1,4-Galactosyltransferase 1 Activity to Enhance Platelet Production in Vivo.
The FASEB Journal 29 719-22 - 2015. http://www.fasebj.org/content/29/1_Supplement/719.22.short

Q1

5. Begonja AJ
Molecular mechanisms of megakaryocyte and platelet development.
RAD Medical Sciences, journal of Croatian Academy of Sciences and Arts. 42 35-47 - 2015.

6. Thon, Jonathan N; Macleod, Hannah; Begonja, Antonija Jurak; Zhu, Jie; Lee, Kun-Chun; Mogilner, Alex; Hartwig, John H; Italiano Jr, Joseph E;
Microtubule and cortical forces determine platelet size during vascular platelet production
Nature Communications 3 852 - 2012.

Q1
WOS

7. Begonja, Antonija Jurak; Gambaryan, Stepan; Schulze, Harald; Patel-Hett, Sunita; Italiano Jr, Joseph E; Hartwig, John H; Walter, Ulrich;
Differential roles of cAMP and cGMP in megakaryocyte maturation and platelet biogenesis
Experimental Hematology - 2012.

Q1
WOS

8. Thon, Jonathan N; Devine, Matthew T; Begonja, Antonija Jurak; Tibbitts, Jay; Italiano, Joseph E;
High-content live-cell imaging assay used to establish mechanism of trastuzumab emtansine (T-DM1)–mediated inhibition of platelet production
Blood 120 1975-1984 - 2012.

Q1
WOS

9. Begonja, Antonija Jurak; Hoffmeister, Karin M; Hartwig, John H; Falet, Hervé;
FlnA-null megakaryocytes prematurely release large and fragile platelets that circulate poorly
Blood 118 2285-2295 - 2011.

Q1
WOS

10. Patel-Hett, Sunita; Wang, Hongbei; Begonja, Antonija J; Thon, Jonathan N; Alden, Eva C; Wandersee, Nancy J; An, Xiuli; Mohandas, Narla; Hartwig, John H; Italiano, Joseph E;
The spectrin-based membrane skeleton stabilizes mouse megakaryocyte membrane systems and is essential for proplatelet and platelet formation
Blood 118 1641-1652 - 2011.

Q1
WOS

11. Falet, Hervé; Pollitt, Alice Y; Begonja, Antonija Jurak; Weber, Sarah E; Duerschmied, Daniel; Wagner, Denisa D; Watson, Steve P; Hartwig, John H;
A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function
The Journal of experimental medicine 207 1967-1979 - 2010.

Q1
WOS

12. Rukoyatkina, Natalia; Begonja, Antonija J; Geiger, Jörg; Eigenthaler, Martin; Walter, Ulrich; Gambaryan, Stepan;
Phosphatidylserine surface expression and integrin ?IIbß3 activity on thrombin/convulxin stimulated platelets/particles of different sizes
British journal of haematology 144 591-602 - 2009.

Q1
WOS

13. Begonja, Antonija Jurak; Geiger, Jörg; Rukoyatkina, Natalia; Rauchfuss, Steffen; Gambaryan, Stepan; Walter, Ulrich;
Thrombin stimulation of p38 MAP kinase in human platelets is mediated by ADP and thromboxane A2 and inhibited by cGMP/cGMP-dependent protein kinase
Blood 109 616-618 - 2007.

Q1
WOS

14. Begonja, Antonija J; Teichmann, Lino; Geiger, Jörg; Gambaryan, Stepan; Walter, Ulrich;
Platelet regulation by NO/cGMP signaling and NAD (P) H oxidase-generated ROS
Blood Cells, Molecules, and Diseases 36 166-170 - 2006.

Q1
WOS

15. Zahedi, René P; Begonja, Antonija J; Gambaryan, Stepan; Sickmann, Albert;
Phosphoproteomics of human platelets: A quest for novel activation pathways
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1764 1963-1976 - 2006.

Q1
WOS

16. Begonja, Antonija Jurak; Gambaryan, Stepan; Geiger, Jörg; Aktas, Barsom; Pozgajova, Miroslava; Nieswandt, Bernhard; Walter, Ulrich;
Platelet NAD (P) H-oxidase–generated ROS production regulates ?IIbß3-integrin activation independent of the NO/cGMP pathway
Blood 106 2757 - 2005.

Q1
WOS

17. Gambaryan, Stepan; Geiger, Jörg; Schwarz, Ulrike R; Butt, Elke; Begonja, Antonija; Obergfell, Achim; Walter, Ulrich;
Potent inhibition of human platelets by cGMP analogs independent of cGMP-dependent protein kinase
Blood 103 2593-2600 - 2004.

Q1
WOS

18. Šimundić, Ana-Maria; Bašić, Vanja; Topić, Elizabeta; Demarin, Vida; Vrkić, Nada; Kunović, Branka; Štefanović, Mario; Begonja, Antonija
Soluble adhesion molecules in acute ischemic stroke
Clinical & investigative medicine (0147-958X) 27 (2004), 2; 86-92 27 86-92 - 2004.

Q1
WOS

19. Žuntar, Irena; Topić, Elizabeta; Vukosavić, Đuro; Vuković, Vlasta; Demarin, Vida; Begonja, Antonija; Antoljak, Nataša; Šimundić, Ana Maria
Croatian population data for the C677T polymorphism in methylenetetrahydrofolate reductase: frequencies in healthy and atherosclerotic study groups
Clinica chimica acta (0009-8981) 335 (2003); 95-100 335 95-100 - 2003.

Q2
WOS

20. Begonja, Antonija; Šimundić, Ana-Maria; Štefanović, Mario; Topić, Elizabeta;
PCR-SSCP genotipizacija polimorfizma 4G/5G inhibitora-1 aktivatora plazminogena.
Biochem Med 12 1-5 - 2002.

Pozvana predavanja

1. Begonja AJ.
Platelet function, thrombopoiesis and immune thrombocytopenia.
Ljetna škola “Javno zdravstvo i patofiziologija” Saint Cloud State Sveučilište/USA & Odjel za biotehnologiju/Sveučilište u Rijeci. - 16.6.2017.
2. Begonja AJ.
Akademska karijera: međunarodno i domaće iskustvo.
Udruga studenata Biotehnologije, Odjel za biotehnologiju, Sveučilište u Rijeci - 8.12.2016.
3. Begonja AJ
Platelet function, thrombopoiesis and immune thrombocytopenia.
Joint St. Cloud State University/USA & Department of Biotechnology/University of Rijeka Summer School “Public health and pathophysiology”. Rijeka, Croatia - 17.6.2016.
4. Begonja AJ
Filamin A u regulaciji nastanka megakariocita.
HAZU 8. znanstvena tribina: biologija i patologija trombocita. Rijeka - 17.12.2015.
5. Antonija Jurak Begonja
From the biggest to the smallest: Filamin A regulates differentiation of megakaryocytes into platelets.
International Centre for Genetic Engineering and Biotechnology (ICGEB). Trieste, Italy. - 17.11.2015. http://www.icgeb.org/tl_files/seminars/Seminars%202015/2015%20Begonja.pdf
6. Begonja AJ
Platelet function, thrombopoiesis and immune thrombocytopenia.
Joint Saint Cloud State University/USA & Department of Biotechnology/University of Rijeka Summer School in Pathophysiology. Rijeka, Croatia - 26.6.2015.
7. Begonja AJ.
Molecular mechanisms of megakaryocyte and platelet development.
Croatian Academy of Science and Arts Symposium: Developmental biology of platelets, thrombocitopenia, and myeloproliferative neoplasms. Rijeka, Croatia. - 12.3.2015.
8. Begonja AJ, Grozovsky R, Hoffmeister KM, Falet H, Hartwig JH
Filamin A stabilizes thrombopoietin receptor surface expression and inhibits its degradation
2nd EUPLAN (European Platelet Network) Conference, Le Bischenberg, Francuska - 25.9.2014. http://euplan.eu/docs/Programme_final.pdf
9. Begonja AJ, Gambaryan S, Walter U.
Platelet Regulation by NAD(P)H Oxidase-Generated ROS and NO/cGMP Signaling.
Brigham and Women´s Hospital, Harvard Medical School, Boston, USA
10. Begonja AJ
New Insights on Mechanisms of Platelet Production.
3rd Congress of Croatian Physiological Society and 1st Regional Congress of the Physiological Societies, Rijeka, Croatia
11. Begonja AJ
Sva lica trombocita.
3. Tribina Hrvatske akademije znanosti i umjetnosti: Novija postignuća u imunologiji i hematologiji, Rijeka http://info.hazu.hr/zavod_ktimuno_molmed
12. Begonja AJ, Gambaryan S, Walter U.
Differential Mechanisms of Platelet ROS Production by Thrombin and Convulxin.
XXth European Platelet Meeting, Ede, Netherlands. October 14th 2005.
13. Begonja A, Bilopavlovic N, Petrik J, Barisic K, Juretic D.
Effect of Ochratoxin A on Cell Death and Intracellular ATP in Kidney RK-13 and LLC-PK1 Cells.
Summer University of Biochemistry, Zadar, Croatia
14. Begonja AJ
Filamin A and Thrombopoiesis.
Center for Thrombosis and Haemostasis, Mainz, Germany.
15. Begonja AJ
Razvojni put trombocita
Department of Biotechnology, University of Rijeka.
16. Begonja AJ
The many faces of filamin A in megakaryocytes
Institute for clinical biochemistry and pathobiochemistry, Wurzburg, Germany
17. Begonja AJ
Differental role of cAMP and cGMP in megakaryocyte differentiation from mouse fetal liver stem cells.
Children’s Hospital Boston, USA.
18. Begonja AJ, Gambaryan S, Walter U.
cGMP/cAMP Signaling in Megakaryocyte and Platelet Production.
SFB 688 Meeting, Wuerzburg, Germany.
19. Begonja AJ, Gambaryan S, Walter U.
Function of ROS in Platelets.
14th Virtual Platelet Meeting Club, Würzburg, Germany.
20. Begonja AJ
Role of Cyclic Nucleotides in Development of Megakaryocytes.
Croatian Society of Medical Biochemists, Split, Croatia.

Kongresna priopćenja

1.
Bertović I, Krauss M, Haucke V, Jurak Begonja A.
Phosphatidylinositol 3-monophosphate (PI3P) regulates megakaryocyte maturation and proplatelet formation. Poster FEBS/EMBO Advanced Lecture Course: Molecular Architecture, Dynamics and Function of Biomembranes Cargese, Korzika, Francuska - 14.6.2017.
2.
Bertović I, Krauss M, Haucke V, Jurak Begonja A.
Differential levels and localization of PI3P in immature and mature megakaryocytes. Poster Gordon Research Conference: Cell biology of megakaryocytes and platelets. Barga, Italy - 1.3.2017.
3.
Bertovic I, Banovic M, Paskvan P, Hartwig JH, Jurak Begonja A.
Jurak Begonja A. Phosphatidylinositol 3-monophosphate (PI3P) regulates proplatelet formation in vitro. Poster- Award for the best poster presentation 3rd EUPLAN (European Platelet Network) Conference Bad Homburg, Germany - 22.9.2016.
4.
Bertovic I, Jurak Begonja A.
Phosphatidylinositol 3-monophosphate (PI3P) is required for platelet production in vitro. Poster Croatian Academy of Sciences and Arts 14th Symposium: Translation of basic immunology and neuroscience tools to therapies; Rijeka, Croatia - 4.7.2016.
5.
Bertovic I, Banovic M, Hartwig JH, Jurak Begonja A.
Expression of PI3P binding phox (PX) domain inhibits megakaryocyte development into proplatelets. Poster Biochemical Society UK & FEBS, Signalling 2015: Cellular Functions of Phosphoinositides and Inositol Phosphates Cambridge, UK - 1.9.2015.
6.
Giannini S, Adelman M, Jurak Begonja A, Hoffmeister KM.
Beta galactosyltransferase (B4GALT1) is a key reggulator of hematopoetic stem cell function and thrombopoiesis. Oral International Society of Thrombosis and Hemostasis Congress (ISTH) Toronto, Canada - 20.6.2015. https://c.ymcdn.com/sites/www.isth.org/resource/resmgr/Microsite2/ISTH2015_Book_COMPLETE_Jun_0.pdf
7.
Giannini S, Adelman M, Begonja AJ, Mullally A, Hoffmeister KM.
Beta 1,4 Galactosyltransferase 1 is a key regulator of hematopoietic stem cell function and thrombopoiesis. Poster Gordon Research Conference: Cell Biology of Megakaryocytes & Platelets Barga, Italija - 20.4.2015.
8.
Grozovsky R, Begonja AJ, Hartwig JH, Falet H, Hoffmeister KM
The Ashwell-Morell Receptor Regulates Hepatic Thrombopoietin Production Via JAK2-STAT3 Signaling in Vivo and in Vitro. Plenarno predavanje 56th American Society of Hematology Meeting San Francisco, CA, SAD - 6.12.2014. https://ash.confex.com/ash/2014/webprogram/Paper75943.html
9.
Giannini S, Adelman M, Begonja AJ, Hoffmeister KM
Posttranslational Modification in Megakaryocytes Regulates ß1 Integrin Expression, Migration and Platelet Production in Vivo Poster 56th American Society of Hematology Meeting San Francisco, CA, SAD - 6.12.2014. https://ash.confex.com/ash/2014/webprogram/Paper75462.html
10.
Jönsson T, Pluthero F, Begonja AJ, Kormann J, Demers M, Wagner DD, Plomann M, Hartwig JH, Kahr WH, Falet H
The F-BAR Protein PACSIN2 Regulates Platelet Intracellular Membrane Architecture and in Vivo Hemostatic Functions Poster 56th American Society of Hematology Meeting San Francisco, CA, SAD - 6.12.2014. https://ash.confex.com/ash/2014/webprogram/Paper74596.html
11.
Giannini S, Jurak Begonja A, Adelmann M, Hoffmeister KM.
Aberrant Type-2-Lactosaminoglycan Synthesis Severely Impairs Thrombopoiesis Poster 55th American Society of Hematology Annual Meeting and Exposition New Orleans, LA, USA - 5.12.2013. http://bloodjournal.hematologylibrary.org/content/122/21/2320.abstract?sid=7ac21ce0-4dc1-434a-8409-a567b1ea87a7
12.
Hoffmeister KM, Grozovsky R, Begonja AJ, Hartwig JH.
The hepatic Ashwell-Morell receptor regulates thrombopoietin production. Talk International Society on Thrombosis and Haemostasis XXIV Congress Amsterdam, Netherlands - 29.6.2013.
13.
Begonja AJ, Grozovsky R, Hoffmeister KM, Falet H, Hartwig JH.
Filamin A regulates thrombopoietin c-Mpl receptor function. Poster Gordon Research Conference Galveston, TX, USA - 10.3.2013.
14.
Jönsson T, Begonja AJ, Bender M, Kim H, Kormann J, Merkl B, Pluthero F, Kahr WH, Hartwig JH, Plomann M, Falet H.
The F-BAR protein PACSIN 2 orchestrates the intracellular membrane architecture of platelets and megakaryocytes. Poster Gordon Research Conference Galveston, TX, USA - 10.3.2013.
15.
Giannini S, Adelman M, Begonja AJ, Hoffmeister KM.
Correct LacNAc synthesis is required for platelet production. Poster Gordon Research Conference Galveston, TX, USA - 10.3.2013.
16.
Grozovsky, Renata; Begonja, Antonija Jurak; Hartwig, John H; Hoffmeister, Karin M;
Clearance of Desialylated Platelets by the Hepatic Asialoglycoprotein Receptor Regulates TPO Homeostasis in Vivo Poster 54th American Society of Hematology Meeting Atlanta, USA - 5.12.2012. http://abstracts.hematologylibrary.org/cgi/content/abstract/120/21/2170?maxtoshow=&hits=10&RESULTFORMAT=&fulltext=begonja&searchid=1&FIRSTINDEX=0&volume=120&issue=21&resourcetype=HWCIT
17.
Thon JN, Macleod H, Begonja AJ, Zhu J, Lee KC, Mogilner A, Hartwig JH, Italiano JE.
Size Limits the Ability of Platelets to Undergo Abcission Online publication 53rd American Society of Hematology Meeting San Diego, USA - 9.12.2011. http://abstracts.hematologylibrary.org/cgi/content/abstract/118/21/4821?maxtoshow=&hits=10&RESULTFORMAT=&fulltext=begonja&searchid=1&FIRSTINDEX=0&volume=118&issue=21&resourcetype=HWCIT
18.
Begonja, Antonija Jurak; Nguyen, Lilly; Italiano Jr, Joseph E; Falet, Herve; Meiri, Karina F; Hartwig, John H;
The Neuronal Protein GAP-43 Associates with Microtubules and Lipid Rafts in Platelets and Megakaryocytes and Is Involved in Platelet Genesis Poster 53rd American Society of Hematology Meeting San Diego, USA - 9.12.2011. http://abstracts.hematologylibrary.org/cgi/content/abstract/118/21/2201?maxtoshow=&hits=10&RESULTFORMAT=&fulltext=begonja&searchid=1&FIRSTINDEX=0&volume=118&issue=21&resourcetype=HWCIT
19.
Jonsson, Terese; Begonja, Antonija Jurak; Kormann, Jan; Merkl, Barbara; Pluthero, Fred; Kahr, Walter H; Hartwig, John H; Plomann, Markus; Falet, Herve
The F-BAR Protein PACSIN 2 Specifically Coats the Anastomosing Intracellular Membrane Systems of Platelets and Megakaryocytes Poster 53rd American Society of Hematology Meeting San Diego, USA - 9.12.2011. http://abstracts.hematologylibrary.org/cgi/content/abstract/118/21/3261?maxtoshow=&hits=10&RESULTFORMAT=&fulltext=begonja&searchid=1&FIRSTINDEX=0&volume=118&issue=21&resourcetype=HWCIT
20.
Giannini S, Grozovsky R, Begonja AJ, Hoffmeister KM.
ß-1,4-Galactosyltransferase 1 Expression Is Required for Platelet Production in Vitro and In Vivo. Talk 53rd American Society of Hematology Meeting San Diego, USA - 9.12.2011. Blood 2011 vol. 118, issue 21, 2201.
21.
Giannini S, Grozovsky R, Begonja AJ, Hoffmeister KM.
. ß-1,4-Galactosyltransferase 1 Expression Is Required for Platelet Production in Vitro and In Vivo. Poster Annual Conference of the Society for Glycobiology Seattle, USA - 9.11.2011.
22.
Jönsson T, Begonja AJ, Hartwig JH, Falet H.
Expression and localization of the membrane-binding and -deforming protein, pacsin 2, in platelets and megakaryocytes. Poster International Society on Thrombosis and Haemostasis XXIII Congress Kyoto, Japan - 23.7.2011.
23.
Begonja AJ, Hoffmeister K, Hartwig JH, Falet H.
FlnA null megakaryocytes prematurely release large and fragile platelets that spontaneously microvesiculate and poorly circulate. Gordon Research Conference Galveston, TX, USA - 20.3.2011.
24.
Jönsson T, Begonja AJ, Hartwig JH, Falet H.
Expression and localization of the membrane-binding and -deforming protein, pacsin 2, in platelets and megakaryocytes. Poster Gordon Research Conference Galveston, TX, USA - 20.3.2011.
25.
Begonja, Antonija Jurak; Weber, Sarah E; Hoffmeister, Karin M; Hartwig, John H; Falet, Herve;
Filamin A Deficiency Leads to Premature Platelet Formation and Increased Clearance Poster 52nd American Society of Hematology Meeting Orlando, USA - 4.12.2010. http://abstracts.hematologylibrary.org/cgi/content/abstract/116/21/2027?maxtoshow=&hits=10&RESULTFORMAT=&fulltext=begonja&searchid=1&FIRSTINDEX=0&volume=116&issue=21&resourcetype=HWCIT
26.
Begonja AJ, Gambaryan S, Schulze H, Patel-Hett S, Italiano Jr. JE, Hartwig J, Walter U.
Differential Roles of cAMP and cGMP in Megakaryocyte Maturation and Platelet Formation. Poster International Society on Thrombosis and Haemostasis XXII Congress Boston, MA, USA - 11.7.2009.
27.
Hartwig JH, Begonja A, Falet H, Patel-Hett S, Thon J, Italiano J.
Megakaryocytes and Thrombopoiesis. Talk International Society on Thrombosis and Haemostasis XXII Congress Boston, MA, USA - 11.7.2009.
28.
Begonja AJ, Gambaryan S, Geiger J, Walter U.
Platelet NAD(P)H Oxidase-Mediated ROS Production Regulates alphaIIb beta3 Activation. Poster Gordon Research Conference Buellton, CA, USA - 5.3.2005.
29.
Antoljak, Nataša; Peran, Nena; Vrkić, Nada; Begonja, Antonija; Duvnjak, Marko; Topić, Elizabeta;
Endothelin (1-21) levels in various degrees of alcoholic liver cirrhosis - 1.1.2004.
30.
Begonja, Antonija; Topić, Elizabeta; Štefanović, Mario; Šimundić, Ana-Maria
Polimorfizam metilentetrahidrofolat reduktaze kao čimbenik rizika za rak glave i vrata( Methylenetetrahydrofolate reductase polymorphism and risk of head and neck cancer ) 4. hrvatski kongres medicinskih biokemičara Zagreb - 1.1.2003.
31.
Antoljak, Nataša; Vrkić, Nada; Begonja, Antonija; Nikolić-Heitzler, Vjeran; Bulj, Nikola
ENDOTELIN I ČINITELJ RASTA JETRE U BOLESNIKA S KORONARNOM BOLESTI SRCA( ENDOTHELIN AND HEPATOCYTE GROWTH FACTOR IN PATIENTS WITH CORONARY ARTERY DISEASE ) 4. hrvatski kongres medicinskih biokemičara Zagreb - 1.1.2003.
32.
Antoljak, Nataša; Peran, Nena; Vrkić, Nada; Begonja, Antonija; Topić, Elizabeta; Duvnjak, Marko
Razine endotelina (1-21) u različitim stupnjevima alkoholne ciroze jetre( Endothelin (1-21) levels in various degress of alcoholic liver cirrhossis ) Poster 4. hrvatski kongres medicinskih biokemičara Zagreb - 1.1.2003.
33.
Begonja, Antonija; Topić, Elizabeta; Šimundić, Ana-Maria; Štefanović, Mario; Nikolić, Vjeran
PAI-1 and fibrinogen polymorphisms in patients with myocardial infarction in Croatia Poster EUROMEDLAB 2003, IFCC Congress of Clinical Chemistry Barcelona - 1.1.2003.
34.
Štefanović, Mario; Topić, Elizabeta; Samardžija, Marina; Šimundić, Ana-Maria; Begonja, Antonija;
Cytochrome P450-CYP2C9 Genotyping in Warfarin Drug Therapy Optimization - 1.1.2003.
35.
Begonja, Antonija; Topić, Elizabeta; Štefanović, Mario; Šimundić, Ana-Maria;
MTHFR polymorphism in patients with head and neck cancer - 1.1.2003.
36.
Vrkić, Nada; Šimundić, Ana-Maria; Begonja, Antonija; Topić, Elizabeta; Nikolić Heitzler, Vjeran; Bulj, Nikola; Babić, Zdravko; Manola, Šime; Pintarić, Hrvoje; Žarković, Neven
Plasma Levels of Soluble Adhesion Molecules sICAM-1 in Atherosclerosis Related Diseases Poster 11th ALPE ADRIA CARDIOLOGY MEETING - 1.1.2003.
37.
Begonja, Antonija; Topić, Elizabeta; Šimundić, Ana-Maria; Štefanović, Mario
Polymorphisms of some coagulation factor genes in healthy Croatian subjects 13th Congress of the European Anthropological Association Zagreb - 1.1.2002.
38.
Begonja, Antonija; Topić, Elizabeta; Šimundić, Ana-Maria; Štefanović, Mario
Plasminogen activator inhibitor-1 genotype distribution in stroke patients Poster 7th Alps-Adria Congress Regensburg - 1.1.2002.
39.
Begonja, Antonija; Topić, Elizabeta; Šimundić, Ana-Maria; Štefanović, Mario
Plasminogen activator inhibitor-1 4G5G polymorphism in stroke patients Poster European Human Genetics Conference 2002 Strasbourg - 1.1.2002.
40.
Štefanović, Mario; Topić, Elizabeta; Samardžija, Marina; Begonja, Antonija
Genetic polymorphism of Cytochrome P450 CYP2D6 and CYP2C9 enzymes among Croatian population Poster 13th Congress of the European Anthropological Association Zagreb - 1.1.2002.
41.
Štefanovic, Mario; Begonja, Antonija; Topić, Elizabeta; Čurčić, Ivica; Šimundic, Ana-Maria
Cytochrome P450 - CYP2D6 polymorphism in head and neck cancer patients Poster European Human Genetics Conference 2002 Strasbourg - 1.1.2002.
42.
Vrkić, Nada; Mazul Sunko, Branka; Antoljak, Nataša; Krizmanić-Dekanić, Ankica; Begonja, Antonija; Tešija, Andrea; Topić, Elizabeta
ProANP (1-98), but not cystatin C has predictive value for occurance of acute renal insufficiency in critically ill septic patients Poster 7th Alps-Adria Congress Regensburg - 1.1.2002.
43.
Vrkić, Nada; Nikolić-Heitzler, Vjeran; Žarković, Neven; Begonja, Antonija; Topić, Elizabeta
Plasma levels of vasoactive peptides (proANP and BigET-1) and solubile adhesion molecules (sICAM-1) in patients with acute myocardial infarction (AMI) treated by percutaneous coronary intervention (PCI) Poster 18th International congress of clinical chemistry and laboratory medicine (ICCC) - 1.1.2002.
44.
Štefanović, Mario; Topić, Elizabeta; Samardžija, Marina; Begonja, Antonija;
Association of warfarin dosing with cytochrome P450-CYP2C9 genetic polymorphism - 1.1.2002.
45.
Vrkić, Nada; Nikolić-Heitzler, Vjeran; Begonja, Antonija; Antoljak, Nataša; Topić, Elizabeta;
Plasma levels of vasoactive propeptides (proANP and BigET-1) in patients with acute myocardial infarction treated by percutaneous coronary intervention - 1.1.2002.
46.
Begonja, Antonija; Topić, Elizabeta; Šimundić, Ana-Maria; Štefanović, Mario;
PCR-RFLP genotyping of two beta-fibrinogen gene polymorphisms - 1.1.2002.
47.
Štefanovic, Mario; Begonja, Antonija; Topić, Elizabeta; Čurčić, Ivica; Šimundić, Ana-Maria;
CYP2D6 polymorphism in patients with head and neck cancer - 1.1.2002.
48.
Begonja, Antonija; Topić, Elizabeta; Šimundić, Ana-Maria; Štefanović, Mario
Genetska varijacija faktora V, faktora II i inhibitora plazminogen aktivatora-1 u bolesnika s cerebrovaskularnim inzultom (Genetic variation of factor V, factor II and inhibitor of plasminogen activator-1 in stroke patients) Hrvatski kongres medicinskih biokemičara - 1.1.2001.
49.
Begonja, Antonija; Šimundić, Ana-Maria; Štefanović, Mario; Topić, Elizabeta;
A new genotyping method for PAI-1 4G/5G polymorphism - 1.1.2001.
50.
Šimundić, Ana-Maria; Štefanović, Mario; Begonja, Antonija; Topić, Elizabeta;
A new factor V Leiden PCR-SSCP detection method - 1.1.2001.
51.
Petrik, Jozsef; Koszegi, Tamas; Begonja, Antonija; Bilopavlović, Nada; Juretić, Dubravka; Kellermayer, Miklos; Čepelak, Ivana; Žanić Grubišić, Tihana; Pepeljnjak, Stjepan
Učinak okratoksina-A na apoptozu, nekrozu i razinu staničnog ATP-a u RK13 i LLC-PK1 bubrežnim stanicama( Effect of ochratoxin-A on apoptosis, necrosis and cellular ATP level in RK13 and LLC-PK1 renal cells ) Treći hrvatski kongres medicinskih biokemičara Zagreb - 1.1.1999.
52.
Topić, Elizabeta; Turek-Čubrilo, Mirjana; Begonja, Antonija; Šimundić, Ana-Maria; Demarin, Vida; Stančić, Vladimir; Žuntar, Irena
MTHFR polymorphism in patients with cerebrovascular insult and deep venous thrombosis
53.
Begonja AJ, Gambaryan S, Geiger J, Aktas B, Walter U.
NAD(P)H Oxidase Modulates GPIIbIIIa Activity In Platelets. Poster XIXth European Platelet Meeting Bad Brueckenau, Germany October 14-16, 2004
54.
Topić, Elizabeta; Štefanović, Mario; Begonja, Antonija; Žaja Franulović, Orjena; Jurčić, Zvonko;
Association of UDP Glucuronosyl Transferase Genetic Polymorphism with Gilbert Syndrome among Croatian Children
55.
Štefanović, Mario; Topić, Elizabeta; Samardžija, Marina; Begonja, Antonija;
Predicting the Warfarin Therapy Dose by Cytochrome P450-CYP2C9 Genotyping
56.
Topić, Elizabeta; Štefanović, Mario; Čulav, Jadranka; Samardžija, Marina; Blazinić, Franciska; Begonja, Antonija
Polymorphism of CYP2C9 and CYP2D6 in Predicting Drug Metabolism Phenotype

Znanstveni projekti

1. 1.9.2016. - 1.9.2020.
HRZZ doktorand ; voditelj, mentor; HRZZ; ;
2. 1.9.2016. - 1.8.2019.
HRZZ Uspostavni projekt; voditelj; HRZZ ; ;
3. 1.1.2016. - 31.12.2018.
ICGEB Research Grant - CRP Collaborative Research Programme - Early Career Return Grant; voditelj; UN; ;
4. 1.9.2014. - 31.8.2016.
The role of PI3P in thrombopoiesis; Voditelj projekta; NEWFELPRO Marie Curie-FP7-COFUND; ;
5. 1.1.2014. -
Uloga fosfatidilinozitida u nastanku trombocita; Voditelj projekta; Sveučilište u Rijeci; 48000.00 HRK;
6. 1.1.2011. - 1.1.2013.
Mechanisms of thrombocytopenia in WASP and WIP null mice; Član tima, post-doc; NIH RO1; ;
7. 1.1.2007. - 1.1.2011.
Filamin A-Syk interactions modulate platelet ITAM-based signaling; Član tima, post-doc; NIH RO1; ;
8. 1.1.2004. - 1.1.2007.
Cardiovascular cell-cell interactions; Član tima, doktorand; DFG/SFB 688; ;

Mentorstvo doktorandima

1. 1.4.2015. -
Ivana Bertović; Doktorat ; ; ;

Znanstveni skupovi

1. 3.3.2017. - 26.2.2017.
Gordon Research Conference “Cell Biology of Megakaryocytes and Platelets” Barga, Italy Invited Discussion Leader
2. 1.1.2015. -
Croatian Academy of Sceince and Arts Symposium: Developmental biology of platelets, thrombocitopenia, and myeloproliferative neoplasms. Rijeka, Croatia. Scientific board, member.

Recenzije

1. 2015. Thrombosis Research