Izv. prof. dr. sc. Hrvoje Jakovac dr.med.

Medicinski fakultet Katedra za fiziologiju, imunologiju i patofiziologiju

e-pošta : hrvoje.jakovac@medri.uniri.hr

MEĐUNARODNA VIDLJIVOST:
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ORCID
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Obrazovanje

1.1.2006. - 1.1.2007. E-learning tutor E-learning Tutoring E-learning akademija – ELA; CARNet
1.1.2004. - 1.1.2009. Doktor znanosti Poslijediplomski znanstveni studij Biomedicina Medicinski fakultet Sveučilišta u Rijeci
1.1.1996. - 1.1.2002. Doktor medicine Medicina Medicinski fakultet Sveučilišta u Rijeci

Radno iskustvo

1.1.2016. - Izvanredni profesor Zavod za fiziologiju i imunologiju, Medicinski fakultet Sveučilišta u Rijeci
1.1.2011. - 1.1.2016. Docent Zavod za fiziologiju i imunologiju, Medicinski fakultet Sveučilišta u Rijeci
1.1.2009. - 1.1.2011. Znanstveni novak - viši asistent Zavod za fiziologiju i imunologiju, Medicinski fakultet Sveučilišta u Rijeci
1.1.2003. - 1.1.2009. Znanstveni novak - asistent Zavod za fiziologiju i imunologiju, Medicinski fakultet Sveučilišta u Rijeci
1.1.2002. - 1.1.2003. Liječnik pripravnik Klinički bolnički centar Rijeka

Nagrade i priznanja

30.8.2018. Naslovnica časopisa Neuroscience - fotomikrografija iz članka Jakovac H et al. Expression Profiles of Metallothionein I/II and Megalin in Cuprizone Model of De- and Remyelination odabrana za naslovnicu (front cover) Neuroscience Volume 388.
23.9.2013. Priznanje za posebno značajan doprinos izgradnji i popularizaciji hrvatskog anatomskog i fiziološkog nazivlja
Uvršten u "Who is who" biografsku enciklopediju

Članstva

1.1.2014. - The European Association of Science Editors (EASE)
1.1.2003. - Hrvatsko imunološko društvo (HID)
1.1.2003. - Hrvatsko društvo fiziologa (HDF)
1.1.1999. - 1.1.2002. Studentska sekcija Hrvatskog liječničkog zbora
1.1.1999. - 1.1.2001. EMSA Hrvatska – European Medical Students' Association – Croatia

Nastavna djelatnost

Kolegiji

1.1.2011. - Fiziologija s patofiziologijom
Stručni studij Medicinsko laboratorijska dijagnostika
Medicinski fakultet Sveučilišta u Rijeci
voditelj
Norma sati:
1.1.2003. - Svi kolegiji svih studijskih smjerova koji se izvode na Katedri za fiziologiju, imunologiju i patofiziologiju Medicinskog fakulteta Sveučilišta u Rijeci


suradnik
Norma sati: puna norma

Mentor u završnim radovima

13.7.2012. - Izražaj i raspodjela metalotioneina u fetalnim tkivima miševa
Tina Rudančić
Stručni studij Medicinsko laboratorijske dijagnostike
Medicinski fakultet Sveučilišta u Rijeci
13.7.2012. - Izražaj metalotioneina i sadržaj cinka u spermijima bolesnika liječenih od neplodnosti
Majda Orešković
Stručni studij Medicinsko laboratorijske dijagnostike
Medicinski fakultet Sveučilišta u Rijeci
12.7.2012. - Izražaj i raspodjela metalotioneina u tkivima mladih i starih miševa
Milena Lemaić
Stručni studij Medicinsko laboratorijske dijagnostike
Medicinski fakultet Sveučilišta u Rijeci
12.7.2012. - Izražaj i raspodjela glikoproteina 96 u fetalnim tkivima miševa
Marina Dujmić
Stručni studij Medicinsko laboratorijske dijagnostike
Medicinski fakultet Sveučilišta u Rijeci

Gostujući nastavnik

1.1.2009. - Patofiziologija
Medicina
Medicinski fakultet Sveučilišta u Mostaru
suradnik
Norma sati: 90

Osobni razvoj

1.1.2006. - 1.1.2007. E-learning akademija (ELA) - E-learning Tutoring


Norma sati:

Izdavaštvo

1.4.2017. - 1.4.2017. Guyton and Hall Textbook of Medical Physiology

Financiranje: Medicinska naklada
1.1.2015. - Vodanović M. (urednik) i suradnici: Fiziološki priručnik sa hrvatsko-engleskim rječnikom

Financiranje: Naklada Slap
1.1.2013. - Kovač Z. (urednik) i suradnici: Klinička patofiziologija – etiopatogenetski čvorovi

Financiranje: Medicinska naklada, Zagreb
1.1.2011. - Kovač Z. (urednik) i suradnici: Patofiziologija - klinička nozologija i etiopatogenetski čvorovi

Financiranje: Sveučilište u Mostaru, Medicinski fakultet, Katedra za patofiziologiju
1.1.2010. - Kovač Z. (urednik) i suradnici: Klinička patofiziologija – Vježbe

Financiranje: Sveučilište u Zagrebu, Medicinski fakultet, Katedra za patofiziologiju
- Kovač Z. (urednik) i suradnici: Clinical pathophysiology – Etiopathogenetic clusters

Financiranje: Medicinska naklada, Zagreb

Znanstvena i umjetnička djelatnost

Znanstveni radovi

1. Grubić Kezele T, Fužinac-Smojver A, Ćurko-Cofek B, Jakovac H, Turković K.
Adultna neurogeneza – naglasak na subgranularnu i subventrikularnu zonu u sisavaca
Medicina Fluminensis 53 136 - 146 - 2017. http://hrcak.srce.hr/179749

Q3

2. Jakovac H, Grubić Kezele T, Šućurović S, Mulac-Jeričević B, Radošević-Stašić B.
Osteopontin–metallothionein I/II interactions in experimental autoimmunune encephalomyelitis
Neuroscience 350 133–145 - 2017. http://www.sciencedirect.com/science/article/pii/S0306452217301781

Q1

3. Grubic Kezele T, Blagojevic Zagorac G, Jakovac H, Domitrovic R, Radosevic-Stasic B.
Hippocampal expressions of metallothionein I/II and glycoprotein 96 in EAE-prone and EAE-resistant strains of rats.
Histol Histopathol. 2 137-151 - 2017.

Q1

4. Jakovac H, Ćuk M, Trobonjača Z, Mrakovčić-Šutić I, Radošević-Stašić B.
Thymic alterations induced by partial hepatectomy: Upregulation of glycoprotein 96, CD91 and TLR2 and generation of regulatory T cells.
Histology and histopathology 11597 - 2015.

Q1

5. Jakovac H, Grebić D, Mrakovcic-Šutić I, Rukavina D, Radošević-Stašić B.
Expression of metallothioneins in placental and fetal tissues in undisturbed and PGM-Zn treated syngeneic pregnancy
American Journal of BioScience. Special Issue: Oxidants-Antioxidants, The Biological Balance. 3 1-7 - 2015. http://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbio.s.2015030202.12.pdf

6. Grbas H, Jakovac H, Kovač D, Radoševi-Stašič B
Gallbladder Expression of Metallothionein I/II in Cholecystolithiasis. A Pilot Study
Annual Research & Review in Biology 6 278 - 2015. http://www.sciencedomain.org/abstract/7950

7. Ljubicic R, Jakovac H, Bistrović IL, Franceski T, Mufić AK, Karlović D.
Prevalence of metabolic syndrome among patients with major depressive disorder - differences between newly diagnosed first episode and recurrent disease.
Coll Antropol. 4 1065-9 - 2013.

8. Jakovac H.
Neuronal-astrocytic network of the mouse hippocampus
Glob Imaging Insights 3 1-1

9. Jakovac H, Grubić Kezele T, Radošević-Stašić B.
Expression Profiles of Metallothionein I/II and Megalin in Cuprizone Model of De- and Remyelination
Neuroscience 388 69-86

Q1

10. Grubić-Kezele, Tanja; Jakovac, Hrvoje; Tota, Marin; Čanadi-Jurešić, Gordana; Barac-Latas, Vesna; Milin Čedomila; Radošević-Stašić, Biserka
Metallothioneins I/II Expression in Rat Strains with Genetically Different Susceptibility to Experimental Autoimmune Encephalomyelitis
NEUROIMMUNOMODULATION (1021-7401) 20 (2013), 3; 152-163

11. Domitrović, Robert; Jakovac, Hrvoje; Vasiljev Marchesi, Vanja; Šain, Ivana; Romić, Željko; Rahelić, Dario
Preventive and therapeutic effects of oleuropein against carbon tetrachloride-induced liver damage in mice
Pharmacological research (1043-6618) 65 (2012), 4; 451-464

12. Domitrović, Robert; Jakovac, Hrvoje
Effects of standardized bilberry fruit extract (Mirtoselect®) on resolution of CCl4-induced liver fibrosis in mice
Food and chemical toxicology (0278-6915) 49 (2011), 4; 848-854

13. Jakovac, Hrvoje; Grebić, Damir; Tota, Marin; Barac-Latas, Vesna; Mrakovčić-Šutić, Ines; Milin, Čedomila; Radošević-Stašić, Biserka
Time-course expression of metallothioneins and tissue metals in chronic relapsing experimental autoimmune encephalomyelitis in DA rats
Histology and histopathology (0213-3911) 26 (2011), 2; 233-245

Q1

14. Domitrović, Robert; Jakovac, Hrvoje; Milin, Čedomila; Radošević-Stašić, Biserka
Dose- and time-dependent effects of luteolin on carbon tetrachloride-induced hepatotoxicity in mice
Experimental and Toxicologic Pathology (0940-2993) 61 (2009), 6; 581-589

15. Mićović, Vladimir; Bulog, Aleksandar; Kučić, Natalia; Jakovac, Hrvoje; Radošević-Stašić, Biserka
Metallothioneins and heat shock proteins in marine mussels as sensors of environmental pollution in Northern Adriatic Sea
Environmental Toxicology and Pharmacology (1382-6689) 28 (2009), 3; 439-447

16. Domitrović, Robert; Jakovac, Hrvoje; Grebić, Damir; Milin, Čedomila; Radošević-Stašić, Biserka
Dose- and time-dependent effects of luteolin on liver metallothioneins and metals in carbon tetrachloride-induced hepatotoxicity in mice
Biological Trace Elements Research (0163-4984) 126 (2008), 1-3; 176-185

17. Milin, Čedomila; Tota, Marin; Domitrović, Robert; Pantović, Radojka; Giacometti, Jasminka; Ćuk, Mira; Mrakovčić-Šutić, Ines; Jakovac, Hrvoje; Radošević-Stašić, Biserka.
Olive and corn-oil enriched diets as modulators of mineral content in submandibular gland during liver regeneration
Croatica chemica acta (0011-1643) 78 (2005), 3; 441-446

18. Tomić Linšak, Dijana; Linšak, Željko, Špirić, Zdravko; Srebočan, Emil; Glad, Marin; Cenov, Arijana; Jakovac, Hrvoje; Milin, Čedomila
Influence of cadmium on metallothionein expression and products of lipid peroxidation in the organs of hares (Lepus europaeus Pallas).
Journal of Applied Toxicology (1099-1263) (2013)

19. Jakovac, Hrvoje; Tota, Marin; Grebić, Damir; Grubić-Kezele, Tanja; Barac-Latas, Vesna; Mrakovčić-Šutić, Ines; Milin, Čedomila; Radošević-Stašić, Biserka.
Metallothionein I+II as an early sing of chronic relapsing experimental autoimmune encephalomyelitis in rats
Current Aging Science (1874-6098) 6 (2013), 1; 37-44

20. Grebić, Damir; Jakovac, Hrvoje; Mrakovčić-Šutić, Ines; Tomac, Jelena; Bulog, Aleksandar; Mićović, Vladimir; Radošević-Stašić, Biserka
Short-term exposure of mice to gasoline vapor increases the metallothionein expression in the brain, lungs and kidney
Histology and Histopathology (0213-3911) 22 (2007), 6; 593-601

Q1

21. Tota, Marin; Jakovac, Hrvoje; Špirić, Zdravko; Srebočan, Emil; Milin, Čedomila
Accumulated metals and metallothionein expression in organs of hares (Lepus europaeus Pallas) within natural gas fields of Podravina, Croatia
Archives of Environmental & Occupational Health (1933-8244) (2013)

22. Grebić, Damir; Tota, Marin; Jakovac, Hrvoje; Broznić, Dalibor; Marinić, Jelena; Čanadi, Gordana; Milin, Čedomila; Radošević-Stašić, Biserka
Metallothioneins and trace elements dyshomeostasis induced by exposure to gasoline vapor in mice
Histology and histopathology (0213-3911) (2013)

Q1

23. Domitrović, Robert; Jakovac, Hrvoje; Vasiljev Marchesi, Vanja; Blažeković, Biljana
Resolution of liver fibrosis by isoquinoline alkaloid berberine in CCl4-intoxicated mice is mediated by up-regulation of MMP-2 expression
Journal of medicinal food (1096-620X) 16 (2013), 6; 518-528

24. Domitrović, Robert; Jakovac, Hrvoje; Vasiljev Marchesi, Vanja; Vladimir-Knežević, Sanda; Cvijanović, Olga; Tadić, Žarko; Romić, Željko; Rahelić, Dario
Differential hepatoprotective mechanisms of rutin and quercetin in carbon tetrachloride-intoxicated BALB/cN mice
Acta pharmacologica Sinica (1671-4083) 33 (2012), 10; 1260-1270

25. Tota, Marin; Jakovac, Hrvoje; Grebić, Damir; Marinić, Jelena; Broznić, Dalibor; Čanadi-Jurešić, Gordana; Milin, Čedomila; Radošević-Stašić, Biserka
Kinetics of tissue iron in experimental autoimmune encephalomyelitis in rats
Biological trace element research (0163-4984) 143 (2011), 1; 332-343

26. Domitrović, Robert; Jakovac, Hrvoje; Romić, Željko; Rahelić, Dario; Tadić, Žarko
Antifibrotic activity of Taraxacum officinale root in carbon tetrachloride-induced liver damage in mice
Journal of ethnopharmacology (0378-8741) 130 (2010), 3; 569-577

27. Jakovac, Hrvoje; Grebić, Damir; Mrakovčić-Šutić, Ines; Tota, Marin; Broznić, Dalibor; Marinić, Jelena; Tomac, Jelena; Milin, Čedomila; Radošević-Stašić, Biserka
Metallothionein Expression and Tissue Metal Kinetics After Partial Hepatectomy in Mice
Biological Trace Element Research (0163-4984) 114 (2006), 1-3; 249-268

28. Milin, Čedomila; Marin, Tota; Domitrović, Robert; Giacometti, Jasminka; Pantović, Radojka; Ćuk, Mira; Mrakovčić-Šutić, Ines; Jakovac, Hrvoje; Radošević-Stašić, Biserka
Metal tissue kinetics in regenerating liver, thymus, spleen and submandibular gland after partial hepatectomy in mice
Biological trace element research (0163-4984) 108 (2005); 225-243

29. Radošević-Stašić, Biserka; Jakovac, Hrvoje; Grebić, Damir; Trobonjača, Zlatko; Mrakovčić-Šutić, Ines; Ćuk, Mira
Heat shock protein gp96 as potential regulator of morphostasis after partial hepatectomy in mice
Current Aging Science (1874-6128) 5 (2012), 3; 254-262

30. Domitrović, Robert; Jakovac, Hrvoje; Blagojević, Gordana
Hepatoprotective activity of berberine is mediated by inhibition of TNF-?, COX-2, and iNOS expression in CCl4-intoxicated mice
Toxicology (0300-483X) 280 (2011), 1/2; 33-43

Q1

31. Domitrović, Robert; Jakovac, Hrvoje; Tomac, Jelena; Šain, Ivana
Liver fibrosis in mice induced by carbon tetrachloride and its reversion by luteolin
Toxicology and applied pharmacology (0041-008X) 241 (2009), 3; 311-321

Q1

32. Grubić-Kezele, Tanja; Blagojević Zagorac, Gordana; Jakovac, Hrvoje; Domitrović, Robert; Milin, Čedomila; Radošević-Stašić, Biserka
Hepatic expression of metallothionein I/II, glycoprotein 96, IL-6, and TGF-beta in rat strains with different susceptibility to experimental autoimmune encephalomyelitis
Clinical & developmental immunology (1740-2522) (2013)

33. Jakovac, Hrvoje; Grebić, Damir; Barac-Latas, Vesna; Mrakovčić-Šutić, Ines; Radošević-Stašić, Biserka
Expression pattern of the endoplasmic reticulum stress protein gp96 in monophasic and chronic relapsing form of experimental autoimmune encephalomyelitis in rats
Histology and histopathology (0213-3911) 28 (2013), 1; 61-78

Q1

34. Domitrović, Robert; Jakovac, Hrvoje
Antifibrotic activity of anthocyanidin delphinidin in carbon tetrachloride-induced hepatotoxicity in mice
Toxicology (0300-483X) 272 (2010), 1/3; 1-10

Q1

35. Mrakovčić-Šutić, Ines; Jakovac, Hrvoje; Šimin, Marija; Grebić, Damir; Ćuk, Mira; Trobonjača, Zlatko; Radošević-Stašić, Biserka
Heat shock protein GP96 as an innate sensor of damage and activator of autorective NKT and regulatory T cells during liver regeneration
Histology Histopathology (0213-3911) 23 (2008), 9; 1111-1126

Q1

36. Jakovac, Hrvoje; Grebić, Damir; Grubić-Kezele, Tanja; Mrakovčić-Šutić, Ines; Rukavina, Daniel; Radošević-Stašić, Biserka.
Endoplasmic reticulum resident heat shock protein-gp96 as morphogenetic and immunoregulatory factor in syngeneic pregnancy
Histology and histopathology (0213-3911) 28 (2013), 10; 1285-1298

Q1

Znanstvene knjige

1.
Grebić, Damir; Jakovac, Hrvoje; Tota, Marin; Barac-Latas, Vesna; Milin, Čedomila; Mrakovčić-Šutić, Ines; Radošević-Stašić, Biserka
Hepatic metallothioneins and tissue metals in chronic relapsing form of experimental autoimmune encephalomyelitis in rats
2nd European Congress of Immunology / Reinhold E. Schmidt (ur.). - Bologna : Medimond Monduzzi Editore , 2009. 291-297 (ISBN: 978-88-7587-522-0).
2.
Jakovac, Hrvoje; Grebić, Damir; Mrakovčić-Šutić, Ines; Radošević-Stašić, Biserka
Stress protein gp96 as a regulator of fetal organogenesis
2nd European Congress of Immunology / Reinhold E. Schmidt (ur.). - Bologna : Medimond Monduzzi Editore , 2009. 231-235 (ISBN: 978-88-7587-522-0).
3.
Mrakovčić-Šutić, Ines; Grebić, Damir; Jakovac, Hrvoje; Radošević-Stašić, Biserka
Enhancing effects of gasoline and diesel vapor on intrahepatic natural killer T cells
8th International Congress of Neuroimmunology Free Papers ; Nagoya (Japan), October 15-19, 2006. / Takashi Tabira ; Takashi Yamamura and Junichi Kira (ur.). - Bologna, Italy : Monduzzi Editore S.p.A. - Medimond Inc., International Proceedings Division , 2006. 85-88 (ISBN: 978-88-7587-324-0).
4.
Jakovac, Hrvoje; Grebić, Damir; Mrakovčić-Šutić, Ines; Tomac, Jelena; Rukavina, Daniel; Radošević-Stašić, Biserka
Endoplasmic reticulum-resident heat shock protein gp96 as an innate sensor of damage induced by tissue remodelling, stress and bacterial peptidoglycan
8th International Congress of Neuroimmunology Free Papers ; Nagoya (Japan), October 15-19, 2006. / Takashi Tabira ; Takashi Yamamura and Junichi Kira (ur.). - Bologna, Italy : Monduzzi Editore-Medimond S.r.l. ; International Proceedings Division , 2006. 317-321 (ISBN: 978-88-7587-324-0).

Pozvana predavanja

1. Jakovac, Hrvoje; Grubić-Kezele, Tanja; Tota, Marin; Milin, Čedomila; Radošević-Stašić, Biserka
Metallothioneins expression and tissue metals kinetics during pathogenesis of chronic relapsing experimental autoimmune encephalomyelitis in rats.
Institute of Neuroanatomy, RWTH Aachen University, Germany - 28.6.2013.
2. Radošević-Stašić, Biserka; Jakovac, Hrvoje; Grebić, Damir; Grubić-Kezele, Tanja; Mrakovčić-Šutić, Ines; Barac-Latas, Vesna.
Morphogenetic and immunoregulatory roles of endoplasmic reticulum resident heat shock protein gp96
3. Mrakovčić-Šutić, Ines; Jakovac, Hrvoje; Grebić, Damir
The role of regulatory T cells (Tregs) in pregnancy
4. Jakovac, Hrvoje; Tota, Marin; Grebić, Damir; Grubić-Kezele, Tanja; Barac-Latas, Vesna; Mrakovčić-Šutić, Ines; Milin, Čedomila; Radošević-Stašić, Biserka
Metallothioneins I+II expression and tissue metals kinetics during chronic relapsing experimental autoimmune encephalomyelitis in rats

Kongresna priopćenja

1.
Jakovac H, Grubić Kezele T, Radošević- Stašić B.
Interaction of MT-I/II with megalin accelerates AKT-1 phosphorylation in cortical neurons and contributes to neurogenesis in cuprizone model of de- and remyelination. Annual Meeting of the Croatian Immunological Society, 2018 Zadar, Croatia - 20.10.2018.
2.
Jakovac H, Grubić Kezele T, Radošević- Stašić B.
MT-I/II interacts with megalin receptor providing survival signals via AKT-1 phosphorilation during cuprizone induced demyelination. The 12th Annual Symposium of the Croatian Physiological Society with international participation "Homeostasis - From Cell to Organ" Rijeka, Croatia - 29.9.2018.
3.
Grubić Kezele T, Šućurović S, Blagojević Zagorac G, Jakovac H, Mulac-Jeričević B, Radošević-Stašić B.
Hippocampal expression of heat shock protein GP 96, CD91 and TLR2 during experimental autoimmune encephalomyelitis in rats. The 12th Annual Symposium of the Croatian Physiological Society with international participation "Homeostasis - From Cell to Organ" Rijeka, Croatia - 28.9.2018.
4.
Hrvoje Jakovac, Tanja Grubić Kezele, Biserka Radošević-Stašić
Metallothionein I/II and megalin in cuprizone model of demyelination TRANSLATION OF BASIC IMMUNOLOGY AND NEUROSCIENCE TOOLS TO THERAPIES: Where Are We Now? Rijeka - 1.1.2016.
5.
Jakovac, Hrvoje; Grubić Kezele, Tanja; Tota, Marin; Radošević-Stašić, Biserka.
Metallothionein I/II and megalin expressions in cuprizone model of multiple scerosis. The 10th International Congress on Autoimmunity Leipzig, Germany - 1.1.2016.
6.
Grubić Kezele, Tanja; Blagojević Zagorac, Gordana; Jakovac, Hrvoje; Domitrović, Robert; Radošević-Stašić, Biserka.
Hippocampal expression of cytokines, metallothionein I/II and glycoprotein 96 in animal models of multiple sclerosis: Impact on adult neurogenesis. The 10th International Congress on Autoimmunity Leipzig, Germany - 1.1.2016.
7.
Jakovac H, Grubić Kezele T, Radošević-Stašić B.
Metallothionein I/II expression in cuprizone-induced demyelination. 5th Croatian Neuroscience Congress Split, - 1.1.2015.
8.
Jakovac, Hrvoje; Radošević-Stašić, Biserka
Upregulation of thymic expression of gp96, TGF-beta and induction of regulatory T cells by partial hepatectomy
9.
Radošević-Stašić, Biserka; Mrakovčić-Šutić, Ines; Jakovac, Hrvoje; Grebić, Damir; Tomac, Jelena; Rukavina, Daniel
Endoplasmic reticulum-resident heat shock protein gp96 as an innate sensor of damage induced by tissue remodelling, stress and bacterial peptidoglycan
10.
Jakovac, Hrvoje; Grubić-Kezele, Tanja; Mulac-Jeričević, Biserka; Tijanić, Tamara; Barac-Latas, Vesna; Radošević-Stašić, Biseka
Upregulation of osteopontin during the presymptomatic stage of chronic relapsing experimental autoimmune encephalomyelitis in rats
11.
Jakovac, Hrvoje; Marin, Tota; Grubić-Kezele, Tanja; Barac-Latas, Vesna; Mrakovčić-Šutić, Ines; Milin, Čedomila; Radošević-Stašić, Biserka
Upregulation of hepatic metallothioneins as early sign of developing chronic relapsing autoimmune encephalomyelitis in rats
12.
Marinić, Jelena; Tota, Marin; Čanadi Jurešić, Gordana; Broznić, Dalibor; Grebić, Damir; Jakovac, Hrvoje; Mrakovčić-Šutić, Ines; Radošević-Stašić, Biserka; Milin, Čedomila
Tissue metal content and metallothionein I + II protein expression in mouse brain, lungs and kidney after exposure to gasoline vapor
13.
Mrakovčić-Šutić, Ines; Jakovac, Hrvoje; Grebić, Damir; Tomac, Jelena; Radošević-Stašić, Biserka.
Peptidoglycan-Mediated Expression of Shock Protein gp96 and Metallothioneins
14.
Radošević-Stašić, Biserka; Mrakovčić-Šutić, Ines; Jakovac, Hrvoje; Grebić, Damir; Ćuk, Mira; Rukavina, Daniel
Morphogenetic and immunomodulatory functions of endoplasmic reticulum resident heat shock protein gp96
15.
Grubić-Kezele, Tanja; Jakovac, Hrvoje; Tota, Marin; Čanadi-Jurešić, Gordana; Barac-Latas, Vesna; Milin, Čedomila; Radošević-Stašić, Biserka
Metallothioneins I and II expression in rat strains with genetically different susceptibility to experimental autoimmune encephalomyelitis
16.
Jakovac, Hrvoje; Grubić-Kezele, Tanja; Mulac-Jeričević, Biserka; Tijanić, Tamara; Barac-Latas, Vesna; Radošević-Stašić, Biserka
Osteopontin as early marker of developing experimenal autoimmune encephalomyelitis in rats
17.
Grebić, Damir; Jakovac, Hrvoje; Tota, Marin; Barac-Latas, Vesna; Mrakovčić-Šutić, Ines; Milin, Čedomila; Radošević-Stašić, Biserka
Metallothioneins and tissue metals in chronic relapsing form of experimental autoimmune encephalomyelytis in rats
18.
Jakovac, Hrvoje; Mrakovčić-Šutić, Ines; Radošević-Stašić, Biserka
Glycoprotein 96 as a regulator of fetal organogenesis, embryonal implantation and compensatory liver growth
19.
Radošević-Stašić, Biserka; Jakovac, Hrvoje; Grebić, Damir; Mrakovčić-Šutić, Ines
Endoplasmic reticulum resident heat shock protein gp96 as regulator of normal and malignant growth
20.
Jakovac, Hrvoje; Grebić, Damir; Mrakovčić-Šutić, Ines; Rukavina, Daniel; Radošević-Stašić, Biserka
Enhanced expression of metallothioneins I/II in placenta and maternal liver, induced by syngeneic pregnancy and by peptidoglycan-monomer linked with zinc in mice
21.
Mrakovčić-Šutić, Ines; Jakovac, Hrvoje; Grebić, Damir; Radošević-Stašić, Biserka
Enhancing effects of syngeneic pregnancy and peptidoglycan-monomer linked with zinc on regulatory T cells in the maternal liver
22.
Radošević-Stašić, Biserka; Mrakovčić-Šutić, Ines; Jakovac, Hrvoje; Grebić, Damir; Tomac, Jelena; Rukavina, Daniel
Endoplasmic reticulum-resident heat shock protein gp96, natural killer T cells and regulatory T cells as regulators of self-tissue damages induced by various types of injuries
23.
Jakovac, Hrvoje; Grubić Kezele, Tanja; Valić, Maja; Valić, Zoran; Kukolja-Taradi, Sunčana; Vodanović, Marin
Balancing language imbalances in physiological terminology
24.
Milin, Čedomila; Tota, Marin; Grebić, Damir; Jakovac, Hrvoje; Broznić, Dalibor; Marinić, Jelena; Čanadi Jurešić, Gordana; Radošević-Stašić, Biserka
TRACE ELEMENTS DYSHOMEOSTASIS INDUCED BY EXPOSURE OF MICE TO GASOLINE VAPOR AND STRESS
25.
Orešković, Majda; Rudančić, Tina; Ljiljak, Dejan; Grubić Kezele, Tanja; Jakovac, Hrvoje
Metallothioneins expression and labile zinc content in spermatozoa of fertile males and subfertile patients with oligoasthenoteratozoospermia
26.
Domitrović, Robert; Jakovac, Hrvoje
Antifibrotic activity of anthocyanidin delphinidin in carbon tetrachloride-induced hepatotoxicity in mice
27.
Jakovac, Hrvoje; Grebić, Damir; Mrakovčić-Šutić, Ines; Radošević-Stašić, Biserka
Metallothioneins as regulators of liver regeneration and fetal organogenesis
28.
Grubić-Kezele, Tanja; Blagojević Zagorac, Gordana; Jakovac, Hrvoje; Domitrović, Robert; Radošević-Stašić, Biserka
Hepatic metallothioneins I+II, gp96, IL-6 and TGF-? as potential regulators of strain-dependent susceptibility to experimental autoimmune encephalomyelitis in rats
29.
Jakovac, Hrvoje; Tota, Marin; Grebić, Damir; Grubić-Kezele, Tanja; Barac-Latas, Vesna; Mrakovčić-Šutić, Ines; Milin, Čedomila; Radošević-Stašić, Biserka
Metallothioneins I+II expression and tissue metals kinetics during chronic relapsing experimental autoimmune encephalomyelitis in rats
30.
Radošević-Stašić, Biserka; Jakovac, Hrvoje; Grebić, Damir; Grubić-Kezele, Tanja; Mrakovčić-Šutić, Ines; Barac-Latas, Vesna.
Morphogenetic and immunoregulatory roleS of endoplasmic reticulum resident heat shock protein gp96
31.
Jakovac, Hrvoje; Mrakovčić-Šutić, Ines; Grebić, Damir; Radošević-Stašić, Biserka
Protective and immunoregulatory roles of metallothioneins expressed on fetoplacental unit and in maternal liver during pregnancy
32.
Grebić, Damir; Jakovac, Hrvoje; Tota, Marin; Barac-Latas, Vesna; Milin, Čedomila; Radošević-Stašić, Biserka
Expression of metallothioneins I+II and tissue metals in experimental chronic relapsing encephalomyelitis
33.
Ines Mrakovčić-Šutić, Hrvoje Jakovac, Damir Grebić, Aleksandar Bulog
Stres-prilagođenost naših odgovora izazovima nepredvidivog-privlačenje pozornosti medija na znastvene teme i istraživanja( Stress-the science of our flexible responses to an unpredictable world )
34.
Bulog, Aleksandar; Jakovac, Hrvoje; Grebić, Damir; Kučić, Natalia; Mrakovčić-Šutić, Ines; Radošević-Stašić, Biserka; Mićović, Vladimir
Metallothioneins and heat shock proteins in marine mussels as biomarkers of environmental pollution
35.
Grebić, Damir; Barac-Latas, Vesna; Jakovac, Hrvoje; Radošević-Stašić, Biserka
Metallothionein expression in rat brain during acute exprerimental autoimmune encephalomyelitis
36.
Grebić, Damir; Jakovac, Hrvoje; Mrakovčić-Šutić, Ines; Radošević-Stašić, Biserka
Heat shock protein 96 as a signal of stress and toxin-induced damages
37.
Mrakovčić-Šutić, Ines; Jakovac, Hrvoje; Grebić, Damir; Radošević-Stašić, Biserka
Regulatory T and NKT cells in syngeneic pregnancy
38.
Grebić, Damir; Jakovac, Hrvoje; Mrakovčić-Šutić, Ines; Tomac, Jelena; Bulog, Aleksandar; Mićović, Vladimir; Radošević-Stašić, Biserka
Chronic exposure to vapors of gasoline and diesel upregulates the metallothionein I and II expression in the olfactory brain of mice
39.
Grebić, Damir; Jakovac, Hrvoje; Mrakovčić-Šutić, Ines; Tomac, Jelena; Bulog, Aleksandar; Rukavina, Daniel; Radošević-Stašić, Biserka
Metallothioneins and heat shock protein gp96 as sensors of stress and toxin-induced damages
40.
Grebić, Damir; Mrakovčić-Šutić, Ines; Jakovac, Hrvoje; Radošević-Stašić, Biserka
Stress induced immunomodulation and upregulation of heat shock protein gp96
41.
Šain, Ivana; Jakovac, Hrvoje; Vasiljev Marchesi, Vanja; Vladimir-Knežević, Sanda; Cvijanović, Olga; Tadić, Žarko; Domitrović, Robert
Differential hepatoprotective mechanisms of rutin and quercetin in carbon tetrachloride-intoxicated BALB/cN mice
42.
Tota, Marin; Broznić, Dalibor; Grubić-Kezele, Tanja; Jakovac, Hrvoje; Barac-Latas, Vesna; Milin, Čedomila; Radošević-Stašić, Biserka
DISTRIBUTION OF TISSUE METALS IN THE BRAIN OF RAT STRAINS WITH GENETICALLY DIFFERENT SUSCEPTIBILITY TO EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
43.
Grubić-Kezele, Tanja; Jakovac, Hrvoje; Tota, Marin; Broznić, Dalibor; Barac-Latas, Vesna; Milin, Čedomila; Radošević-Stašić, Biserka
Distribution of labile zinc and metallothioneins I+II in preclical phase of chronic relapsing experimental autoimmune encephalomyelitis in rats
44.
Jakovac, Hrvoje; Grebić, Damir; Grubić-Kezele, Tanja; Barac-Latas, Vesna; Mrakovčić-Šutić, Ines; Radošević-Stašić, Biserka
Expression pattern of the endoplasmic reticulum stress protein gp96 during chronic relapsing experimental autoimmune encephalomyelitis in rats
45.
Tadić, Žarko; Šain, Ivana; Staver, Mihaela; Jakovac, Hrvoje; Domitrović, Robert
Terapijski učinak ekstrakta korijena maslačka (Taraxacum officinale Weber) u fibrozi jetre u miševa.( Therapeutic effect of dandelion (Taraxacum officinale Weber) root extract in liver fibrosis in mice )
46.
Tota, Marin; Jakovac Hrvoje; Grebić, Damir; Marinić, Jelena; Broznić, Dalibor; Čanadi Jurešić, Gordana; Milin, Čedomila; Radošević-Stašić, Biserka.
Kinetics of tissue iron in experimental autoimmune encephalomyelitis in rats
47.
Domitrović, Robert; Jakovac, Hrvoje; Radošević-Stašić, Biserka; Milin, Čedomila
Dose- and time-dependent effects of luteolin on heat shock protein gp96 expression in carbon tetrachloride-induced hepatotoxicity in mice
48.
Jakovac, Hrvoje; Grebić, Damir; Mrakovčić-Šutić, Ines; Tota, Marin; Broznić, Dalibor; Marinić, Jelena; Tomac, Jelena; Gobin, Ivana; Milin, Čedomila; Radošević-Stašić, Biserka
Metallothionein expression and tissue metal kinetics after partial hepatectomy in mice
49.
Jakovac, Hrvoje; Grebić, Damir; Mrakovčić-Šutić, Ines; Tota, Marin; Broznić, Dalibor; Marinić, Jelena; Tomac, Jelena; Milin, Čedomila; Radošević-Stašić, Biserka
Metallothionein and tissue metal kinetics after partial hepatectomy in liver, thymus and spleen
50.
Radošević-Stašić, Biserka; Mrakovčić-Šutić, Ines; Jakovac, Hrvoje, Grebić, Damir; Tomac, Jelena; Rukavina, Daniel
Peptidoglycan monomer as a modulator of gp96 expression during liver regeneration in mice
51.
Milin, Čedomila; Tota, Marin; Domitrović, Robert; Pantović, Radojka; Giacometti, Jasminka; Ćuk, Mira; Mrakovčić-Šutić, Ines; Jakovac, Hrvoje; Radošević-Stašić, Biserka
Olive and corn-oil enriched diets as modulators of tissue mineral content in the submandibular gland of partially hepatectomized mice
52.
Domitrović, Robert; Jakovac, Hrvoje; Tomac, Jelena; Šain, Ivana; Tadić, Žarko
Liver fibrosis in mice induced by carbon tetrachloride and its reversion by luteolin
53.
Domitrović, Robert; Jakovac, Hrvoje; Grebić, Damir; Milin, Čedomila; Radošević-Stašić, Biserka
Dose- and time-dependent effects of luteolin in carbon tetrachloride-induced hepatotoxicity in mice
54.
Radošević-Stašić, Biserka; Jakovac, Hrvoje; Mrakovčić-Šutić, Ines; Rukavina, Daniel
Endoplasmic reticulum resident heat shock protein Gp96 as morphogenetic and immunoregulatory factor in syngeneic pregnancy
55.
Grebić, Damir; Jakovac, Hrvoje; Stašić, Nikola; Pugel, Ester; Jonjić, Nives; Krašević, Maja; Mrakovčić-Šutić, Ines; Radošević-Stašić, Biserka
Altered expression of metallothioneins I/II and HLA-DR in uterine squamous lesions
56.
Mrakovčić-Šutić, Ines; Jakovac, Hrvoje; Grebić, Damir
Cross-talk between regulatory T and NKT cells during syngeneic pregnancy after treatment with peptidoglycan monomer linked with zinc
57.
Lemaić, Milena; Dujmić, Marina; Jakovac, Hrvoje; Grubić Kezele, Tanja; Radošević-Stašić, Biserka
Increased expression of metallothionein I+II in tissues of aged mice
58.
Bulog, Aleksandar; Jakovac, Hrvoje; Grebić, Damir; Mrakovčić-Šutić, Ines; Mićović, Vladimir; Radošević-Stašić, Biserka
Heat shock proteins and metallothionein expression in tissues of marine mussel Mytilus galloprovincialis as sensors of environmental pollution
59.
Jakovac, Hrvoje; Grebić, Damir; Krašević, Maja; Jonjić, Nives; Mrakovčić-Šutić, Ines; Radošević-Stašić, Biserka
Overexpression of glycoprotein 96 in uterine cervical intraepithelial lesions
60.
Mrakovčić-Šutić, Ines,; Jakovac, Hrvoje,; Grebić, Damir
The role of regulatory t cells (tregs) in pregnancy
61.
Šain, Ivana; Jakovac, Hrvoje; Vasiljev Marchesi, Vanja; Domitrović, Robert
Preventive and therapeutic effects of oleuropein against carbon tetrachloride-induced liver damage in mice
62.
Jakovac, Hrvoje; Mrakovčić-Šutić, Ines; Radošević-Stašić, Biserka
Modulation of thymic and hepatic heat shock protein gp96 expression by disturbance of morhostasis
63.
Jakovac, Hrvoje; Mrakovčić-Šutić, Ines; Grebić, Damir; Radošević-Stašić, Biserka
Hepatic and thymic overexpression of endoplasmic reticulum heat shock protein gp96 induced by stress and breakdown of morphostatis
64.
Jakovac, Hrvoje; Tota, Marin; Grebić, Damir; Marinić, Jelena; Broznić, Dalibor; Grubić Kezele, Tanja; Barac-Latas, Vesna; Milin, Čedomila; Radošević-Stašić, Biserka
Hepatic metallothioneins expression and tissue metals kinetics in chronic relapsing form of experimental autoimmune encephalomyelitis in rats
65.
Domitrović, Robert; Jakovac, Hrvoje; Grebić, Damir; Milin, Čedomila; Radošević-Stašić, Biserka
Dose- and time-dependent effects of luteolin on liver metallothioneins and metals in carbon tetrachloride-induced hepatotoxicity in mice
66.
Radošević-Stašić, Biserka; Jakovac, Hrvoje; Mrakovčić-Šutić, Ines; Grebić, Damir; Rukavina, Daniel.
Damage and stress-associated signals as inducers of endoplasmic reticulum resident heat shock protein gp96, natural killer T and regulatory T cells
67.
Jakovac, Hrvoje; Grebić, Damir; Mrakovčić-Šutić, Ines; Radošević-Stašić, Biserka
Metallothionein I/II distribution in maternal and fetal tissues during syngeneic pregnancy
68.
Jakovac, Hrvoje; Grebić, Damir; Tota, Marin; Canadi, Gordana; Broznić, Dalibor, Mrakovčić-Šutić, Ines; Marinić, Jelena; Tomac, Jelena; Milin, Čedomila; Radošević-Stašić, Biserka
Gasoline vapor induced alterations in metallothionein expression and tissue metal contents in mice
69.
Radošević-Stašić, Biserka; Mrakovčić-Šutić, Ines; Jakovac, Hrvoje; Grebić, Damir; Tomac, Jelena; Rukavina, Daniel
Endoplasmic reticulum-resident heat shock protein gp96 as an innate sensor of damage induced by tissue remodelling, stress and bacterial peptidoglycan

Znanstveni projekti

1. -
Fenotipska i funkcijska obilježja intrahepatičkog limfoidnog sustava; Suradnik; Ministarstvo znanosti, obrazovanja i športa Republike Hrvatske; ;
2. -
Morfogenetska svojstva stresnih proteina gp96 i metalotioneina; program Reparacijski i imunomodulacijski mehanizmi; Suradnik; Ministarstvo znanosti, obrazovanja i športa Republike Hrvatske; ; http://beta.bib.irb.hr/pregled/projekti/062-0621341-1337?report=1
3. -
Hrvatsko anatomsko i fiziološko nazivlje - HRANAFINA; Suradnik; Hrvatska zaklada za znanost; ;
4. -
Istraživanje uloge optineurina u neuroprotekciji ; Suradnik; Hrvatska zaklada za znanost ; ; http://www.hrzz.hr/default.aspx?id=78&pid=7459&rok=2013-11
5. -
Funkcije metalotioneina u demijelinizaciji uzrokovanoj kuprizonom; Voditelj; Sveučilište u Rijeci (UNIRI); ; https://portal.uniri.hr/Projekti/578?controler=projekti
6. -
Polimorfizmi gena za fosfolipaze A2, ciklooksigenazu-2 i peroksisomnim proliferatorom aktivirani receptor alfa i odgovor na antipsihotičnu terapiju u bolesnika s prvom psihotičnom epizodom; Suradnik; Sveučilište u Rijeci (UNIRI); ; https://portal.uniri.hr/Projekti/807?controler=projekti
7. -
Genetički i biokemijski biljezi metabolizma membranskih fosfolipida i masnih kiselina kao predskazatelji odgovora na antipsihotičnu terapiju u bolesnika s psihotičnom epizodom; Suradnik; Sveučilište u Rijeci (UNIRI); ; https://portal.uniri.hr/Projekti/1019?controler=projekti
8. -
Citoprotektivna i imunoregulacijska svojstva glikoproteina 96 i metalotioneina; Suradnik; Sveučilište u Rijeci (UNIRI); ; https://portal.uniri.hr/Projekti/222?controler=projekti

Mentorstvo doktorandima

1. 1.1.2015. -
Tanja Grubić Kezele; Doktorat Izražaj stresnih bjelancevina metalotioneina i glikoproteina 96 u štakorskih sojeva razlicite sklonosti za razvoj eksperimentalnog autoimunosnog encefalomijelitisa; Doktorski studij Biomedicina; 30. sijecnja 2015.;

Znanstveni skupovi

1. 13.4.2018. - 15.4.2018.
Četvrti hrvatsko-ruski psihijatrijski kongres Opatija, hrvatska Tajnik
2. 4.7.2016. -
TRANSLATION OF BASIC IMMUNOLOGY AND NEUROSCIENCE TOOLS TO THERAPIES: Where Are We Now? Rijeka Član organizacijskog odbora
3. 17.12.2015. -
MedRi Znanstveni piknik Rijeka Predsjednik Znanstvenog odbora
4. 1.1.2000. -
Croatian International Scientific Symposium for Medical Students and Young Doctors – CISS 2000 Rijeka, Croatia Član organizacijskog odbora
5. - 15.9.2013.
3rd Congress of Croatian Physiological Society and 1st Regional Congress of the Physiological Societes Rijeka, Croatia Član lokalnog organizacijskog odbora
6. - 3.3.2013.
Prvi hrvatsko – ruski kongres duhovne psihijatrije s međunarodnim sudjelovanjem Opatija, Croatia Tajnik
7. - 14.6.2007.
X International Congress of Reproductive Immunology Opatija, Hrvatska Član lokalnog organizacijskog odbora

Uredništva časopisa

1. 1.1.2014. - European Science Editing
http://www.ease.org.uk/resources/journal/journal-section-editors

Recenzije

1. 2014. Molecular Neurobiology Journal
2. 2014. Asian Journal of Neuroscience
3. 2014. Journal of Medicinal Food

Stručna djelatnost

Stručna aktivnost

1.
1.1.2003. - 1.1.2010.
Dijagnostika imunoloških bolesti
KBC Rijeka  

Javno djelovanje

Javna predavanja

1. 29.10.2013. - Detalji
Kukuljevićevi dani - simpozij Matice hrvatske
Varaždinske toplice

Popularizacija znanosti

1. 4.1.2018. - O biomedicini
Intervju u radio emisiji Zdravljak Hrvatskog radija, Radija Rijeka
Rijeka
2. 17.12.2015. - Detalji
MedRi Znanstveni piknik - studentski znanstveni simpozij
Rijeka
3. 1.1.2013. - Detalji
3rd Student Congress of Neuroscience - NeuRi 2013
Rijeka

Volonterstvo

1. - Volonter suradnik na projektu Hrvatsko anatomsko i fiziološko nazivlje - HRANAFINA
Rijeka, Zagreb
2. - Volonter na Zavodu za fiziologiju i imunologiju Medicinskog fakulteta Sveučilišta u Rijeci
Rijeka

Intervjui

1. 1.5.2017. - My life as an editor – Daniel Rukavina
European Science Editing 43(2) May 2017.

Novinski članci

1. 15.9.2013. - Detalji
Liječničke novine, broj 122
Zagreb
2. 1.1.2013. - Detalji
Speculum
Rijeka
3. 1.1.2013. - Detalji
Speculum
Rijeka

Medijski nastupi

1. 4.1.2018. - O biomedicini
Hrvatski radio, Radio Rijeka, emisija Zdravljak
Rijeka, Hrvatska